Christina Hvilsom
A5028400007- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Primate Behavior and Ecology
- Genetic and phenotypic traits in livestock
- Evolution and Genetic Dynamics
- Wildlife Ecology and Conservation
- Chromosomal and Genetic Variations
- Conservation, Biodiversity, and Resource Management
- Environmental DNA in Biodiversity Studies
- CRISPR and Genetic Engineering
- Species Distribution and Climate Change
- RNA and protein synthesis mechanisms
- Zoonotic diseases and public health
- Genetic Mapping and Diversity in Plants and Animals
- Bat Biology and Ecology Studies
- Genomic variations and chromosomal abnormalities
- Viral Infections and Outbreaks Research
- Genomics and Chromatin Dynamics
- Biochemical Analysis and Sensing Techniques
- T-cell and B-cell Immunology
- Animal Genetics and Reproduction
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Sperm and Testicular Function
- Environmental Conservation and Management
Research for Action
2025
International Union for Conservation of Nature (Bangladesh)
2022-2025
Copenhagen Zoo
2016-2025
University of Copenhagen
2012-2024
Fondazione Edmund Mach
2024
Japan Monkey Centre
2017
Japan Pediatric Society
2017
Springer Nature (Germany)
2017
High-coverage sequencing of 79 (wild and captive) individuals representing all six non-human great ape species has identified over 88 million single nucleotide polymorphisms providing insight into genetic variation evolutionary history enabling comparison with human diversity. In an effort to provide insights variation, the authors sequence wild- captive-born from across seven subspecies. Their data analyses shed light on population structure gene flow, inbreeding, inferred dynamics...
Genomes in the mist The mountain gorilla is an iconic species that at high risk of extinction. Xue et al. have sequenced 13 gorillas from two different populations to probe their genetic diversity. genomes show large tracts homozygosity and loss highly deleterious variants, indicating population bottlenecks inbreeding. This diversity appears started over 20,000 years ago may been caused by changes climate human-associated effects. Science , this issue p. 242
Phylogeny and characteristics of ruminants Ruminants are a diverse group mammals that includes families containing well-known taxa such as deer, cows, goats. However, their evolutionary relationships have been contentious, the origins distinctive digestive systems headgear, including antlers horns (see Perspective by Ker Yang). To understand among ruminants, L. Chen et al. sequenced 44 species representing 6 performed phylogenetic analysis. From this analysis, they were able to resolve...
Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born bonobos from 10 countries in Africa. found that chimpanzee population substructure makes genetic information good predictor geographic origin at country regional scales. Multiple lines evidence suggest gene flow occurred into ancestors central eastern between 200,000 550,000 years ago, probably with subsequent spread Nigeria-Cameroon...
DNA methylation is an epigenetic modification involved in regulatory processes such as cell differentiation during development, X-chromosome inactivation, genomic imprinting and susceptibility to complex disease. However, the dynamics of changes between humans their closest relatives are still poorly understood. We performed a comparative analysis CpG patterns 9 23 primate samples including all species great apes (chimpanzee, bonobo, gorilla orangutan) using Illumina Methylation450 bead...
Abstract Global conservation policy and action have largely neglected protecting monitoring genetic diversity—one of the three main pillars biodiversity. Genetic diversity (diversity within species) underlies species’ adaptation survival, ecosystem resilience, societal innovation. The low priority given to has been due knowledge gaps in key areas, including importance trends change; perceived high expense availability scattered nature data; complicated concepts information that are...
The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact genomic on fundamental biological processes. Analysis that insight into long-standing questions evolutionary conservation biology is urgent given severe threats these are facing. Here, we present high-coverage whole-genome data from 233 representing 86% genera all 16 families. This dataset was used, together with fossil calibration, create a nuclear DNA...
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding their clinical relevance remains largely incomplete. To systematically decipher the effects human variants, we obtained whole-genome data for 809 individuals from 233 primate species and identified 4.3 million common protein-altering variants with orthologs in humans. We show that these can be inferred to have nondeleterious humans based on presence at high allele...
Abstract Noncoding DNA is central to our understanding of human gene regulation and complex diseases 1,2 , measuring the evolutionary sequence constraint can establish functional relevance putative regulatory elements in genome 3–9 . Identifying genomic that have become constrained specifically primates has been hampered by faster evolution noncoding compared protein-coding 10 relatively short timescales separating primate species 11 previously limited availability whole-genome sequences 12...
Abstract Genetic monitoring of populations currently attracts interest in the context Convention on Biological Diversity but needs long-term planning and investments. However, genetic diversity has been largely neglected biodiversity monitoring, when addressed, it is treated separately, detached from other conservation issues, such as habitat alteration due to climate change. We report an accounting efforts monitor population Europe (genetic effort, GME), evaluation which can help guide...
Abstract Recent technological advances in the field of genomics offer conservation managers and practitioners new tools to explore for applications. Many these are well developed used by other life science fields, while others still development. Considering possibilities, choosing right tool(s) from toolbox is crucial can pose a challenging task. With this mind, we strive inspire, inform illuminate on how efforts benefit current genomic biotechnological revolution. inspirational case studies...
Abstract Genetic diversity is one of the three main levels biodiversity recognised in Convention on Biological Diversity (CBD). Fundamental for species adaptation to environmental change, genetic nonetheless under‐reported within global and national indicators. When it reported, focus often narrow confined domesticated or other commercial species. Several approaches have recently been developed address this shortfall reporting wild While multiplicity helpful any development process, can also...
Surveying genome-wide coding variation within and among species gives unprecedented power to study the genetics of adaptation, in particular proportion amino acid substitutions fixed by positive selection. Additionally, contrasting autosomes X chromosome holds information on dominance beneficial (adaptive) deleterious mutations. Here we capture sequence complete exomes 12 chimpanzees present largest set protein-coding polymorphism date. We report extensive adaptive evolution specifically...
Significance The X chromosome has a different inheritance pattern from the autosomes, direct interaction and potential conflict with Y chromosome, fewer copies than autosomes. Natural selection may, therefore, act differently on chromosome. We analyze polymorphism patterns in 10 great ape species using 87 high-coverage whole genomes. find that contains megabase-sized regions are almost without variation most species. No such found suggest independent very strong selective sweeps only...
Abstract Genetic diversity is essential for maintaining healthy populations and ecosystems. Several approaches have recently been developed to evaluate population genetic trends without necessarily collecting new data. Such “genetic indicators” enable rapid, large-scale evaluation across dozens thousands of species. Empirical studies, when available, provide detailed information that important management, such as estimates gene flow, inbreeding, erosion adaptation. In this article, we argue...
Abstract Homologous recombination rearranges genetic information during meiosis to generate new combinations of variants. Recombination also causes mutations, affects the GC content genome and reduces selective interference. Here, we use HiFi long-read sequencing directly detect crossover gene conversion events from switches between two haplotypes along single HiFi-reads testis tissue humans, chimpanzees gorillas as well human sperm samples. Furthermore, based on DNA methylation calls,...
We study genome-wide nucleotide diversity in three subspecies of extant chimpanzees using exome capture. After strict filtering, Single Nucleotide Polymorphisms and indels were called genotyped for greater than 50% exons at a mean coverage 35× per individual. Central (Pan troglodytes troglodytes) are the most polymorphic (nucleotide diversity, θw = 0.0023 site) followed by Eastern (P. t. schweinfurthii) (θw 0.0016) Western verus) 0.0008). A demographic scenario divergence without gene flow...
Major histocompatibility complex (MHC) class I genes are critically involved in the defense against intracellular pathogens. MHC diversity comparisons among samples of closely related taxa may reveal traces past or ongoing selective processes. The bonobo and chimpanzee closest living evolutionary relatives humans last shared a common ancestor some 1 mya. However, little is known concerning bonobos central chimpanzees, most numerous genetically diverse subspecies. Here, we used long-read...