Brenna M. Henn
A5002177095- Forensic and Genetic Research
- Genetic Associations and Epidemiology
- Genetic diversity and population structure
- Forensic Anthropology and Bioarchaeology Studies
- Race, Genetics, and Society
- Genetic Mapping and Diversity in Plants and Animals
- Pleistocene-Era Hominins and Archaeology
- Genetic and phenotypic traits in livestock
- Evolution and Genetic Dynamics
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Rangeland Management and Livestock Ecology
- RNA and protein synthesis mechanisms
- Genomics and Rare Diseases
- T-cell and B-cell Immunology
- Tuberculosis Research and Epidemiology
- Zoonotic diseases and public health
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Genomic variations and chromosomal abnormalities
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- melanin and skin pigmentation
- Yersinia bacterium, plague, ectoparasites research
- Chromosomal and Genetic Variations
- BRCA gene mutations in cancer
University of California, Davis
2017-2024
Stony Brook University
2013-2021
State University of New York
2015-2020
Boston University
2020
Texas A&M University
2020
University of California, Los Angeles
2020
Columbia University
2020
Stanford University
2003-2019
South African Medical Research Council
2016
Stellenbosch University
2016
High-throughput sequencing technology enables population-level surveys of human genomic variation. Here, we examine the joint allele frequency distributions across continental populations and present an approach for combining complementary aspects whole-genome, low-coverage data targeted high-coverage data. We apply this to generated by pilot phase Thousand Genomes Project, including whole-genome 2–4× coverage 179 samples from HapMap European, Asian, African panels as well target exons 800...
Africa is inferred to be the continent of origin for all modern human populations, but details prehistory and evolution in remain largely obscure owing complex histories hundreds distinct populations. We present data more than 580,000 SNPs several hunter-gatherer populations: Hadza Sandawe Tanzania, ≠Khomani Bushmen South Africa, including speakers nearly extinct N|u language. find that African populations today highly differentiated, encompassing major components variation are not found...
The Tyrolean Iceman, a 5,300-year-old Copper age individual, was discovered in 1991 on the Tisenjoch Pass Italian part of Ötztal Alps. Here we report complete genome sequence Iceman and show 100% concordance between previously reported mitochondrial consensus generated from our genomic data. We present indications for recent common ancestry present-day inhabitants Tyrrhenian Sea, that probably had brown eyes, belonged to blood group O lactose intolerant. His genetic predisposition shows an...
We challenge the view that our species, Homo sapiens, evolved within a single population and/or region of Africa. The chronology and physical diversity Pleistocene human fossils suggest morphologically varied populations pertaining to H. sapiens clade lived throughout Similarly, African archaeological record demonstrates polycentric origin persistence regionally distinct material culture in variety paleoecological settings. Genetic studies also indicate present-day structure Africa extends...
Genetic and paleoanthropological evidence is in accord that today’s human population the result of a great demic (demographic geographic) expansion began approximately 45,000 to 60,000 y ago Africa rapidly resulted occupation almost all Earth’s habitable regions. Genomic data from contemporary humans suggest this was accompanied by continuous loss genetic diversity, what called “serial founder effect.” In addition genomic data, serial effect model now supported genetics parasites,...
Duplications and deletions in the human genome can lead to variation copy number for genes genomic loci among humans. Such variants reveal evolutionary patterns have implications health. Sudmant et al. examined copy-number across 236 individual genomes from 125 populations. Deletions were under more selection, whereas duplications showed population-specific structure. Interestingly, Oceanic populations retain large postulated originated an ancient Denisovan lineage. Science , this issue...
North African populations are distinct from sub-Saharan Africans based on cultural, linguistic, and phenotypic attributes; however, the time extent of genetic divergence between north south Sahara remain poorly understood. Here, we interrogate multilayered history Africa by characterizing effect hypothesized migrations Near East, Europe, current diversity. We present dense, genome-wide SNP genotyping array data (730,000 sites) seven populations, spanning Egypt to Morocco, one Spanish...
Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships poorly understood. Here, we report data from 23 analysed at over half a million single-nucleotide polymorphisms, using genome-wide array designed for studying human history. The southern Khoisan fall into two groups, loosely corresponding northwestern southeastern Kalahari, which show separated within...
The Y chromosome and the mitochondrial genome have been used to estimate when common patrilineal matrilineal ancestors of humans lived. We sequenced genomes 69 males from nine populations, including two in which we find basal branches Y-chromosome tree. identify ancient phylogenetic structure within African haplogroups resolve a long-standing ambiguity deep Applying equivalent methodologies genome, time most recent ancestor (T(MRCA)) be 120 156 thousand years T(MRCA) 99 148 years. Our...
The Out-of-Africa (OOA) dispersal ∼ 50,000 y ago is characterized by a series of founder events as modern humans expanded into multiple continents. Population genetics theory predicts an increase mutational load in populations undergoing serial effects during range expansions. To test this hypothesis, we have sequenced full genomes and high-coverage exomes from seven geographically divergent human Namibia, Congo, Algeria, Pakistan, Cambodia, Siberia, Mexico. We find that individual vary...
The invention of agriculture is widely assumed to have driven recent human population growth. However, direct genetic evidence for growth after independent agricultural origins has been elusive. We estimated sizes through time from a set globally distributed whole mitochondrial genomes, separating lineages associated with populations those hunter-gatherers. coalescent-based analysis revealed strong distinct demographic expansions in Europe, southeastern Asia, and sub-Saharan Africa within...
Although a few hundred single nucleotide polymorphisms (SNPs) suffice to infer close familial relationships, high density genome-wide SNP data make possible the inference of more distant relationships such as 2(nd) 9(th) cousinships. In order characterize relationship between genetic similarity and degree kinship given timeframe 100-300 years, we analyzed sharing DNA inferred be identical by descent (IBD) in subset individuals from 23andMe customer database (n = 22,757) Human Genome...
Despite broad agreement that Homo sapiens originated in Africa, considerable uncertainty surrounds specific models of divergence and migration across the continent
Little is known about the history of click-speaking populations in Africa. Prior genetic studies revealed that Hadza eastern Africa are as distantly related to click speakers southern most other African populations. The Sandawe, who currently live within 150 km Hadza, only population whose language has been classified part Khoisan family. Linguists disagree on whether there any detectable relationship between and Sandawe languages. We characterized both mtDNA Y chromosome variation...
Human genetic diversity in southern Europe is higher than other regions of the continent. This difference has been attributed to postglacial expansions, demic diffusion agriculture from Near East, and gene flow Africa. Using SNP data 2,099 individuals 43 populations, we show that estimates recent shared ancestry between Africa are substantially increased when North Africans, rather Sub-Saharan considered. The gradient African accounts for previous observations low levels sharing with...
Although geneticists have extensively debated the mode by which agriculture diffused from Near East to Europe, they not directly examined similar agropastoral diffusions in Africa. It is unclear, for example, whether early instances of sheep, cows, pottery, and other traits pastoralist package were transmitted southern Africa demic or cultural diffusion. Here, we report a newly discovered Y-chromosome-specific polymorphism that defines haplogroup E3b1f-M293. This reveals monophyletic...
The human DARC (Duffy antigen receptor for chemokines) gene encodes a membrane-bound chemokine crucial the infection of red blood cells by Plasmodium vivax, major causative agent malaria. Of three allelic classes segregating in populations, FY*O allele has been shown to protect against P. vivax and is at near fixation sub-Saharan Africa, while FY*B FY*A are common Europe Asia, respectively. Due combination strong geographic differentiation association with malaria resistance, considered...