Shaila Musharoff
A5066486941- Genetic Associations and Epidemiology
- Computational and Text Analysis Methods
- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Asthma and respiratory diseases
- Forensic and Genetic Research
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Evolution and Genetic Dynamics
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Genetic and phenotypic traits in livestock
- Chromosomal and Genetic Variations
- HIV Research and Treatment
- Protein Tyrosine Phosphatases
- Global Maritime and Colonial Histories
- Gene expression and cancer classification
- CRISPR and Genetic Engineering
- IL-33, ST2, and ILC Pathways
- Socioeconomic Development in MENA
- Genomic variations and chromosomal abnormalities
- Sex and Gender in Healthcare
- Primate Behavior and Ecology
- Health and Conflict Studies
VA Palo Alto Health Care System
2021-2023
Stanford University
2012-2022
University of California, San Francisco
2018
Cornell University
2010
Hamad Medical Corporation
2010
Qatar University
2010
Weill Cornell Medical College in Qatar
2010
The Out-of-Africa (OOA) dispersal ∼ 50,000 y ago is characterized by a series of founder events as modern humans expanded into multiple continents. Population genetics theory predicts an increase mutational load in populations undergoing serial effects during range expansions. To test this hypothesis, we have sequenced full genomes and high-coverage exomes from seven geographically divergent human Namibia, Congo, Algeria, Pakistan, Cambodia, Siberia, Mexico. We find that individual vary...
Abstract The African Diaspora in the Western Hemisphere represents one of largest forced migrations history and had a profound impact on genetic diversity modern populations. To date, fine-scale population structure descendants remains largely uncharacterized. Here we present variation from deeply sequenced genomes 642 individuals North South American, Caribbean West populations, substantially increasing lexicon human genomic suggesting much to be discovered African-admixed populations...
Abstract Background Population structure among study subjects may confound genetic association studies, and lack of proper correction can lead to spurious findings. The Genotype-Tissue Expression (GTEx) project largely contains individuals European ancestry, but the v8 release also includes up 15% non-European ancestry. Assessing ancestry-based adjustments in GTEx improves portability this research across populations further characterizes impact population on GWAS colocalization. Results...
Abstract To characterize the extent and impact of ancestry-related biases in precision genomic medicine, we use 642 whole-genome sequences from Consortium on Asthma among African-ancestry Populations Americas (CAAPA) project to evaluate typical filters databases. We find significant correlations between estimated African ancestry proportions number variants per individual all variant classification sets but one. The source these is highlighted more detail by looking at interaction filtering...
To gain insights into evolutionary forces that have shaped the history of Bornean and Sumatran populations orang-utans, we compare patterns variation across more than 11 million single nucleotide polymorphisms found by previous mitochondrial autosomal genome sequencing 10 wild-caught orang-utans. Our analysis data yields a far ancient split time between two (∼3.4 years ago) estimates based on (0.4 ago), suggesting complex speciation process with moderate levels primarily male migration. We...
Abstract A primary goal of The C onsortium on sthma among frican-ancestry P opulations in the mericas (CAAPA) is to develop an ‘African Diaspora Power Chip’ (ADPC), a genotyping array consisting tagging SNPs, useful comprehensively identifying African specific genetic variation. This designed based novel variation identified 642 CAAPA samples ancestry with high coverage whole genome sequence data (~30× depth). extends pattern catalogued 1000 Genomes and Exome Sequencing Projects spectrum...
Abstract The Out-of-Africa (OOA) dispersal ~50,000 years ago is characterized by a series of founder events as modern humans expanded into multiple continents. Population genetics theory predicts an increase mutational load in populations undergoing serial effects during range expansions. To test this hypothesis, we have sequenced full genomes and high-coverage exomes from 7 geographically divergent human Namibia, Congo, Algeria, Pakistan, Cambodia, Siberia Mexico. We find that individual...
Sex-biased demographic events ("sex-bias") involve unequal numbers of females and males. These are typically inferred from the relative amount X-chromosomal to autosomal genetic variation have led conflicting conclusions about human history. Though population size changes alter diversity even in absence sex-bias, this has generally not been accounted for sex-bias estimators date. Here, we present a novel method identify sequence data that models estimates female fraction effective during...
Abstract Identifying the genetic and environmental factors underlying phenotypic differences between populations is fundamental to multiple research communities. To date, studies have focused on relationship population mean. Here we consider variance, i.e., “population variance structure.” In addition gene-gene gene-environment interaction, show that structure a direct consequence of natural selection. We develop ancestry double generalized linear model (ADGLM), statistical framework jointly...
Abstract Background Population structure among study subjects may confound genetic association studies, and lack of proper correction can lead to spurious findings. The Genotype-Tissue Expression (GTEx) project largely contains individuals European ancestry, but the final release (v8) also includes up 15% non-European ancestry. Assessing ancestry-based adjustments in GTEx provides an opportunity improve portability this research across populations further measure impact population on GWAS...
Abstract Despite the growing number of genome-wide association studies (GWAS), it remains unclear to what extent gene-by-gene and gene-by-environment interactions influence complex traits in humans. The magnitude genetic has been difficult quantify because GWAS are generally underpowered detect individual small effect. Here, we develop a method test for that aggregates information across all trait-associated loci. Specifically, whether SNPs regions European ancestry shared between American...
Background Understanding the contribution of rare and common genetic variants to disease susceptibility will probably require multiand transethnic sequencing studies that compare genomes many individuals with without a particular disease. Accounting for role population stratification at fine scales, both in terms genomic geographic location, be important because alleles are likely show more stratification. Here, we present results from sequencing, assembly analysis two Phase 3 HapMap. The...
People of the Qatari peninsula represent a relatively recent founding by small number families from three tribes Saudi peninsula, Persia, and Oman, with some African admixture. To assess combination this effect first-cousin marriages on Qatar's population genetic structure, in collaborative program Weill Cornell-Qatar Cornell-New York, Cornell University Qatar University, we assessed DNA samples self-reported nationals using Affymetrix SNP Array 5.0 to obtain genotype calls nearly...
Abstract BACKGROUND Asthma is a complex disease with striking disparities across racial and ethnic groups, which may be partly attributable to genetic factors. One of the main goals Consortium on among African-ancestry Populations in Americas (CAAPA) discover genes conferring risk asthma populations African descent. METHODS We performed genome-wide meta-analysis 11 CAAPA datasets (4,827 cases 5,397 controls), genotyped Diaspora Power Chip (ADPC) including existing GWAS array data. The...