A5088984046- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Parathyroid Disorders and Treatments
- Epigenetics and DNA Methylation
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Kruppel-like factors research
- Autophagy in Disease and Therapy
- Influenza Virus Research Studies
- Nuclear Receptors and Signaling
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Dermatological and Skeletal Disorders
- Sulfur Compounds in Biology
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Protein Tyrosine Phosphatases
- Circular RNAs in diseases
- Aortic Thrombus and Embolism
Massachusetts General Hospital
2020-2023
Harvard University
2020-2023
Creighton University
2018-2022
Nanjing Normal University
2022
Jiangxi Provincial Children's Hospital
2020
Cardiovascular Research Center
2020
Western University of Health Sciences
2020
CHI Health Creighton University Medical Center - Bergan Mercy
2019
Army Medical University
2013
Daping Hospital
2013
Risk stratification of COVID-19 patients upon hospital admission is key for their successful treatment and efficient utilization resources. We sought to evaluate the risk factors on (including comorbidities, vital signs, initial laboratory assessment) associated with ventilation need in-hospital mortality in COVID-19.We established a retrospective cohort from Mass General Brigham hospitals. Demographic, clinical, data were obtained electronic medical records admitted laboratory-confirmed...
Risk stratification of COVID-19 patients upon hospital admission is key for their successful treatment and efficient utilization resources. To evaluate the risk factors associated with ventilation need mortality. We established a retrospective cohort from Mass General Brigham hospitals. Demographic, clinical, laboratory data were obtained electronic medical records admitted to laboratory-confirmed before May 19th, 2020. Using Massachusetts Hospital (MGH, derivation cohort), multivariable...
Emerging evidence suggests that males are more susceptible to severe infection by the SARS-CoV-2 virus than females. A variety of mechanisms may underlie observed gender-related disparities including differences in sex hormones. However, precise which female hormones provide protection against infectivity remains unknown. Here we report new insights into molecular basis interactions between spike (S) protein and human ACE2 receptor. We further glycosylation receptor enhances infectivity....
Vascular restenosis often presents as a consequence of injury to the vessel wall, resulting from stenting and other interventional procedures. Such arteries induces proliferation Smooth Muscle Cells (VSMCs), in cellular hyperplasia restenosis. We others have previously reported de-novo production different cytokines growth factors such Tumor Necrosis Factor Alpha (TNF-α) Insulin like Growth 1 (IGF-1), after vascular injury. As complex it is, profuse VSMCs appears be occurring due several...
Increased expression of DNA methyltransferase-1 (DNMT1) associates with the progression many human diseases. Because DNMT1 induces cell proliferation, drugs that inhibit have been used to treat proliferative these are nonspecific inhibitors DNMT1, subsidiary events or compensatory mechanisms activated in absence limit their therapeutic application. Here, we studied molecular occur during angioplasty-induced restenosis and found inhibition both vitro vivo approaches resulted induction...
Vascular calcification is a hallmark of atherosclerotic disease and serves as strong predictor risk factor for cardiovascular events. Growing evidence suggests that autophagy may play protective role in early atherosclerosis. The precise effects on VSMC-mediated remain unknown. In this study, we utilized multi-omic profiling to investigate impaired at the transcriptional level key driver VSMC calcification. Our findings revealed an essential determinant We observed osteogenic environment...
Emerging evidence suggests that males are more susceptible to severe infection by the SARS-CoV-2 virus than females. A variety of mechanisms may underlie observed gender-related disparities including differences in sex hormones. However, precise which female hormones provide protection against infectivity remains unknown. Here we report new insights into molecular basis interactions between spike (S) protein and human ACE2 receptor. We further glycosylation receptor enhances infectivity....
Emerging evidence suggests that males are more susceptible to severe infection by the SARS-CoV-2 virus than females. A variety of mechanisms may underlie observed gender-related disparities including differences in sex hormones. However, precise which female hormones provide protection against infectivity remains unknown. Here we report new insights into molecular basis interactions between spike (S) protein and human ACE2 receptor. We further glycosylation receptor enhances infectivity....
Objective: To explore the application value of mass spectrometry (MS) combined with next generation sequencing (NGS) in diagnosing neonatal inherited metabolic diseases (IMD). Methods: The clinical information, metabolites blood and urine, gene results 19 neonates IMD coming from Department Neonatology Jiangxi Provincial Children's Hospital March 2017 to September 2019 were analyzed retrospectively. detected by liquid chromatography tandem urine gas chromatography-mass...
Abstract The RNA‐dependent RNA polymerase (RdRp) of influenza virus, consisting subunits PA, PB1, and PB2 proteins, is responsible for viral mRNA transcription vRNA replication. Cap‐dependent endonuclease (CEN) exists in PA subunit RdRp mediates the critical “cap‐snatching” step transcription, which considered as a promising anti‐influenza target. In this manuscript, series novel compounds were designed, synthesized, biologically investigated CEN inhibitors. cellular activities target...
Introduction: Calciphylaxis is a rare, understudied disease of accelerated vascular calcification affecting the skin and soft tissue leading to painful wounds, amputations, reduced survival. The underlying mechanisms calciphylaxis remain incompletely understood. Objective: In this study, we aimed identify altered signaling pathways novel differentially expressed genes (DEGs) associated with characterize protein expression top DEGs in vasculature. Methods: 6 case 3 control tissues were...
Objective To study in vitro the effects of low-intensity pulsed ultrasound (LIPUS) on proliferation and differentiation cultured myoblasts,and to explore cellular molecular mechanisms behind any therapeutic effect LIPUS.Methods Myoblasts were isolated from skeletal muscles mice vitro.Treatment control groups proliferating differentiating myoblasts defined.The treatment exposed LIPUS at 1.5 MHz a spatial temporal average intensity 30 mW/cm2,for 20 min daily,the group for 6 consecutive days 4...