Haakon H. Sigurslid
A5021920040- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Electrochemical Analysis and Applications
- Hemoglobinopathies and Related Disorders
- Analytical Chemistry and Sensors
- COVID-19 and healthcare impacts
- Electrochemical sensors and biosensors
- Aortic Disease and Treatment Approaches
- Iron Metabolism and Disorders
- Aortic aneurysm repair treatments
- Cardiovascular Health and Disease Prevention
- Vitamin K Research Studies
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- PARP inhibition in cancer therapy
- SARS-CoV-2 and COVID-19 Research
- Biomarkers in Disease Mechanisms
- Sepsis Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Genetic factors in colorectal cancer
- Parathyroid Disorders and Treatments
- Pulmonary Hypertension Research and Treatments
- Connective tissue disorders research
- Genetic Associations and Epidemiology
Harvard University
2018-2023
Massachusetts General Hospital
2018-2023
Harvard University Press
2018
Risk stratification of COVID-19 patients upon hospital admission is key for their successful treatment and efficient utilization resources. We sought to evaluate the risk factors on (including comorbidities, vital signs, initial laboratory assessment) associated with ventilation need in-hospital mortality in COVID-19.We established a retrospective cohort from Mass General Brigham hospitals. Demographic, clinical, data were obtained electronic medical records admitted laboratory-confirmed...
Potentiometric sensing of ions with ion-selective electrodes (ISEs) is a powerful technique for selective and sensitive measurement in complex matrices. The application ISEs generally limited to laboratory settings, because most commercially available reference are large, delicate, expensive, not suitable point-of-use or point-of-care measurements. This work utilizes cotton thread as substrate fabrication robust miniaturized that applications. Thread-based Cl-, K+, Na+, Ca2+ were developed....
Objective— Inflammatory stimuli enhance the progression of atherosclerotic disease. Inflammation also increases expression hepcidin, a hormonal regulator iron homeostasis, which decreases intestinal absorption, reduces serum levels and traps within macrophages. The role macrophage in development atherosclerosis remains incompletely understood. objective this study was to investigate effects hepcidin deficiency decreased on atherosclerosis. Approach Results— Hepcidin- LDL (low-density...
Risk stratification of COVID-19 patients upon hospital admission is key for their successful treatment and efficient utilization resources. To evaluate the risk factors associated with ventilation need mortality. We established a retrospective cohort from Mass General Brigham hospitals. Demographic, clinical, laboratory data were obtained electronic medical records admitted to laboratory-confirmed before May 19th, 2020. Using Massachusetts Hospital (MGH, derivation cohort), multivariable...
Abstract Data from clinical studies suggests a strong association between underlying cardiometabolic disease and worse outcomes in COVID-19. Given that the SARS-CoV-2 virus has unique marked affinity to human angiotensin-converting enzyme 2 (ACE2) receptor, one potential explanation behind this phenomenon may involve higher expression of ACE2 receptor these patients. Here, we analyzed polymorphisms locus COVID-19 severity 62 patients found be positive by polymerase chain reaction. Of...
Objective: Arterial stiffness is a risk factor for cardiovascular disease, including heart failure with preserved ejection fraction (HFpEF). MGP (matrix Gla protein) implicated in vascular calcification animal models, and circulating levels of the uncarboxylated, inactive form (ucMGP) are associated disease-related all-cause mortality human studies. However, role arterial uncertain. Approach Results: We examined association ucMGP calcification, carotid-femoral pulse wave velocity (PWV),...
Abstract Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute hepatic fibrosis, but role BMP development NAFLD unclear. In this study, treatment with either two inhibitors reduced triglyceride content diabetic ( db/db ) mice. inhibitor-induced decrease levels was associated decreased mRNA encoding Dgat2, an enzyme integral synthesis. Treatment hepatoma cells BMP2 induced DGAT2 expression...
Introduction: Pulmonary artery (PA) hemodynamics are important predictors of mortality. However, genetic mechanisms underlying increased PA stiffness in diseases such as pulmonary hypertension poorly understood, and targeted therapies limited. Evaluation frequently requires invasive right heart catheterization, limiting large-scale studies. This study leveraged cardiac magnetic resonance (CMR) imaging to non-invasively determine characterize pulsatility, an established measure vascular...