A5100764280- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Cardiovascular Issues in Pregnancy
- Genomics and Rare Diseases
- Birth, Development, and Health
- Hepatitis C virus research
- Genetic Associations and Epidemiology
- Natural product bioactivities and synthesis
- Cardiovascular Disease and Adiposity
- Ectopic Pregnancy Diagnosis and Management
- Hormonal Regulation and Hypertension
- Antiplatelet Therapy and Cardiovascular Diseases
- Medicinal Plant Pharmacodynamics Research
- Alzheimer's disease research and treatments
- Balance, Gait, and Falls Prevention
- Parkinson's Disease Mechanisms and Treatments
- Cancer Risks and Factors
- Cardiovascular and exercise physiology
- Cardiovascular Health and Risk Factors
- Acute Ischemic Stroke Management
- Gout, Hyperuricemia, Uric Acid
- Cerebral Palsy and Movement Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Muscle and Compartmental Disorders
Boston University
2021-2025
Beth Israel Deaconess Medical Center
2022-2024
Arbor Research Collaborative for Health
2022-2024
Tianjin University of Traditional Chinese Medicine
2023-2024
Framingham Heart Study
2024
National Heart Lung and Blood Institute
2024
Jinzhou Central Hospital
2022-2023
Hadassah Medical Center
2023
Harvard University
2023
Xiangya Hospital Central South University
2023
Infected bone defects (IBDs) remains a challenging problem for orthopedists. Clinically, routine management IBDs has two stages: debridement and systematic antibiotics administration to control infection, secondary grafting repair defects. Whereas the efficacy is not satisfactory, because overuse of may lead systemic toxicity, emergence drug-resistant bacteria, as well surgery would cause additional trauma economic burden patients. Therefore, it imperative develop novel scaffold one-stage...
The pulmonary artery pulsatility index (PAPi), calculated from the ratio of pulse pressure to right atrial pressure, is a predictor ventricular failure after inferior myocardial infarction and left assist device implantation. Whether PAPi associated with adverse outcomes across heterogeneous population unknown.We examined consecutive patients undergoing heart catheterization between 2005 2016 in hospital-based cohort. Multivariable Cox models were utilized examine association all-cause...
To evaluate the value of serial C-reactive protein (CRP) measurements in predicting risk cardiovascular disease (CVD), cancer, and mortality. The analysis was performed using data from two prospective, population-based observational cohorts: Prevention Renal Vascular End-Stage Disease (PREVEND) study Framingham Heart Study (FHS). A total 9253 participants had CRP available at examinations (PREVEND: 1997-1998 2001-2002; FHS Offspring cohort: 1995-1998 1998-2001). All were natural...
Obesity and adiposity are associated with an increased risk of heart failure preserved ejection fraction (HFpEF); yet, specific underlying mechanisms remain unclear. We sought to examine the association obesity-related biomarkers including adipokines (leptin, resistin, adiponectin), inflammatory markers (CRP [C-reactive protein], IL-6 [interleukin-6]), insulin resistance (HOMA-IR) HFpEF status, exercise capacity, cardiovascular outcomes.
Abstract INTRODUCTION Alzheimer's disease (AD) is a common disorder of the elderly that both highly heritable and genetically heterogeneous. METHODS We investigated association AD with variants aggregates rare coding non‐coding in 13,371 individuals diverse ancestry whole genome sequencing (WGS) data. RESULTS Pooled‐population analyses all identified genetic at apolipoprotein E ( APOE ) BIN1 associated p < 5 × 10 −8 ). Subgroup‐specific haplotype on chromosome 14 including PSEN1...
Obesity and cardiometabolic dysfunction have been associated with cancer risk severity. Underlying mechanisms remain unclear.The aim of this study was to examine associations obesity related traits incident cancer.FHS (Framingham Heart Study) PREVEND (Prevention Renal Vascular End-Stage Disease) participants without prevalent were studied, examining obesity, body mass index (BMI), waist circumference, visceral adipose tissue (VAT) subcutaneous depots, C-reactive protein (CRP) future in Cox...
Abstract Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine association upstream mediators as ascertained by fatty-acid derived eicosanoid and eicosanoid-related metabolites HFpEF status exercise manifestations HFpEF. Among 510 participants chronic dyspnea LVEF who underwent invasive cardiopulmonary testing, find that 70 890 related are associated status, including 17 named 53 putative eicosanoids (FDR q...
BackgroundPrior studies examined variants within presenilin-2 (PSEN2), presenilin-1 (PSEN1), and amyloid precursor protein (APP) genes. However, previously-reported clinically-relevant other predicted damaging missense (DM) have not been characterized in a newer release of the Alzheimer's Disease Sequencing Project (ADSP).ObjectiveTo characterize DM PSEN2, PSEN1, APP participants from ADSP.MethodsWe identified rare (MAF < 1%) 14,641 individuals with whole genome sequencing 16,849 exome...
Background Premature and early menopause are independently associated with greater risk of cardiovascular disease (CVD). However, mechanisms linking age CVD remain poorly characterized. Methods Results We measured 71 circulating protein biomarkers in 1565 postmenopausal women enrolled the FHS (Framingham Heart Study). examined association tested whether modified incident outcomes (heart failure, major CVD, all-cause death) using multivariable-adjusted linear regression Cox models,...
Heart failure with preserved ejection fraction (HFpEF) and heart reduced (HFrEF) are distinct clinical entities, yet there is scant evidence for associations of proteomic signatures future development HFpEF versus HFrEF.
Background A parental history of cardiovascular disease (CVD) confers greater risk future CVD among offspring. Whether the presence modifiable factors contribute to or modify in offspring is unclear. Methods and Results We studied 6278 parent-child trios multigenerational longitudinal Framingham Heart Study. assessed (smoking, hypertension, diabetes, obesity, hyperlipidemia). Multivariable Cox models were used evaluate association Among individuals (mean age 45±11 years), 44% had at least 1...
Alzheimer's Disease (AD) is a common disorder of the elderly that both highly heritable and genetically heterogeneous. Here, we investigated association between AD variants aggregates rare coding noncoding in 13,371 individuals diverse ancestry with whole genome sequence (WGS) data. Pooled-population analyses identified genetic or near APOE, BIN1, LINC00320 significantly associated (p < 5×10-8). Population-specific haplotype on chromosome 14 including PSEN1 Hispanics, further supported by...
Objective: Arterial stiffness is a risk factor for cardiovascular disease, including heart failure with preserved ejection fraction (HFpEF). MGP (matrix Gla protein) implicated in vascular calcification animal models, and circulating levels of the uncarboxylated, inactive form (ucMGP) are associated disease-related all-cause mortality human studies. However, role arterial uncertain. Approach Results: We examined association ucMGP calcification, carotid-femoral pulse wave velocity (PWV),...
OBJECTIVE: To investigate published cases of cervical ectopic pregnancy between 2000 and 2018 compare management strategies treatment success rates based on initial patient characteristics. METHODS: PubMed, EMBASE, Web Science were searched to capture peer-reviewed citations 2018. Cases reporting either β-hCG level, crown–rump length, or gestational sac diameter for each individual included. Data regarding the article information, characteristics, used, outcomes collected. Initial was...
Cancer and heart failure (HF) are the leading causes of death in Western world. Shared mechanisms such as fibrosis may underlie either disease entity, furthermore it is unknown whether this relationship sex-specific.We sought to investigate how fibrosis-related biomarker galectin-3 (gal-3) aids identifying individuals at risk for new-onset cancer HF, differs between sexes.Gal-3 was measured baseline 4-year follow-up 5,786 patients PREVEND (Prevention Renal Vascular Endstage Disease) study....
To investigate the classification performance of support vector machine in mild traumatic brain injury (mTBI) from normal controls.Twenty-four mTBI patients (15 males and 9 females; mean age, 38.88 ± 13.33 years) 24 age sex-matched controls (13 11 40.46 11.4 underwent resting-state functional MRI examination. Seven imaging parameters, including amplitude low-frequency fluctuation (ALFF), fractional (fALFF), regional homogeneity (ReHo), degree centrality (DC), voxel-mirrored homotopic...
Yang-ge dancing is a culturally specific exercise in which people are required to perform motor skills coordination with rhythmic music. As an integrated both physical (decelerating the progression of aged-related function degeneration) and mental benefits, it has gained great popularity China, especially among middle-aged older adults. It remains largely unknown whether (YG) can effectively improve main symptoms Parkinson's disease (PD), while conventional rehabilitation program been...
Prior studies using the ADSP data examined variants within presenilin-2 (PSEN2), presenilin-1 (PSEN1), and amyloid precursor protein (APP) genes. However, previously-reported clinically-relevant other predicted damaging missense (DM) have not been characterized in a newer release of Alzheimer's Disease Sequencing Project (ADSP).
This study aims to create an all-around insight into the evolutions, status, and global trends of rhythmic auditory stimulation (RAS) research via enhanced bibliometric methods for 2001–2020 time period. Articles concerning RAS were extracted from Web Science database. CiteSpace, Bibliometrix, VOSviewer, Graphpad Prism employed analyze publication patterns trends. A total 586 publications related between 2001 2020 retrieved The researcher Goswami U. made greatest contribution this field....