The aim was to study factors contributing torsade de pointes in the acquired long QT syndrome.Anaesthetised rabbits or cats were given a continuous infusion of methoxamine and class III agent almokalant (at rate 5 25 nmol.kg-1.min-1, respectively) effects on incidence dispersion examined. Effects action potentials recorded from Purkinje fibres ventricular cells also studied."High rate" prolonged QTc interval [from 162(SEM 6.2) ms 211 (5.3) ms, p < 0.001] initiated 9/10 after dose 391(116.3)...

Human mesenchymal stem cells (hMSCs) and three-dimensional (3D) woven poly(ɛ-caprolactone) (PCL) scaffolds are promising tools for skeletal tissue engineering. We hypothesized that in vitro culture duration medium additives can individually interactively influence the structure, composition, mechanical, molecular properties of engineered tissues based on hMSCs 3D poly(ɛ-caprolactone). Bone marrow were suspended collagen gel, seeded scaffolds, cultured 1, 21, or 45 days under chondrogenic...

Potentiometric sensing of ions with ion-selective electrodes (ISEs) is a powerful technique for selective and sensitive measurement in complex matrices. The application ISEs generally limited to laboratory settings, because most commercially available reference are large, delicate, expensive, not suitable point-of-use or point-of-care measurements. This work utilizes cotton thread as substrate fabrication robust miniaturized that applications. Thread-based Cl-, K+, Na+, Ca2+ were developed....

Near-infrared (NIR) spectroscopy is a useful technique for quantitative measurements of intact tablets, but it suffers from limitations due to the fact that changes in physical properties sample strongly affect recorded spectrum. In this work, time-resolved transmission NIR was utilized conduct tablets. The enables separation absorption scattering and can therefore handle parameters samples better way than conventional spectroscopy. experiments were conducted using pulsed Ti:sapphire laser...

Magneto-Archimedes levitation (MagLev) enables the separation of powdered mixtures illicit drugs (cocaine, methamphetamine, heroin, fentanyl, and its analogues), adulterants, diluents based on density, allows presumptive identification individual components. Small samples (mass <50 mg), with low concentrations drugs, present a particular challenge to analysis for forensic chemists. The MagLev device, cuvette containing solution paramagnetic gadolinium(III) chelate in non-polar solvent,...

Time-resolved spectroscopy in the visible and near-infrared (NIR) regions was used a feasibility study for analysis of solid pharmaceuticals. The objective experiments to interaction light with pharmaceutical solids investigate usefulness method as an analytical tool spectroscopic analysis. In these experiments, pulsed Ti:sapphire laser white generation water utilized form source visible/NIR region. focused onto surface tablets, transmitted detected by time-resolving streak camera. Two types...

The aim was to test the hypothesis that recently reported embryotoxic effect of class III antiarrhythmic agents may be a result electrophysiological disturbances induced by these agents.Comparative studies drug effects in adult and fetal rat were performed using three experimental models: (1) almokalant upon pregnancy mortality rats given daily doses 0, 10, 50, 100, or 400 mumol.kg-1 orally diet on days 6-15 pregnancy; (2) d-sotalol (1-1000 microM), (0.1-100 microM) dofetilide (0.01-10...

We report a novel system for time-resolved diffuse remission spectral measurements, based on short light continuum pulses generated in an index-guided crystal fiber, and spectrometer-equipped streak camera. The enables recordings of absorption reduced scattering coefficients turbid media the wavelength range 500 - 1200 nm with resolution 5 temporal 30 ps. optical properties are calculated by fitting solution diffusion equation to time-dispersion curve at each wavelength. Example measurements...

Pneumatically operated soft robots require complex infrastructure for their operation: microcontrollers must control hard pneumatic valves via power electronics. Although digital logic gates based on have been demonstrated as a replacement electronic control, the development of memory from is cumbersome (three with mono-stable membranes single S-R latch), and such only capable holding, but not storing, information; after reset, relax to idle states, information lost. In this work, we...

The control of pneumatically driven soft robots typically requires electronics. Microcontrollers are connected to power electronics that switch valves and pumps on off. As a recent alternative, fluidic methods have been introduced, in which digital logic gates permit multiple actuation states be achieved systems. Such systems demonstrated autonomous behaviors without the use However, controllers required complex fabrication processes. To democratize exploration controllers, we developed...

Highly charged microcapsules have been prepared using the internal phase separation technique. The charges are introduced by ionic dispersants, which characterized with respect to surface activity a quartz crystal microbalance dissipation monitoring and optical tensiometry. long-term stability of microcapsule suspension without excess dispersant, as well at high strength, investigated. Three types dispersants evaluated: weak polyacid (poly(methacrylic acid)), small set amphiphilic block...

The scope of this work is a new methodology to correct conventional near-infrared (NIR) data for scattering effects. technique aims at measuring the absorption coefficient samples rather than total attenuation measured in NIR spectroscopy. main advantage that independent path length light inside sample and therefore method based on time-resolved spectroscopy modeling transport by diffusion theory. This provides an measure properties light. yields clear over other preprocessing techniques,...

While the density is a central property of polymer film, it can be difficult to measure in films with thickness ∼100 nm or less, where structure interfaces and confinement chains may perturb packing dynamics polymers relative bulk. This Article demonstrates use magneto-Archimedes levitation (MagLev) estimate thin hydrophobic ranging from ∼10 1000 by employing substrate water-soluble sacrificial release layer delaminate films. We validate performance MagLev for this application ∼1 μm range...

Time-resolved spectroscopy is a powerful technique permitting the separation of scattering properties from chemical absorption sample. The reduced coefficient and are usually obtained by fitting diffusion or Monte Carlo models to measured data using numerical optimization techniques. However, these methods do not take spectral dimension into account during evaluation procedure, but evaluate each wavelength separately. A procedure involving multivariate may seem more appealing for people used...

By use of time-resolved spectroscopy it is possible to separate light scattering effects from chemical absorption in samples. In the study propagation short pulses turbid samples reduced coefficient and are usually obtained by fitting diffusion or Monte Carlo models measured data numerical optimization techniques. this we propose a prediction model with semiparametric modeling technique: least-squares support vector machines. The main advantage technique that uses theoretical time dispersion...

Here we study diffusion and flow through a new hydrogel formed from colloidal silica nontronite clay that was made anisotropic by magnetic alignment of the microstructure.

Abstract Magneto‐Archimedes levitation (MagLev) enables the separation of powdered mixtures illicit drugs (cocaine, methamphetamine, heroin, fentanyl, and its analogues), adulterants, diluents based on density, allows presumptive identification individual components. Small samples (mass &lt;50 mg), with low concentrations drugs, present a particular challenge to analysis for forensic chemists. The MagLev device, cuvette containing solution paramagnetic gadolinium(III) chelate in non‐polar...

Summary Studies on colloidal aggregation have brought forth theories stability of gels and models for dynamics. Still, a complete link between developed frameworks obtained laboratory observations has to be found. In this work, aggregates silica nanoparticles (20 nm) are studied using diffusion limited cluster (DLCA) reaction (RLCA) models. These processes driven by the probability particles aggregate upon collision. This is one in DLCA close zero RLCA process. We show how study from static...

Summary In this study, we investigate the functional behaviour of intensity in high‐angle annular dark field scanning transmission electron micrograph images. The model material is a silica particle (20 nm) gel at 5 wt%. By assuming that response monotonically increasing with mass thickness silica, an estimate form calculated using maximum likelihood approach. We conclude linear provides fair but power function significantly better for estimating amount z ‐direction. work adds to development...