A5046112080- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Electrolyte and hormonal disorders
- Chronic Kidney Disease and Diabetes
- Folate and B Vitamins Research
- Acute Kidney Injury Research
- Bone health and treatments
- Muscle and Compartmental Disorders
- Vitamin D Research Studies
- Potassium and Related Disorders
- Hemoglobinopathies and Related Disorders
- Pharmacological Effects and Toxicity Studies
- Bone and Joint Diseases
- Iron Metabolism and Disorders
- Vitamin K Research Studies
- Neurological and metabolic disorders
- Systemic Sclerosis and Related Diseases
- Bone health and osteoporosis research
- Oral and gingival health research
- Thyroid and Parathyroid Surgery
- Medical Imaging and Pathology Studies
- Hypertrophic osteoarthropathy and related conditions
- Renal Diseases and Glomerulopathies
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
Massachusetts General Hospital
2016-2025
Harvard University
2015-2024
Mass General Brigham
2023-2024
Universitätsklinikum Aachen
2018
Cedars-Sinai Medical Center
2018
RWTH Aachen University
2018
Pathways Behavioral Services
2018
RELX Group (United States)
2018
Brigham and Women's Hospital
2011-2015
Pediatric Nephrology of Alabama
2013
Severe hyponatremia (<120 mEq/L) in hospitalized patients has a high mortality rate. We hypothesized that underlying diseases causing attribute to rather than itself.The relationship between and serum sodium (sNa) was examined 45,693 admitted single community teaching hospital January 1996 December 2007. conducted comprehensive retrospective review of the medical records 53 who died after developing sNa <120 mEq/L before or admission 32 survived <110 mEq/L.Mortality rates tended increase as...
Calcific uremic arteriolopathy (CUA) is an often fatal condition with no effective treatment. Multiple case reports and series have described intravenous sodium thiosulfate (STS) administration in CUA, but studies systematically evaluated this treatment.This study included 172 patients undergoing maintenance hemodialysis who had CUA were treated STS between August 2006 June 2009 at Fresenius Medical Care North America. Of these, 85% completed therapy. Clinical, laboratory, mortality data...
Accurate identification of risk factors for calcific uremic arteriolopathy (CUA) is necessary to develop preventive strategies this morbid disease. We investigated whether baseline recorded at hemodialysis initiation would identify patients future CUA in a matched case-control study using data from large dialysis organization. Hemodialysis with newly diagnosed ( n =1030) between January 1, 2010, and December 31, 2014, were by age, sex, race 1:2 ratio without =2060). Mean ages controls 54 55...
Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification. The ability MGP to inhibit calcification requires the activity vitamin K–dependent enzyme, which mediates carboxylation. We investigated how carboxylation influences risk calciphylaxis in adult patients receiving dialysis and examined effects K deficiency on Our study included 20 hemodialysis with (cases) without (controls) matched for age, sex, race, warfarin use. Cases had higher plasma levels uncarboxylated (ucMGP)...
Calciphylaxis is a potentially fatal disorder of abnormal calcium deposition. Patients commonly present with painful retiform to stellate purpuric lesions that often undergo ulceration and necrosis, increasing the risk infection life-threatening sepsis. Treatment multifaceted, improved outcomes have been demonstrated intravenous sodium thiosulfate; however, use this medication can be limited by its adverse effects. The topical thiosulfate has successfully reported for superficial deposits in...
The association between gut dysbiosis, high intestinal permeability, and endotoxemia-mediated inflammation is well established in CKD. However, changes the circulating microbiome patients with CKD have not been studied. In this pilot study, we compare blood profile healthy controls using 16S ribosomal DNA sequencing.Blood bacterial was studied buffy coat samples quantitatively by PCR qualitatively targeted metagenomic sequencing a molecular pipeline specifically optimized for cross-sectional...
Urinary neutrophil gelatinase-associated lipocalin (NGAL) has shown promise in differentiating acute tubular necrosis (ATN) from other types of kidney injuries (AKIs) cirrhosis, particularly hepatorenal syndrome (HRS). However, NGAL is not currently available clinical practice North America.Urinary was measured a prospective cohort 213 US hospitalized patients with decompensated cirrhosis (161 AKI and 52 reference without AKI). assessed for its ability to discriminate ATN non-ATN predict...
BackgroundIn clinical practice, sodium correction rates are frequently limited in patients with severe hyponatremia to prevent neurologic complications. The implications of on overall mortality and length hospital stay unclear.MethodsIn this multicenter observational study, we evaluated the association mortality, stay, central pontine myelinolysis (CPM) hospitalized (admission serum level less than 120 mEq/l).ResultsThe cohort included 3274 patients. A rate 6 mEq/l/24 hours was observed 38%,...
Background and objectives Vitamin D (25-hydroxyvitamin D; 25[OH]D) deficiency is common in patients initiating long-term hemodialysis, but the safety efficacy of nutritional vitamin supplementation this population remain uncertain. Design, setting, participants, & measurements This randomized, placebo-controlled, parallel-group multicenter trial compared two doses ergocalciferol with placebo between October 2009 March 2013. Hemodialysis (n=105) 25(OH)D levels ≤32 ng/ml from 32 centers...