A5038639745- Dialysis and Renal Disease Management
- Pregnancy and preeclampsia studies
- Vitamin D Research Studies
- Pharmacological Effects and Toxicity Studies
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Gestational Diabetes Research and Management
- Erythropoietin and Anemia Treatment
- Birth, Development, and Health
- Acute Kidney Injury Research
- Heart Failure Treatment and Management
- Kidney Stones and Urolithiasis Treatments
- Iron Metabolism and Disorders
- Pregnancy and Medication Impact
- Bone health and osteoporosis research
- Prenatal Substance Exposure Effects
- Vitamin C and Antioxidants Research
- Bipolar Disorder and Treatment
- Pancreatitis Pathology and Treatment
- Viral gastroenteritis research and epidemiology
- Hemodynamic Monitoring and Therapy
- Lysosomal Storage Disorders Research
- Ureteral procedures and complications
- Hemoglobinopathies and Related Disorders
- Folate and B Vitamins Research
Massachusetts General Hospital
2008-2018
Harvard University
2007-2016
Boston University
2014
University of Pennsylvania
2008
Abstract Studies examining the relationship between total circulating 25-hydroxyvitamin D [25(OH)D] levels and bone mineral density (BMD) have yielded mixed results. Vitamin D–binding protein (DBP), major carrier for 25(OH)D, may alter biologic activity of vitamin D. We hypothesized that free bioavailable calculated from DBP, serum albumin levels, would be more strongly associated with BMD than 25(OH)D. measured in 49 healthy young adults enrolled Metabolic Abnormalities College-Aged...
African Americans have a markedly higher incidence of ESRD compared with other racial groups. Two variants in the APOL1 gene, to date observed only among individuals recent ancestry, associate increased risk for renal disease Americans. Here, we investigated whether these alleles also age at initiation chronic hemodialysis. We performed cross-sectional study 407 nondiabetic who participated Accelerated Mortality on Renal Replacement (ArMORR) study, prospective cohort incident hemodialysis...
Background and objectives Vitamin D (25-hydroxyvitamin D; 25[OH]D) deficiency is common in patients initiating long-term hemodialysis, but the safety efficacy of nutritional vitamin supplementation this population remain uncertain. Design, setting, participants, & measurements This randomized, placebo-controlled, parallel-group multicenter trial compared two doses ergocalciferol with placebo between October 2009 March 2013. Hemodialysis (n=105) 25(OH)D levels ≤32 ng/ml from 32 centers...
The effect of clinically recovered AKI (r-AKI) on future pregnancy outcomes is unknown. We retrospectively studied all women who delivered infants between 1998 and 2007 at Massachusetts General Hospital to assess whether a previous episode r-AKI associated with subsequent adverse maternal fetal outcomes, including preeclampsia. was defined as rise in serum creatinine concentration 1.5-fold above baseline. compared without history CKD (eGFR>90 ml/min per 1.73 m
Patients with end-stage renal disease (ESRD) suffer exceptionally high mortality rates in their first year of chronic hemodialysis. Both vitamin D and fibroblast growth factor (FGF)-23 levels correlate survival these patients. Klotho is a protein the D/FGF-23 signaling pathway that has been linked accelerated aging early animal models. We therefore hypothesized genetic variation gene might be associated subjects ESRD. tested association between 12 single nucleotide polymorphisms (SNPs)...
An episode of clinically recovered acute kidney injury (r-AKI) has been identified as a risk factor for future hypertension and cardiovascular disease. Our objective was to assess whether r-AKI associated with preeclampsia other adverse pregnancy outcomes identify severity AKI or time interval between complications. We conducted retrospective cohort study women who delivered infants 1998 2016 at Massachusetts General Hospital. defined using the 2012 Kidney Disease Improving Global Outcomes...
The mechanisms underlying erythropoietin resistance are not fully understood. Carbamylation is a post-translational protein modification that can alter the function of proteins, such as erythropoietin. hypothesis this study carbamylation burden independently associated with resistance.In nonconcurrent prospective cohort incident hemodialysis patients in United States, carbamylated albumin, surrogate overall burden, 158 individuals at day 90 dialysis initiation and index (defined average...
Abstract Introduction The optimal use of erythropoiesis stimulating agents (ESAs) to treat anemia in end stage renal disease remains controversial due reported associations with adverse events. In analyzing these associations, studies often utilize ESA resistance indices (ERIs), characterize a patient's response ESA. this study, we examine whether ERI is an adequate measure resistance. Methods We used retrospective data from nonconcurrent cohort study incident hemodialysis patients the...
Evidence exists that variability in hemoglobin may be an independent risk factor for mortality among hemodialysis patients. These observations were based on a 1996 cohort, time when anemia management differed greatly from present. Design, settings, participants and measurements: A retrospective cohort study of patients incident to Fresenius Medical Care units between 2004 2005 (n = 6644). Hemoglobin (Hgb-Var) was defined each subject as the residual SD linear regression model hemoglobin.The...
Introduction The relationship between gestational diabetes mellitus (GDM) and postpregnancy mental health disorders has been inconsistently reported. Additionally, race/ethnicity data are limited. We sought to elucidate the intersection of these relationships. Methods analyzed 18,109 women aged 18–40 with self-reported race/ethnicity. Women (n = 659) without 14,461) GDM were followed for a median 4.4 (interquartile range 1.4–6.8) 4.0 (1.5–6.4) years, respectively, incident disorders....
Background and objectives Carbamylation describes a post–translational protein modification associated with adverse outcomes in ESRD, but the risk implications of changes carbamylation over time are not well understood. Design, setting, participants, & measurements We investigated 1-year natural history patients initiating maintenance hemodialysis determined prognostic value longitudinal relation to mortality. In nested patient-control study, we measured serial carbamylated albumin...
Background and objectives Kidney stones are associated with future development of hypertension, diabetes, the metabolic syndrome. Our objective was to assess whether stone formation before pregnancy hypertensive complications in pregnancy. We hypothesized that is a marker disease would be higher risk for maternal Design, setting, participants, & measurements conducted retrospective cohort study women who delivered infants at Massachusetts General Hospital from 2006 2015. Women abdominal...