A5090762842- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Diabetes Management and Research
- Diabetes and associated disorders
- Vitamin D Research Studies
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Breastfeeding Practices and Influences
- Diabetes Treatment and Management
- Maternal and fetal healthcare
- Prenatal Substance Exposure Effects
- Pregnancy and Medication Impact
- Cardiovascular Issues in Pregnancy
- Infant Nutrition and Health
- Bone health and osteoporosis research
- Neonatal Respiratory Health Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diversity and Career in Medicine
- Genetic Syndromes and Imprinting
- Genetic Associations and Epidemiology
- Diabetes Management and Education
- Prenatal Screening and Diagnostics
- Innovations in Medical Education
Broad Institute
2020-2025
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Brigham and Women's Hospital
2010-2024
Harvard Pilgrim Health Care
2023
Brown University
2023
University of South Florida
2023
Maine Farmland Trust
2022
S.P.E.C.I.E.S.
2022
Island Institute
2022
Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D–binding protein has not been considered in the assessment vitamin deficiency.
Background— An imbalance in circulating angiogenic factors plays a central role the pathogenesis of preeclampsia. Methods and Results— We prospectively studied 616 women who were evaluated for suspected measured plasma levels antiangiogenic soluble fms-like tyrosine kinase 1 (sFlt1) proangiogenic placental growth factor (PlGF) at presentation examined an association between sFlt1/PlGF ratio subsequent adverse maternal perinatal outcomes within 2 weeks. The median was elevated participants...
Abstract Studies examining the relationship between total circulating 25-hydroxyvitamin D [25(OH)D] levels and bone mineral density (BMD) have yielded mixed results. Vitamin D–binding protein (DBP), major carrier for 25(OH)D, may alter biologic activity of vitamin D. We hypothesized that free bioavailable calculated from DBP, serum albumin levels, would be more strongly associated with BMD than 25(OH)D. measured in 49 healthy young adults enrolled Metabolic Abnormalities College-Aged...
OBJECTIVE To characterize physiologic subtypes of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS Insulin sensitivity and secretion were estimated in 809 women at 24–30 weeks' gestation, using oral glucose tolerance test–based indices. In with GDM (8.3%), defects insulin or defined below the 25th percentile normal (NGT). based on defect(s) present. RESULTS Relative to NGT, predominant (51% GDM) had higher BMI fasting glucose, larger infants (birth weight z score 0.57 [−0.01...
<h3>Importance</h3> Gestational diabetes, which increases the risk of adverse pregnancy outcomes, has been increasing in frequency across all racial and ethnic subgroups US. <h3>Objective</h3> To assess whether outcomes among those US with gestational diabetes changed over time these differed by maternal race ethnicity. <h3>Design, Setting, Participants</h3> Exploratory serial, cross-sectional, descriptive study using National Center for Health Statistics natality data 1 560 822 individuals...
Abstract During human evolutionary history, and for many around the world, breast milk is primary source of nutritional energy infants. Variation in quality might logically have important effects on infant health, growth, development, yet sources this variation remain largely unelucidated. We quantified nutrient content from 25 healthy, well‐nourished Massachusetts mothers with infants aged 2–5 months. examined several potential quality, particularly feeding patterns, sex, maternal growth...
Previous studies report an association between vitamin D deficiency and hypertension, including the pregnancy-specific disorder preeclampsia. Circulating is almost entirely bound to binding protein, which increases 2-fold during pregnancy previous have not examined protein or free levels. We performed a nested case-control study within Massachusetts General Hospital Obstetric Maternal Study, measuring first trimester total 25-hydroxyvitamin (25[OH]D) calculating 25(OH)D compared these levels...
Objective: To compare the clinical characteristics and outcomes of preeclamptic women presenting with a normal plasma angiogenic profile those subjects who are characterized by an abnormal profile. Methods: This was secondary analysis prospective cohort study in to obstetrical triage at <37 weeks gestation diagnosed preeclampsia within 2 enrollment whom factors (sFlt1 PlGF) measurements were available. Patients divided into two groups based on their circulating levels these described as...
24,25-Dihydroxyvitamin D [24,25(OH)2D] is a metabolite of 25-hydroxyvitamin (25D). Blacks frequently have low total 25D without manifestations vitamin deficiency, suggesting that serum may incorrectly reflect status in different racial groups. The ratio 24,25(OH)2D to [vitamin (VMR)] represents new candidate biomarker for status.We measured 24,25(OH)2D3 and 25D3 by mass spectrometry random community cohort black (n = 212) white 164) Americans evaluate VMR as marker status. We parathyroid...
Abstract Reduced insulin sensitivity (insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes mellitus (GDM). We conducted transcriptomic profiling 434 human placentas identified positive association between insulin-like growth factor binding protein 1 gene ( IGFBP1 ) expression the placenta at ~26 weeks gestation. Circulating levels rose over course declined postpartum, which, together with high our samples, suggests placental or...
OBJECTIVE To examine the accuracy of different periods continuous glucose monitoring (CGM), hemoglobin A1c (HbA1c), and their combination for estimating mean glycemia over 90 days (AG90). RESEARCH DESIGN AND METHODS We retrospectively studied 985 CGM with &lt;10% missing data from 315 adults (86% whom had type 1 diabetes) paired HbA1c measurements. The impact red blood cell age as a proxy nonglycemic effects on was estimated using published theoretical models in comparison empirical...
African Americans have a markedly higher incidence of ESRD compared with other racial groups. Two variants in the APOL1 gene, to date observed only among individuals recent ancestry, associate increased risk for renal disease Americans. Here, we investigated whether these alleles also age at initiation chronic hemodialysis. We performed cross-sectional study 407 nondiabetic who participated Accelerated Mortality on Renal Replacement (ArMORR) study, prospective cohort incident hemodialysis...
The National Institute of Diabetes and Digestive Kidney Diseases convened a workshop on research gaps in gestational diabetes mellitus (GDM) with focus 1) early pregnancy diagnosis treatment 2) pharmacologic strategies. This article summarizes the proceedings workshop. In pregnancy, appropriate diagnostic criteria for GDM remain poorly defined, an effect risk adverse outcomes has not been demonstrated. Despite many small randomized controlled trials glucose-lowering medication GDM, our...
The effect of clinically recovered AKI (r-AKI) on future pregnancy outcomes is unknown. We retrospectively studied all women who delivered infants between 1998 and 2007 at Massachusetts General Hospital to assess whether a previous episode r-AKI associated with subsequent adverse maternal fetal outcomes, including preeclampsia. was defined as rise in serum creatinine concentration 1.5-fold above baseline. compared without history CKD (eGFR>90 ml/min per 1.73 m
To evaluate changes in insulin physiology euglycemic pregnancy and gestational diabetes mellitus (GDM).Participants underwent oral glucose tolerance tests at ≤15 weeks' gestation (early pregnancy), 24-32 (mid-late 6-24 weeks postpartum. We evaluated longitudinal secretory response (log Stumvoll first-phase estimate) sensitivity Matsuda index) using linear mixed models. then participants who met GDM criteria early GDM) mid-late (classic separately from those without GDM. derived the (PIP)...