Maged M. Costantine
A5011042269- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Pregnancy and Medication Impact
- Maternal and fetal healthcare
- COVID-19 Impact on Reproduction
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiovascular Issues in Pregnancy
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
- Pregnancy-related medical research
- Reproductive System and Pregnancy
- Prenatal Substance Exposure Effects
- Global Maternal and Child Health
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Cardiac, Anesthesia and Surgical Outcomes
- Vaccine Coverage and Hesitancy
- Fatty Acid Research and Health
- Trauma and Emergency Care Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Bariatric Surgery and Outcomes
- Systemic Lupus Erythematosus Research
- Opioid Use Disorder Treatment
The Ohio State University
2019-2025
The Ohio State University Wexner Medical Center
2020-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2009-2024
Island Institute
2024
Office of the Director
2024
University of Utah
2022-2024
Duke University
2022-2024
University of North Carolina at Chapel Hill
2022-2024
University of Alabama at Birmingham
2022-2024
MetroHealth Medical Center
2024
OBJECTIVE: To describe coronavirus disease 2019 (COVID-19) severity in pregnant patients and evaluate the association between perinatal outcomes. METHODS: We conducted an observational cohort study of all with a singleton gestation positive test result for severe acute respiratory syndrome 2 (SARS-CoV-2) who delivered at 1 33 U.S. hospitals 14 states from March to July 31, 2020. Disease was classified by National Institutes Health criteria. Maternal, fetal, neonatal outcomes were abstracted...
Although much progress is being made in understanding the molecular pathways placenta that are involved pathophysiology of pregnancy-related disorders, a significant gap exists utilization this information for development new drug therapies to improve pregnancy outcome. On March 5-6, 2015, Eunice Kennedy Shriver National Institute Child Health and Human Development Institutes sponsored 2-day workshop titled Placental Origins Adverse Pregnancy Outcomes: Potential Molecular Targets begin...
It remains unknown whether SARS-CoV-2 infection specifically increases the risk of serious obstetric morbidity. To evaluate association with maternal morbidity or mortality from common complications. Retrospective cohort study 14 104 pregnant and postpartum patients delivered between March 1, 2020, December 31, 2020 (with final follow-up to February 11, 2021), at 17 US hospitals participating in Eunice Kennedy Shriver National Institute Child Health Human Development's Gestational Research...
Primary cytomegalovirus (CMV) infection during pregnancy carries a risk of congenital and possible severe sequelae. There is no established intervention for preventing CMV infection.
To assess the frequency and associated characteristics of COVID-19 vaccine hesitancy among pregnant postpartum individuals.Cross-sectional study.Prenatal care at a single academic tertiary centre.Pregnant individuals enrolled in prenatal centre from 22 March 2021 to 2 April 2021, concurrent with state guidelines recommending vaccination pregnancy.We used logistic regression identify hesitancy, adjusted for: age, parity, race, trimester pregnancy, chronic comorbidities.COVID-19 defined as...
<h3>Importance</h3> Gestational diabetes, which increases the risk of adverse pregnancy outcomes, has been increasing in frequency across all racial and ethnic subgroups US. <h3>Objective</h3> To assess whether outcomes among those US with gestational diabetes changed over time these differed by maternal race ethnicity. <h3>Design, Setting, Participants</h3> Exploratory serial, cross-sectional, descriptive study using National Center for Health Statistics natality data 1 560 822 individuals...
BACKGROUND: Among women with hypertensive disorders of pregnancy, biomarkers may stratify risk for developing preeclampsia severe features (sPE). METHODS: Across 18 U.S. centers, we prospectively measured the ratio serum soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) in pregnant hospitalized between 23 and 35 weeks gestation. The primary outcome was predicting sPE, secondary outcomes included adverse within 2 weeks. prognostic performance sFlt-1:PlGF assessed...
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms other health effects after the acute phase of infection; termed post-acute sequelae (PASC), long COVID. The characteristics, prevalence, trajectory and mechanisms PASC are ill-defined. objectives Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study Adults (RECOVER-Adult) to: (1) characterize prevalence; (2) symptoms, organ dysfunction, natural history, distinct phenotypes PASC; (3)...
Importance A short cervix as assessed by transvaginal ultrasound is an established risk factor for preterm birth. Study findings a cervical pessary to prevent delivery in singleton pregnancies with evidence of have been conflicting. Objective To determine if placement decreases the birth or fetal death prior 37 weeks among individuals cervix. Design, Setting, and Participants We performed multicenter, randomized, unmasked trial comparing vs usual care from February 2017 through November 5,...
There are currently no validated clinical biomarkers of postacute sequelae SARS-CoV-2 infection (PASC).
Major depressive disorder is a common in pregnancy. Although citalopram/escitalopram the second most frequently prescribed antidepressant for pregnant people, information about its pharmacokinetics pregnancy limited. We investigated plasma (S) ‐citalopram concentration to dose (C/D) ratios across and postpartum effect of pharmacogenetics on elimination. This prospective observational cohort study enrolled 30 participants with singleton who chose continue during prior diagnosis major...
To estimate the effects of pravastatin on altered vascular function in a mouse model preeclampsia induced by overexpression soluble fms-like tyrosine kinase-1 (sFlt-1).Pregnant CD1 mice, at day 8 gestation, were randomly allocated to injection using tail vein adenovirus carrying sFlt-1 (10 plaque-forming units 100 microliters; group) or mFc units) as virus control, and then receive (Pra; 5 mg/kg/d) dissolved drinking water control. The mice four groups (sFlt-1, sFlt-1-pravastatin, mFc,...