A5036200742- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Neonatal Health and Biochemistry
- Toxoplasma gondii Research Studies
- Pediatric health and respiratory diseases
- Legionella and Acanthamoeba research
- Reproductive tract infections research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infant Nutrition and Health
- Respiratory viral infections research
- Renal Transplantation Outcomes and Treatments
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Hepatitis Viruses Studies and Epidemiology
- Polyomavirus and related diseases
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- HIV/AIDS Research and Interventions
- Neonatal and Maternal Infections
- Viral-associated cancers and disorders
- Salivary Gland Disorders and Functions
- Adolescent Sexual and Reproductive Health
- COVID-19 Impact on Reproduction
- Immune Response and Inflammation
University of Alabama at Birmingham
2013-2025
University of Alabama at Birmingham Hospital
1978-2023
Children's of Alabama
1983-2022
The University of Texas Southwestern Medical Center
2003-2022
Memorial Hermann
2022
Northwestern University
2022
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2022
Columbia University
2022
University of Utah
2022
University of North Carolina at Chapel Hill
2022
Intrauterine transmission of cytomegalovirus (CMV) can occur whether a mother has prior immunity or acquires CMV for the first time during pregnancy. The degree protection afforded an infected infant by presence antibody in before conception is uncertain.
Background. Cytomegalovirus (CMV) is a leading cause of congenital illness and disability, including hearing loss mental retardation. However, there are no nationwide estimates CMV seroprevalence among pregnant women or the overall population United States.
Congenital infection with cytomegalovirus (CMV) is an important cause of hearing, cognitive, and motor impairments in newborns.
We studied the incidence of primary and recurrent cytomegalovirus infection in 3712 pregnant women —2698 middle to high income 1014 low — determine whether there were differences effects on fetus. In higher-income group, 1203 (45 per cent) did not have antibodies therefore susceptible infection, as compared with 179 (18 income. Congenital occurred more often (1.6 vs. 0.6 infants low-income group. this group it was associated maternal (in 82 than whereas upper-income half cases. Altogether,...
Knowledge of the natural history symptomatic congenital cytomegalovirus (CMV) infection in newborn is essential order to anticipate complications and assess potential benefit from antiviral therapy. To define disease course we reviewed data on 106 neonates with CMV diagnosed managed by investigators. Petechiae, jaundice hepatosplenomegaly were each noted 70% or more patients. Microcephaly was 54 102 (53%) at birth.
Context Vaccine development to prevent congenital cytomegalovirus (CMV) infection has been impeded by the uncertainty over whether maternal immunity protects fetus. Objective To determine presence of antibodies CMV significantly reduces risk in future pregnancies. Design, Setting, and Participants Cohort study 3461 multiparous women from a population with high rate who delivered newborns screened for between 1993 1998, whose cord serum specimen previous delivery could be retrieved tested...
Thirty-four patients with congenital cytomegalovirus infection who were symptomatic as newborns followed in a special clinic providing periodic medical and visual examinations well psychometric testing audiometry. All had symptoms of by 2 weeks age, 31 34 virus isolated from urine within the first month life. Age at latest follow-up varied 9 months to 14 years mean about 4 years. Ten died 23 surviving adequate examinations; all but two evidence central nervous system or auditory handicaps....
This investigation consisted of a longitudinal study the effects congenital cytomegalovirus (CMV) infection on hearing sensitivity in 860 children with documented asymptomatic or symptomatic CMV infection. Of 651 infection, 48 (7.4%) developed sensorineural loss (SNHL), compared to 85 (40.7%) Children both groups experienced latent consisting delayed onset loss, threshold fluctuations, and/or progressive hearing. It can be concluded that is leading cause SNHL children. The late and...
Objectives. To determine the frequency of symptomatic congenital cytomegalovirus (CMV) infection in offspring women with a recurrent maternal CMV and to characterize demographic newborn findings. Methods. Study subjects consisted infants identified by virologic screening program at University Alabama Hospital between 1991 1997 were enrolled long-term follow-up study. Maternal infections categorized an analysis archival serum specimens collected before pregnancy time delivery. Demographic...
DESPITE increasing interest, the modes of transmission cytomegalovirus (CMV) infection, particularly in first year life, remain ill-defined. During rate acquisition CMV infection throughout world is variable but high, as summarized Table 1.1-10 In populations different ethnic and socioeconomic backgrounds, from 8 to 60 per cent infants begin shedding virus into urine during year. Intrauterine transmission, although common (it accounts for 0.4 2.5 cases), cannot account high rates perinatal...
Primary cytomegalovirus (CMV) infection during pregnancy carries a risk of congenital and possible severe sequelae. There is no established intervention for preventing CMV infection.
Congenital cytomegalovirus (CMV) infection occurs in ∼1% of newborns the United States. A phase II evaluation was done ganciclovir for treatment symptomatic congenital CMV infection. Daily doses 8 or 12 mg/kg were administered divided at 12-h intervals 6 weeks. Clinical and laboratory evaluations sought evidence toxicity, quantitative virologic responses urine, plasma drug concentrations, clinical outcome. total 14 28 babies received mg/kg/day, respectively. Five additional on a...
Of unselected postpartum women, 39% reactivated cytomegalovirus in breast milk, vaginal secretions, urine, and/or saliva. Consumption of infected milk led to infection 69% the infants. Although there was some secretory immune response this virus, it prevented neither viral shedding nor transmission. All infants chronically shed cytomegalovirus. However, no have yet demonstrated chronic sequelae. Two preterm did develop a significantly acute problem, pneumonitis, which resolve. The...
Objective. To determine whether newborn cranial computed tomographic (CT) scan abnormalities predict an adverse neurodevelopmental outcome in children with symptomatic congenital cytomegalovirus (CMV) infection and to examine the association between clinical findings at birth imaging abnormalities. Methods. The data from 56 CMV who underwent CT scans as newborns were enrolled a long-term follow-up study analyzed. incidence of sequelae was compared groups normal abnormal studies. relationship...
A phase I randomized, double-blind, placebo-controlled trial was done with a cytomegalovirus (CMV) vaccine based on the envelope glycoprotein, gB, combined novel adjuvant, MF59. Participants received CMV gB MF59 or alum placebo at 0, 1, and 6 months. fourth given 12 months to subgroup. Levels of neutralizing antibody 2 weeks after third dose exceeded those in seropositive control subjects, formulation more immunogenic than that alum. The optimal appeared be between 5 30 μg. produced prompt...
We followed 45 seronegative adolescents for acquisition of cytomegalovirus (CMV); 6 (5 female, 1 male) seroconverted after a median 7.5 months. All were free signs and symptoms. CMV was isolated from 32 (59.2%) 54 urines, 2–80 weeks infection; viruria less frequent saliva 3 subjects, vaginal swabs 2 5, white blood cell (WBC) sample. DNA detected by polymerase chain reaction in WBCs plasma all subjects tested. The proportion WBC samples with DNAemia 75%–80% within 16 infection, declining to...