A5057853240- Potassium and Related Disorders
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Electrolyte and hormonal disorders
- Renal Transplantation Outcomes and Treatments
- Complement system in diseases
- Medical Imaging and Pathology Studies
- Hormonal Regulation and Hypertension
- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- Renal function and acid-base balance
- Pharmacological Effects and Toxicity Studies
- Medical and Health Sciences Research
- Restless Legs Syndrome Research
- Acute Kidney Injury Research
- Organ Donation and Transplantation
- Cardiac pacing and defibrillation studies
- Pregnancy and Medication Impact
- Magnesium in Health and Disease
- Iron Metabolism and Disorders
- Hepatitis C virus research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pneumothorax, Barotrauma, Emphysema
- Oral and Craniofacial Lesions
- Oral and Maxillofacial Pathology
Solothurner Spitäler
2014-2022
Schweizerische Ärztegesellschaft für Psycholytische Therapie
2020
University Hospital of Bern
2006-2015
University of Bern
2005-2013
St. Paul's Hospital
2012
Institute for Biomedical Engineering
2012
Medical University of Vienna
2009
Hypertension Institute
2009
Istituto di Sessuologia Clinica
1997
Vascular and soft tissue calcification contributes to cardiovascular morbidity mortality in both the general population CKD. Because calcium phosphate serum concentrations are near supersaturation, balance of inhibitors promoters critically influences development calcification. An assay that measures overall propensity for occur may have clinical use. Here, we describe a nanoparticle-based detects, presence artificially elevated concentrations, spontaneous transformation spherical colloidal...
Medial arterial calcification is accelerated in patients with CKD and strongly associated increased rigidity cardiovascular mortality. Recently, a novel vitro blood test that provides an overall measure of propensity by monitoring the maturation time (T50) calciprotein particles serum was described. We used this to T50 prospective cohort 184 stages 3 4 CKD, median 5.3 years follow-up. At baseline, major determinants included higher phosphate, ionized calcium, bone osteoclastic activity,...
Calciprotein particle maturation time (T50) in serum is a novel measure of individual blood calcification propensity. To determine the clinical relevance T50 renal transplantation, baseline was measured longitudinal cohort 699 stable transplant recipients and associations with mortality graft failure were analyzed over median follow-up 3.1 years. Predictive value assessed for patient survival reference to traditional (Framingham) risk factors calcium-phosphate product. Serum magnesium,...
To our knowledge, no study to date has compared the effects of a subunit influenza vaccine with those virosomal on immunocompromised patients.A prospective, double-blind, randomized was conducted compare immunogenicity and reactogenicity vaccines for adult patients who had an immunosuppressive disease or were as result treatment.There 304 enrolled in study: 131 human immunodeficiency virus (HIV) infection, 47 chronic rheumatologic disease, 74 underwent renal transplant, received long-term...
Summary Background and objectives Vascular calcification is a major cause of morbidity mortality in dialysis patients. Human animal studies indicate that sodium thiosulfate (STS) may prevent the progression vascular calcifications. The pharmacokinetics STS hemodialysis patients has not been investigated yet. Design, setting, participants, & measurements was given intravenously to 10 on- off-hemodialysis. Additionally, applied 9 healthy volunteers once orally. Thiosulfate concentrations...
Abstract Intermittent and continuous renal replacement therapies (RRTs) are available for the treatment of acute failure (ARF) in intensive care unit (ICU). Although at present there no adequately powered survival studies, data suggest that both methods equal with respect to patient outcome. Therefore, cost comparison between techniques is important selecting modality. Expenditures were prospectively assessed as a secondary end point during controlled, randomized trial comparing intermittent...
Nocturnal nondipping is a feature of salt-sensitive, hypertensive individuals. In normotensive children and adults, the impact salt intake on circadian blood pressure (BP) rhythm not well defined.To test whether high-salt diet abolishes nocturnal dipping in individuals.In normotensive, healthy individuals dichotomized for age (children: n = 28, 11.9 +/- 0.8 years, 43% girls; adults: 41, 25.7 0.9 46% women), 24-h ambulatory BP monitoring was performed urine collections were obtained during...
Background. To cover the shortage of cadaveric organs, new approaches to expand donor pool are needed. Here we report on a case domino liver transplantation (DLT) using an organ harvested from compound heterozygous patient with primary hyperoxaluria (PHO), who underwent combined and kidney transplantation. The DLT recipient developed early renal failure oxaluria. time progression oxalosis in such situations is unknown, but, based animal data, hypothesize that calcineurin inhibitors may play...
Volume expansion in the presence of elevated aldosterone availability is a hallmark normal pregnancy. Intravascular volume depletion characterizes severe pregnancy-associated disease conditions such as intra-uterine growth retardation, chronic hypertension or pre-eclampsia [1]. Two hypotheses have been forwarded to explain pregnancy: first hypothesis charges inappropriate sensing vascular ‘overfilling’, resulting an increased transendothelial loss fluid extravascular compartment. In...
Erythromycin has been shown to be a powerful prokinetic of the gastrointestinal tract. Little is known about its value improve motility and transit in gastrectomized patients.Thirteen disease-free patients subjected subtotal gastrectomy 11 total for gastric cancer entered study. Gastrointestinal standard 99mTc-labelled meal fasting were studied before after oral erythromycin.In who had mean(s.d.) half-emptying time was 42(14) min 26(11) erythromycin (P = 0.011). Before prolonged rhythmical...
Background. Early and long-term use of cyclosporine A (CsA) leads to increased risks renal toxicity. We hypothesized that administration daclizumab in combination with mycophenolate mofetil (MMF) allows a relevant reduction the dose CsA.
1 IntroductionSevere COVID‐19 is associated with an important increase of von Willebrand factor and mild lowering ADAMTS13 activity that may, in the presence a strong inflammatory reaction, risk acute thrombotic thrombocytopenic purpura (TTP). Although episodes immune‐mediated TTP or SARS‐CoV‐2 vaccination have been reported, data about clinical evolution hereditary (hTTP) during pandemic are scarce.2 MethodWe conducted survey among adult patients International Hereditary Registry...
Mycophenolic acid (MPA), either given as an ester pro-drug or enteric-coated sodium salt, is the most commonly prescribed anti-proliferative immunosuppressive agent used following organ transplantation and widely applied in immune-mediated diseases. Clinicians are well aware of common adverse reactions related to MPA treatment, particular diarrhea, leukopenia infections. Here we report a case severe, persistent ascites associated with treatment. The otherwise unexplained intractable ascites,...
Abstract The Hereditary TTP Registry is an international cohort study for patients with a confirmed or suspected diagnosis of hereditary thrombotic thrombocytopenic purpura (hTTP) and their family members. ultra-rare blood disorder (prevalence ∼1–2 cases per million), the result autosomal-recessively inherited congenital ADAMTS13 (a disintegrin metalloproteinase thrombospondin type 1 motif, member 13) deficiency (ADAMTS13 activity <10% normal), associated yet many unanswered questions....
Marfan's syndrome is caused by mutations in the extracellular matrix protein fibrillin-1 with aortic aneurysm and dissection being its most life-threatening manifestations. Kidney transplantation from donors has never been reported literature, possibly because of reticences due to underlying connective tissue disease. Here, we report two patients end-stage renal disease, transplanted kidneys a donor who died cerebral hemorrhage. After delayed graft function both recipients, normalized no...
In chronic haemodialysis patients, anaemia is a frequent finding associated with high therapeutic costs and further expenses resulting from serial laboratory measurements. HemoHue HH1, Ltd, novel tool consisting of visual scale for the noninvasive assessment by matching coloration conjunctiva calibrated hue scale. The aim study was to investigate usefulness in estimating individual haemoglobin concentrations binary treatment outcomes patients. A prospective blinded 80 hemodialysis patients...
Introduction and Aims: Dialysis patients have loss of glycocalyx barrier properties increased levels its constituents in blood.The endothelial is a negatively charged mesh glycoproteins, proteoglycans glycosaminoglycans lining the luminal side blood vessels.It able to reversibly bind positively sodium ions from circulation might act as buffer.As consequence, reduction components result an alteration buffering capacity.Our aim was investigate role fluid overload hemodialysis patients.Methods:...