A5082008328- Acute Ischemic Stroke Management
- Muscle activation and electromyography studies
- Peripheral Neuropathies and Disorders
- Transcranial Magnetic Stimulation Studies
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Multiple Sclerosis Research Studies
- EEG and Brain-Computer Interfaces
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and exercise physiology
- Long-Term Effects of COVID-19
- Nerve Injury and Rehabilitation
- Migraine and Headache Studies
- Functional Brain Connectivity Studies
- Stroke Rehabilitation and Recovery
- Epilepsy research and treatment
- Brain Metastases and Treatment
- Neuroscience and Neural Engineering
- Health and Medical Studies
- Peripheral Nerve Disorders
- Health, Environment, Cognitive Aging
- Infectious Encephalopathies and Encephalitis
- Neural dynamics and brain function
- Obstructive Sleep Apnea Research
- Ophthalmology and Eye Disorders
Fribourg Development Agency
2012-2025
University of Fribourg
2023
Réseau Fribourgeois de Santé Mentale
2021
HFR Freiburg Kantonsspital
2021
Schweizerischen Neurologischen Gesellschaft
2021
University of Bern
2003-2017
University Hospital of Bern
2002-2017
National Hospital for Neurology and Neurosurgery
2008-2010
University College London
2008-2010
St Mary's Hospital
2010
In the wake of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increasing number patients with neurological disorders, including Guillain-Barré (GBS), have been reported following this infection. It remains unclear, however, if these cases are coincidental or not, as most publications were case reports small regional retrospective cohort studies. The International GBS Outcome Study is ongoing prospective observational study enrolling within weeks from onset...
Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown.
The brain and its health are essential for our (physical mental, social, spiritual) wellbeing, being able to realize potential as individuals, also a fair, well-functioning, productive society. However, today the world is facing healthcare crisis related very high (and increasing) burden of disorders. As response this crisis, “Swiss Brain Health Plan” (SBHP) was conceptualized in context other initiatives launched value, promote, protect over entire life course. In first section position...
Importance The net clinical effect of early vs later direct oral anticoagulant (DOAC) initiation after atrial fibrillation–associated ischemic stroke is unclear. Objective To investigate whether DOAC treatment associated with a benefit (NCB). Design, Setting, and Participants This was post hoc analysis the Early Versus Late Initiation Direct Oral Anticoagulants in Post–Ischaemic Stroke Patients With Atrial Fibrillation (ELAN) open-label randomized trial conducted across 103 sites 15...
Introduction: Sex differences in stroke incidence, vascular risk factors (VRFs), and etiologies among young adults remain underexplored, particularly regarding age-related patterns. Patients Methods: We retrospectively analyzed (18–55 years) with first-ever ischemic treated at certified acute units/centers between 2014 2022, using Swiss Stroke Registry data. rates (per 100,000 person-years), VRFs, were assessed by age sex. Results: Among 3,995 patients, similar sexes until 35, after which...
A 58-year old woman with a long-standing history of chronic recurrent headache, depression and anxiety presented new onset occipital headaches, tinnitus, gait instability worsening mood disorder.A first extensive work-up failed to objectify somatic disorder psychiatric origin was suspected.However, 6 weeks later focal neurological deficits including complex visual disturbances, seizures nd cognitive decline appeared, initially parallelled by fever.Cerebrospinal fluid (CSF) analysis showed...
Acute hepatitis E virus (HEV) infection has recently emerged as a potential trigger for acute dysimmune neuropathies, but prospective controlled studies are lacking.
To determine the frequency, age distribution and clinical presentation of carotid sinus hypersensitivity (CSH) among 373 patients (age range 15-92 years) referred to two autonomic referral centres during a 10-year period.Carotid massage (CSM) was performed both supine 60 degree head-up tilt. Beat-to-beat blood pressure, heart rate three-lead electrocardiography were recorded continuously. CSH classified as cardioinhibitory (asystole > or = 3 s), vasodepressor (systolic pressure fall 50 mm...
<h3>Objective</h3> Patients with orthostatic hypotension may experience neck pain radiating to the occipital region of skull and shoulders while standing (so-called coat-hanger ache). This study assessed muscle membrane potential in trapezius patients healthy subjects during head-up tilt (HUT), by measuring velocity recovery cycles (VRCs) action potentials as an indicator potential. <h3>Methods</h3> Eight multiple system atrophy (MSA), a positive history for eight normal controls (NCs) were...
Background: Rapid water ingestion improves orthostatic intolerance (OI) in multiple system atrophy (MSA) and postural tachycardia syndrome (PoTS). We compared haemodynamic changes after clear soup intake, the latter being a common treatment strategy for OI daily practice. Methods: Seven MSA seven PoTS patients underwent head‐up tilt (HUT) without fluid intake 30 min drinking 450 ml of soup, respectively. All suffered from moderate to severe because neurogenic hypotension (OH) excessive heart...
<b>Objective:</b> To compare the effects of intravenous methylprednisolone (IVMP) in patients with relapsing-remitting (RR-MS), secondary progressive (SP-MS), and primary multiple sclerosis (PP-MS). <b>Methods:</b> Clinical neurophysiological follow up was undertaken 24 RR-MS, eight SP-MS, nine PP-MS receiving Solu-Medrol 500 mg/d over five days for exacerbations involving motor system. Motor evoked potentials (MEPs) were used to measure central conduction time (CMCT) triple stimulation...
Patients with pure autonomic failure (PAF) have an abnormal fall in blood pressure (BP) supine exercise and exacerbation of orthostatic hypotension (OH) after exercise. This study assessed the pressor effect water on cardiovascular responses to OH exercise.8 patients PAF underwent a test protocol consisting standing for 5 min, rest 10 by pedalling cycle ergometer at workloads 25, 50 75 W (each 3 min), min min. The was performed without ingestion separate occasion 480 ml distilled immediately...
Carotid sinus massage (CSM) is commonly used to identify carotid hypersensitivity (CSH) as a possible cause for syncope, especially in older patients. However, CSM itself could provoke classical vasovagal syncope (VVS) pre disposed subjects.Retrospective analysis of CSM, cardiovascular autonomic function tests (including tilt table testing) and medical history 388 patients with recurrent characterize whom an abnormal response was more likely reflect VVS than CSH.CSM 79 In 53 (77.2 +/- 8.7...
In Switzerland, the COVID-19 incidence during first pandemic wave was high. Our aim to assess association of outbreak with acute stroke care in Switzerland spring 2020.This a retrospective analysis based on Swiss Stroke Registry, which includes consecutive patients cerebrovascular events admitted Units and Centers. A linear model fitted weekly admission from 2018 2019 used quantify deviations expected admissions 13 March 26 April 2020 (the "lockdown period"). Characteristics 3-month outcome...
Abstract Background and purpose Infections vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type frequency preceding agents is unknown. Methods This was a multicentre, prospective, observational, matched case–control study. NA diagnosed by neuromuscular experts according to validated clinical criteria electrodiagnostic studies. Clinical data biological samples patients were collected within 90 days from disease onset between...
Abstract Background INCbase is an international, multicenter prospective observational study using a customizable web-based modular registry to the clinical, biological and electrophysiological variation boundaries of chronic inflammatory demyelinating polyneuropathy (CIDP). The primary objective develop validate clinical prediction model for treatment response. Methods All patients meeting criteria CIDP can be included in INCbase. Collected data include demographics, history, diagnostics...
Velocity recovery cycles (VRCs) of human muscle action potentials have been proposed as a new technique for studying membrane function. This study was undertaken to determine the temperature dependency VRC parameters.VRCs with 1 conditioning stimulus were recorded repeatedly from brachioradialis during cooling, and intramuscular recorded. VRCs in 6 normal volunteers measured at 1°C intervals 34°C 28°C. The effects on relative refractory period early late supernormality quantified.Muscle...
Harlequin syndrome is a rare autonomic disorder referring to the sudden development of flushing and sweating limited one side face. Like Horner syndrome, associating miosis, ptosis, anhidrosis, caused by disruption cervical sympathetic pathways. Authors this report describe case 55-year-old female who presented with both sign immediately after anterior discectomy (C6–7) cage fusion spondylodesis. They discuss pathophysiology underlying striking phenomenon benign course condition. Familiarity...