Carlo W. Cereda
A5078770537- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Obstructive Sleep Apnea Research
- Long-Term Effects of COVID-19
- Cardiac Imaging and Diagnostics
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disorders and Treatments
- Advanced MRI Techniques and Applications
- COVID-19 and healthcare impacts
- Extracellular vesicles in disease
- Health, Medicine and Society
- Peripheral Artery Disease Management
- Retinal and Optic Conditions
- Cardiac Arrhythmias and Treatments
- Neurology and Historical Studies
- Cardiovascular and Diving-Related Complications
- Cardiovascular Health and Disease Prevention
- Antiplatelet Therapy and Cardiovascular Diseases
- Takotsubo Cardiomyopathy and Associated Phenomena
- Neuroscience of respiration and sleep
Laboratory for Biomedical Neurosciences
2012-2025
Ente Ospedaliero Cantonale
2020-2025
Università della Svizzera italiana
2012-2025
Ospedale regionale di Lugano
2015-2024
Policlinico Umberto I
2024
Sapienza University of Rome
2024
University of Florence
2024
McMaster University
2018-2024
Population Health Research Institute
2024
University of Liverpool
2024
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
International guidelines recommend avoiding intravenous thrombolysis (IVT) in patients with ischemic stroke who have a recent intake of direct oral anticoagulant (DOAC). To determine the risk symptomatic intracranial hemorrhage (sICH) associated use IVT DOAC ingestion. This international, multicenter, retrospective cohort study included 64 primary and comprehensive centers across Europe, Asia, Australia, New Zealand. Consecutive adult received (both without thrombectomy) were included....
To characterize clinically acute insular strokes from four patients with a first ever stroke restricted to the insula on MRI.The authors studied clinical presentation of found five main groups presentations: 1) somatosensory deficits in three posterior (two transient pseudothalamic sensory syndrome, one partial distribution); 2) gustatory disorder patient left infarct; 3) vestibular-like dizziness, gait instability, and tendency fall, but no nystagmus, strokes; 4) cardiovascular...
Background and purpose Risk factors for IS in young adults differ between genders evolve with age, but data on the age‐ gender‐specific differences by stroke etiology are scare. These features were compared based individual patient from 15 European centers. Methods Stroke was reported detail 3331 patients aged 15–49 years first‐ever according to Trial of Org Acute Treatment ( TOAST ) criteria: large‐artery atherosclerosis LAA ), cardioembolism CE small‐vessel occlusion SVO other determined...
Differences in research methodology have hampered the optimization of Computer Tomography Perfusion (CTP) for identification ischemic core. We aim to optimize CTP core using a novel benchmarking tool. The tool consists an imaging library and statistical analysis algorithm evaluate performance CTP. was used in-house developed CTP-software algorithm. Imaging data 103 acute stroke patients were included Median time from onset CT 185 min (IQR 180-238), median between completion start MRI 36...
We compared among young patients with ischemic stroke the distribution of vascular risk factors sex, age groups, and 3 distinct geographic regions in Europe.We included first-ever aged 15 to 49 years from existing hospital- or population-based prospective consecutive registries involving cities 12 countries. Geographic were defined as northern (Finland, Norway), central (Austria, Belgium, France, Germany, Hungary, The Netherlands, Switzerland), southern (Greece, Italy, Turkey) Europe....
<h3>Importance</h3> Predicting the duration of poststroke dysphagia is important to guide therapeutic decisions. Guidelines recommend nasogastric tube (NGT) feeding if swallowing impairment persists for 7 days or longer and percutaneous endoscopic gastrostomy (PEG) placement does not recover within 30 days, but, our knowledge, a systematic prediction method exist. <h3>Objective</h3> To develop validate prognostic model predicting recovery need enteral feeding. <h3>Design, Setting,...
The aim was to evaluate, in patients with atrial fibrillation (AF) and acute ischemic stroke, the association of prior anticoagulation vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) stroke severity, utilization intravenous thrombolysis (IVT), safety IVT, 3-month outcomes.This a cohort study consecutive (2014-2019) on versus those without (controls) regard rates IVT/mechanical thrombectomy, symptomatic intracranial hemorrhage (sICH), favorable outcome (modified Rankin...
To evaluate whether time to treatment modifies the effect of endovascular reperfusion in stroke patients with evidence salvageable tissue on MRI.
Abstract Aims Lipoprotein(a) [Lp(a)] is a recognized causal risk factor for atherosclerotic cardiovascular disease but its role acute ischaemic stroke (AIS) controversial. In this study, we evaluated the association of Lp(a) with large artery atherosclerosis (LAA) and recurrent cerebrovascular events in AIS patients. Methods results For analysis prospective, observational, multicentre BIOSIGNAL cohort study measured levels plasma samples 1733 primarily Caucasian (98.6%) patients, collected...
Background and Purpose: Stroke is reported as a consequence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in several reports. However, data are sparse regarding the details these patients multinational large scale. Methods: We conducted observational study on features consecutive ischemic stroke, intracranial hemorrhage, cerebral venous or sinus thrombosis among SARS-CoV-2–infected patients. further investigated risk vessel occlusion, stroke severity measured by...
To investigate the aetiology, subsequent preventive strategies and outcomes of stroke despite anticoagulation in patients with atrial fibrillation (AF). We analysed consecutive AF an index imaging-proven ischaemic vitamin K-antagonist (VKA) or direct oral anticoagulant (DOAC) treatment across 11 centres. classified aetiology as: (i) competing mechanism other than AF-related cardioembolism; (ii) insufficient (non-adherence low activity measured drug-specific assays); or, (iii) cardioembolism...
Background We investigated outcomes in patients with intracerebral haemorrhage (ICH) according to prior anticoagulation treatment Vitamin K antagonists (VKAs), direct oral anticoagulants (DOACs) or no anticoagulation. Methods This is an individual patient data study combining two prospective national stroke registries from Switzerland and Norway (2013–2019). included all consecutive ICH both registries. The main were favourable functional outcome (modified Rankin Scale 0–2) mortality at 3...
Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown.
To compare outcomes after endovascular therapy (EVT) and IV thrombolysis (IVT) in patients with stroke emergent large vessel occlusion (LVO) mild neurologic deficits.
<h3>Objective</h3> To develop a diagnostic model based on plasma-derived extracellular vesicle (EV) subpopulations in Parkinson disease (PD) and atypical parkinsonism (AP), we applied an innovative flow cytometric multiplex bead-based platform. <h3>Methods</h3> Plasma-derived EVs were isolated from PD, matched healthy controls, multiple system atrophy (MSA), AP with tauopathies (AP-Tau). The expression levels of 37 EV surface markers measured by cytometry correlated clinical scales. A was...
Background Identification of large vessel occlusion (LVO) is critical to the management acute ischemic stroke and prerequisite endovascular therapy in recent trials. Increasing volumes data complexity compel development fast, reliable, automated tools for LVO detection facilitate imaging triage. Purpose To investigate performance an anterior circulation platform a mixed sample individuals with without at cerebrovascular CT angiography (CTA). Materials Methods In this retrospective analysis,...
We assessed the efficacy and safety of mechanical thrombectomy (MT) in adult stroke patients with anterior circulation large vessel occlusion presenting late time window not fulfilling DEFUSE-3 (Thrombectomy for Stroke at 6 to 16 Hours With Selection by Perfusion Imaging trial) DAWN 24 After a Mismatch Between Deficit Infarct inclusion criteria.Cohort study adults admitted between hours after last-seen-well 5 participating Swiss centers 2014 2021. was computer tomography or magnetic...
Purpose: There is little data on the safety and efficacy of endovascular treatment (EVT) in comparison with intravenous thrombolysis (IVT) acute ischemic stroke due to isolated posterior cerebral artery occlusion (IPCAO). We aimed investigate functional outcomes patients IPCAO treated EVT (with or without prior bridging IVT) compared IVT alone. Methods: did a multicenter retrospective analysis from Swiss Stroke Registry. The primary endpoint was overall outcome at 3 months undergoing alone...
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Objective Perfusion imaging identifies anterior circulation stroke patients who respond favorably to endovascular thrombectomy (ET), but its role in basilar artery occlusion (BAO) is unknown. We hypothesized that BAO with limited regions of severe hypoperfusion (time reach maximum concentration seconds [Tmax] > 10) would have a favorable response ET compared more extensive involved. Methods performed multicenter retrospective cohort study perfusion prior ET. prespecified Critical Area...
<h3>Background and Objectives</h3> COVID-19–related inflammation, endothelial dysfunction, coagulopathy may increase the bleeding risk lower efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate safety outcomes AIS COVID-19. <h3>Methods</h3> This was a retrospective multicenter cohort study consecutive receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 June 2021 tested for severe respiratory...