A5020685129- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Acute Ischemic Stroke Management
- Aortic aneurysm repair treatments
- Pituitary Gland Disorders and Treatments
- Neurological Disorders and Treatments
- COVID-19 Clinical Research Studies
- Brain Metastases and Treatment
- Spinal Dysraphism and Malformations
- Long-Term Effects of COVID-19
- Surgical Simulation and Training
- Head and Neck Surgical Oncology
- Retinal and Optic Conditions
- Neuroinflammation and Neurodegeneration Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ocular Oncology and Treatments
University of Helsinki
2016-2025
Helsinki University Hospital
2016-2025
Scripps Clinic
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2023
Töölö Hospital
2016-2022
Lucerne University of Applied Sciences and Arts
2022
University of Eastern Finland
2016-2021
Northwestern University
2017-2020
Northwestern Memorial Hospital
2020
Henan Provincial People's Hospital
2018-2020
Sporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in brain vasculature, a leading cause hemorrhagic stroke young adults children. The genetic this rare focal disorder is unknown.
<h3>BACKGROUND AND PURPOSE:</h3> Saccular intracranial aneurysm is a common disease that may cause devastating hemorrhage. Hemodynamics, wall remodeling, and inflammation have been associated with saccular rupture. We investigated how hemodynamics remodeling of the wall. <h3>MATERIALS METHODS:</h3> Tissue samples resected during operation (11 unruptured, 9 ruptured) were studied histology immunohistochemistry. Patient-specific computational models created from preoperative CT angiographies....
OBJECTIVE Large consecutive series on the size and location of ruptured intracranial aneurysms (RIAs) are limited, therefore it has been difficult to estimate population-wide effects size-based treatment strategies unruptured aneurysms. The authors' aim was define RIAs in patients diagnosed with subarachnoid hemorrhage due aneurysm rupture a high-volume academic center. METHODS Consecutive admitted large nonprofit hospital saccular between 1995 2009 were identified, size, location,...
Background and Purpose: Stroke is reported as a consequence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in several reports. However, data are sparse regarding the details these patients multinational large scale. Methods: We conducted observational study on features consecutive ischemic stroke, intracranial hemorrhage, cerebral venous or sinus thrombosis among SARS-CoV-2–infected patients. further investigated risk vessel occlusion, stroke severity measured by...
Knowledge on a natural history of untreated ruptured intracranial aneurysms is based small historical cohort from 1960s. We calculated mortality rates for patients with using more recent and relatively large hospital cohort.Patients admitted to the study between 1968 2007 saccular but were identified aneurysm registry 6850 patients. The included only who followed up until death whom date symptom onset admission available.For 510 identified, median survival time was 20 days. 1-year rate 65%,...
BACKGROUND: Treatment of very small unruptured intracranial aneurysms (VSUIAs, defined as ≤3 mm) can be indicated in selected circumstances. The feasibility and outcomes endovascular therapy for VSUIAs have been recently published; however, the efficacy complication rate surgical clipping has not reported any large series to date. OBJECTIVE: We conducted a multicenter study examine VSUIAs. METHODS: All consecutive patients undergoing surgery VSUIA 4 neurosurgical centers between October 2001...
Cerebral Cavernous Malformation (CCM) is a brain vascular disease with various neurological symptoms. In this study, we describe the inflammatory profile in CCM and show for first time formation of neutrophil extracellular traps (NETs) rodents humans CCM. Through RNA-seq analysis cerebellum endothelial cells from wild-type mice an cell-specific ablation Ccm3 gene (Ccm3iECKO), that Ccm3iECKO have increased expression inflammation-related genes. These genes encode proinflammatory cytokines...
Posterior cerebral artery (PCA) aneurysms are rare lesions. Because of their low incidence, the individual or institutional experience is usually limited.To identify specific anatomic features related to PCA based on analyses pretreatment angiograms.We performed a detailed angiographic study 81 patients with diagnosis 93 aneurysms. Fifty-three underwent computed tomography angiography, 49 digital subtraction and 6 magnetic resonance angiography. Between 1980 2012, total 120 136 11 352 16 444...
Blebs are important secondary structures of intracranial aneurysms associated with increased rupture risk and can affect local wall stress hemodynamics. Mechanisms bleb development evolution not clearly understood. We investigate the relationship between blebs different characteristics hemodynamics sites.Blebs appearances in intra-operative videos were analyzed image-based computational fluid dynamics. Thin red compared against thick atherosclerotic/hyperplastic white/yellow blebs. Rupture...
Cerebral cavernous malformation (CCM) is a neurovascular disease that results in various neurological symptoms. Thrombi have been reported surgically resected CCM patient biopsies, but the molecular signatures of these thrombi remain elusive. Here, we investigated kinetics formation and how affect vasculature contribute to cerebral hypoxia. We used RNA sequencing investigate transcriptome mouse brain endothelial cells with an inducible endothelial-specific Ccm3 knock-out (Ccm3-iECKO). found...
INTRODUCTION: Intraventricular hemorrhage (IVH) often complicates spontaneous intracerebral (ICH) and subarachnoidal hemorrhages (SAH), leading to increased mortality morbidity. Neuroinflammation resulting from blood organization in cerebrospinal fluid (CSF) contributes poor outcomes. METHODS: Data were collected six centers the EU USA utilizing new active EVD system. Forty patients analyzed, including those with SAH, ICH-related IVH, vascular anomaly-related hemorrhage. Blood removal...
The basilar bifurcation aneurysm (BBA) is still considered to be one of the most challenging aneurysms for micro- and endovascular surgery. Classic surgical approaches, such as subtemporal, lateral supraorbital (LSO), modified presigmoid, are reliable effective.To analyze clinical radiological factors that affect selection these classic approaches their outcomes.A retrospective analysis was conducted on data from computed tomographic angiography BBA have been clipped in Department...
Although the clinical and biological importance of calcification is well recognized for extracerebral vasculature, its role in cerebral vascular disease, particularly, intracranial aneurysms (IAs), remains poorly understood. Extracerebrally, 2 distinct mechanisms drive calcification, a nonatherosclerotic, rapid mineralization media slower, inflammation driven, atherosclerotic mechanism intima. This study aims to determine prevalence, distribution, type (atherosclerotic, nonatherosclerotic)...
Background Varying degrees of co‐occurrence intracranial aneurysms ( IA ) and aortic AA have been reported. We sought to compare the risk for in fusiform fIA saccular sIA disease evaluate possible genetic connection between s. Additionally, characteristics patients were compared. Methods Results The Kuopio Intracranial Aneurysm Database includes all 4253 125 from its Eastern Finnish catchment population, 13 009 matched population controls 18 455 first‐degree relatives identified, national...