A5009880637- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Atrial Fibrillation Management and Outcomes
- Thermal Regulation in Medicine
- Peripheral Artery Disease Management
- Retinal and Optic Conditions
- COVID-19 and healthcare impacts
- Cardiac Arrest and Resuscitation
- Blood Pressure and Hypertension Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Malaria Research and Control
- Protease and Inhibitor Mechanisms
- Hospital Admissions and Outcomes
- Epilepsy research and treatment
- Nuclear Engineering Thermal-Hydraulics
- Polyomavirus and related diseases
Universitätsklinikum Würzburg
2024-2025
Heidelberg University
2015-2024
University Hospital Heidelberg
2015-2024
University of Zurich
2020-2023
Helsinki University Hospital
2016-2023
Leipzig University
2023
University of Lausanne
2023
University Hospital of Bern
2023
University of Helsinki
2020-2023
Prevention Institute
2020
BackgroundWhether the large effect size of endovascular thrombectomy (EVT) for stroke due to large-vessel occlusion applies medium-vessel is unclear.MethodsIn a multicenter, prospective, randomized, open-label trial with blinded outcome evaluation, we assigned patients acute ischemic who presented within 12 hours from time that they were last known be well and had favorable baseline noninvasive brain imaging receive EVT plus usual care or alone. The primary was modified Rankin scale score...
To investigate the relationship between severe bleeding complications and outcome after mechanical thrombectomy with or without glycoprotein-IIb/IIIa inhibitor tirofiban treatment.The study included prospectively collected data of consecutive patients acute ischemic stroke in whom was perfomed years 2006 to 2011.Of 162 patients, 128 had anterior circulation stroke, 34 posterior stroke. Additional treatment given 30 20 Treatment did not influence recanalization rates. Fatal intracerebral...
<h3>BACKGROUND AND PURPOSE:</h3> In past years, thrombectomy has become a widely used procedure in interventional neuroradiology for the treatment of acute intracranial occlusions. However, 10–20% patients, there are additional occlusions or stenotic lesions ipsilateral cervical internal carotid artery. The purpose this study was to evaluate feasibility emergency artery stent placement combination with and clinical outcome treated patients. <h3>MATERIALS METHODS:</h3> We analyzed...
<h3>Objective</h3> First, to determine the sensitivity and specificity of six stroke recognition scores in a single cohort improve interscore comparability. Second, test four severity repurposed recognise parallel. <h3>Methods</h3> Of 9154 emergency runs, 689 consecutive cases preclinically 'suspected central nervous system disorder' admitted room (ER) Heidelberg University Hospital were included validation cohort. Using data abstracted from neurological ER medical reports, retrospective...
<h3>BACKGROUND AND PURPOSE:</h3> Basilar artery occlusion remains one of the most devastating subtypes ischemic stroke. The prognosis is poor if early recanalization not achieved. purpose this study was to evaluate safety and technical feasibility self-expanding retrievable stents in endovascular treatment acute basilar occlusion. <h3>MATERIALS METHODS:</h3> Twenty-four patients with were treated Solitaire FR or Revive SE devices between December 2009 May 2012. Additional included...
Background and Purpose— We compared outcome complications in patients with stroke treated intravenous thrombolysis (IVT) who could not live alone without help of another person before (dependent patients) versus independent ones. Methods— In a multicenter IVT-register–based cohort study, we previously dependent (prestroke modified Rankin Scale score, 3–5) 0–2) patients. Outcome measures were poor 3-month (not reaching at least prestroke [dependent patients]; score 3–6 [independent...
<i>Background:</i> Atrial fibrillation (AF) is a frequent cause of stroke, but detecting paroxysmal AF (pAF) poses challenge. We investigated whether continuous bedside ECG monitoring in stroke unit detects pAF more sensitively than 24-hour Holter ECG, and tested examining RR interval dynamics on short-term recordings using an automated screening algorithm (ASA) for detection useful tool to predict the risk outside periods manifest AF. <i>Methods:</i> Patients >60...
Women have a worse outcome after stroke compared with men, although in intravenous thrombolysis (IVT)-treated patients, women seem to benefit more. Besides sex differences, age has also possible effect on functional outcome. The interaction of the IVT-treated patients relation remains complex. purpose this study was compare IVT between and men regard large multicenter European cohort reflecting daily clinical practice acute care.Data were obtained from registries 12 tertiary hospitals....
Objective To develop an NIH Stroke Scale (NIHSS)-compatible, all-in-one scale for rapid and comprehensive prehospital stroke assessment including recognition, severity grading progression monitoring as well prediction of large vessel occlusion (LVO). Methods Emergency medical services (EMS) personnel physicians (n=326) rated each item the NIHSS regarding suitability use; best items were included. recognition was evaluated retrospectively in 689 consecutive patients with acute or mimics, LVO...
To evaluate whether pretreatment with metformin (MET) is associated less stroke severity and better outcome after IV thrombolysis (IVT), we analyzed a cohort of 1,919 patients type 2 diabetes mellitus in multicenter exploratory analysis.Data from ischemic treated IVT were collected within the European Thrombolysis Ischemic Stroke Patients (TRISP) collaboration. We applied propensity score matching (PSM) to obtain balanced baseline characteristics without MET.Of who underwent IVT, 757 (39%)...
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Matrix metalloproteinases (MMPs) are implied in blood-brain barrier degradation and haemorrhagic transformation following ischaemic stroke, but their local relevance the hyperacute disease phase is unknown. We aimed to examine ultra-early MMP-9 MMP-2 release into collateral blood vessels, assess its prognostic value before therapeutic recanalisation by endovascular thrombectomy (EVT).
<h3>Objective</h3> To study the effect of platelet count (PC) on bleeding risk and outcome in stroke patients treated with IV thrombolysis (IVT) to explore whether withholding IVT PC < 100 × 10<sup>9</sup>/L is supported. <h3>Methods</h3> In this prospective multicenter, register–based study, we compared symptomatic intracranial hemorrhage (sICH; Second European-Australasian Acute Stroke Study [ECASS II] criteria), poor (modified Rankin Scale score 3–6), mortality at 3 months. was used as...
Implementing endovascular stroke care often impedes neurologic assessment in patients who need sedation or general anesthesia. Cerebral near-infrared spectroscopy (NIRS) may help physicians monitor cerebral tissue viability, but data hyperacute receiving treatment are sparse. In this observational study, the NIRS index regional oxygen saturation (rSO 2 ) was measured noninvasively before, during, and after therapy via bilateral forehead optodes. During study period, 63 were monitored with...
Significance and management of blood pressure (BP) changes in acute stroke care are unclear. Here, we aimed to investigate the impact 24-hour BP variability (BPV) on outcome patients with ischemic treated intravenous thrombolysis.From Safe Implementation Treatment Stroke International Thrombolysis registry, 28 976 documented pre-treatment systolic at 2 24 hours were analyzed. The primary measure was successive variability. Data preprocessed using coarsened exact matching. We assessed early...
Therapeutic hypothermia improves clinical outcome after cardiac arrest and appears beneficial in other cerebrovascular diseases. We conducted this study to investigate the relationship between surface head/neck cooling brain temperature.Prospective observational enrolling consecutive patients with severe ischemic or hemorrhagic stroke undergoing intracranial pressure (ICP) temperature monitoring. Arterial pressure, ICP, cerebral perfusion heart rate, brain, tympanic, bladder were...
It is not established whether sex influences outcome and safety following intravenous thrombolysis (IVT) in acute stroke. As a significant imbalance exists between the baseline conditions of women men, regression analysis alone may be subject to bias. Here we aimed overcome this methodical shortcoming by balancing both groups using coarsened exact matching (CEM) before evaluating outcome.From our local prospective stroke database analyzed consecutive patients who suffered anterior...
Background and purpose Thrombus length has been reported as an important predictor of successful recanalization by intravenous thrombolysis but its influence on bridging not investigated yet. The effect thrombus rates evaluated catheter angiography early after was analyzed. Methods Ninety‐six consecutive patients with acute cerebral artery occlusion were included. Occlusion site initial computed tomography or magnetic resonance related to the series angiography. Results Eleven 96 (11.5%)...
Background and Purpose— We hypothesized that any sex-related difference in outcome poststroke is explained by other prognostic factors the response to intravenous recombinant tissue-type plasminogen activator (r-tPA) equal males females after adjustment for such factors. Methods— accessed an independent collection of randomized clinical trials—the VISTA (Virtual International Stroke Trials Archive). Data were preprocessed selecting complete cases (n=8028) matching (coarsened exact matching,...
Background: Retinal artery occlusion (RAO) may lead to irreversible blindness. For acute RAO, intravenous thrombolysis (IVT) can be considered as treatment. However, due the rarity of data about IVT safety and effectiveness is limited. Methods: From multicenter database ThRombolysis for Ischemic Stroke Patients (TRISP), we retrospectively analyzed visual acuity (VA) at baseline within 3 months in non-IVT treated RAO patients. Primary outcome was difference VA between follow up (∆VA)....
Seizure at onset (SaO) has been considered a relative contraindication for intravenous thrombolysis (IVT) in patients with acute ischemic stroke, although this appraisal is not evidence based. Here, we investigated the prognostic significance of SaO treated IVT suspected stroke.In multicenter, IVT-registry-based study assessed association between and symptomatic intracranial hemorrhage (sICH, European Cooperative Acute Stroke Study II definition), 3-month mortality, functional outcome on...
Induction methods for therapeutic cooling are under investigated. We compared the effectiveness and safety of cold infusions (CI) nasopharyngeal (NPC) induction in stroke patients.A prospective, open-label, randomised (1:1), single-centre pilot trial with partially blinded endpoint assessment was conducted at neurointensive care unit Heidelberg University. Intubated patients an indication intracranial pressure (ICP)/temperature brain probe were randomly assigned to CI (4°C, 2L 4L/h) or NPC...