A5032309705- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Biosensors and Analytical Detection
- Cerebrovascular and Carotid Artery Diseases
- Advanced biosensing and bioanalysis techniques
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Quantum Dots Synthesis And Properties
- Vascular Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Advanced Biosensing Techniques and Applications
- Dementia and Cognitive Impairment Research
- Central Venous Catheters and Hemodialysis
- Moyamoya disease diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Spine and Intervertebral Disc Pathology
- Vascular Malformations and Hemangiomas
- Fetal and Pediatric Neurological Disorders
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Cerebral Venous Sinus Thrombosis
- Aortic aneurysm repair treatments
- Trigeminal Neuralgia and Treatments
- Vascular Anomalies and Treatments
- SARS-CoV-2 detection and testing
McGill University Health Centre
2021-2025
Montreal Neurological Institute and Hospital
2022-2025
McGill University
2024-2025
Université de Montréal
2021
University Health Network
2006-2021
University of Toronto
2006-2021
Toronto Western Hospital
2018-2021
University of Utah
2018
Hospital for Sick Children
2018
St. Michael's Hospital
2018
Abstract The marriage of nanomaterials with biology has produced a new generation technologies that can profoundly impact biological and biomedical research. Quantum dots (Qdots) are an archetype for this hybrid research area have gained popularity interest from diverse communities because their unique tunable optical properties. In Review, we will describe history development, electronic properties, applications in medicine. A critical evaluation barriers impacting current Qdot be discussed...
BackgroundWhether the large effect size of endovascular thrombectomy (EVT) for stroke due to large-vessel occlusion applies medium-vessel is unclear.MethodsIn a multicenter, prospective, randomized, open-label trial with blinded outcome evaluation, we assigned patients acute ischemic who presented within 12 hours from time that they were last known be well and had favorable baseline noninvasive brain imaging receive EVT plus usual care or alone. The primary was modified Rankin scale score...
Through the convergence of nano- and microtechnologies (quantum dots microfluidics), we have created a diagnostic system capable multiplexed, high-throughput analysis infectious agents in human serum samples. We demonstrate, as proof-of-concept, ability to detect biomarkers most globally prevalent blood-borne diseases (i.e., hepatitis B, C, HIV) with low sample volume (<100 μL), rapidity (<1 h), 50 times greater sensitivity than that currently available FDA-approved methods. further show...
Barcoding made easy: Quantum-dot-based barcodes were synthesized using a new concentration-controlled flow-focusing process. This one-step method yields robust that outperform current technologies and can be used in multiplexed detection of protein genetic markers. Since their creation 1949 by Woodland Silver for grocery warehouse inventory,1 the broad application utility has continuously expanded. Today, response to demand high-throughput elucidation biomolecular mechanisms advancing...
We developed and validated a novel method for quantifying protein expression of cancer tumors in an accurate, sensitive, high throughput format. This technique integrates quantum dots, tissue microarray, optical spectroscopy, algorithm design analysis tumor biopsies. The integration this the clinic bears potential impact improving diagnosis treatment cancer.
<h3>BACKGROUND AND PURPOSE:</h3> Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome is a rare mitochondrial disorder affecting children young adults. Stroke-like are often associated acute cortical lesions in the posterior cerebral cortex classically described as asymmetric transient. In this study we assessed anatomic distribution of lesions, incidence symmetry, temporal evolution lesions. <h3>MATERIALS METHODS:</h3> This was retrospective cohort...
Plasma phosphorylated tau biomarkers open unprecedented opportunities for identifying carriers of Alzheimer's disease pathophysiology in early stages using minimally invasive techniques. p-tau are believed to reflect phosphorylation and secretion. However, it remains unclear what extent the magnitude plasma abnormalities reflects neuronal network disturbance form cognitive impairment. To address this question, we included 103 cognitively unimpaired elderly 40 impaired, amyloid-β positive...
Primary ciliary dyskinesia (PCD) is a genetic disorder causing motile dysfunction primarily affecting the respiratory and reproductive systems. However, impact of PCD on central nervous system remains poorly understood. Rodent models exhibit marked hydrocephalus leading to early animal mortality, however, most humans with do not develop for unknown reasons. We hypothesized that patients sub-clinical ventriculomegaly related ependymal dysfunction. demonstrated highly specific expression...
Abstract Background Impaired kidney function has a potential confounding effect on blood biomarker levels, including biomarkers for Alzheimer’s disease (AD). Given the imminent use of certain in routine diagnostic work-up patients with suspected AD, knowledge impact comorbidities utility is important. We aimed to evaluate association between function, assessed through estimated glomerular filtration rate (eGFR) calculated from plasma creatinine and AD biomarkers, as well their influence over...
Abstract Recently, conceptual systems for the in vivo staging of Alzheimer’s disease (AD) using fluid biomarkers have been suggested. Thus, it is important to assess whether available can successfully stage AD into clinically and biologically relevant categories. In TRIAD cohort, we explored p-tau217, p-tau205 NTA-tau (biomarkers early, intermediate late pathology, respectively) potential biofluid-based cerebrospinal (CSF; n = 219) plasma ( 150), compared them a paired CSF subset 76). Our...
Abstract Background Amyloid-β imaging through positron emission tomography (PET) has significantly transformed Alzheimer’s disease (AD) research. [ 11 C]PiB been widely used for β-amyloid plaques due to its high affinity and selectivity amyloid deposits. 18 F]AZD4694 is a more recently developed amyloid-PET agent, which structurally resembles PiB less non-specific binding in the white matter than other F-labeled compounds. The purpose of this study compare vitro properties radiotracers...
Signal processing methods and constraints for discerning the fluorescence signals of QD-barcodes are explored. their corresponding spectra (see figure) require signal algorithms in order to be uniquely identified. Using these algorithms, we determined number available barcodes use biological detection. We also studied impact chemical such as buffer pH level on barcode read-out design.
Objective To describe the results in patients treated with Surpass Evolve (SE) device, new generation of flow diverters. Methods Twenty-five consecutive (20 women, average age 58 years), anterior or posterior circulation aneurysms SEs two early-user centers, were included. Device properties and related technical properties, imaging clinical follow-up data, intraprocedural, early (<30 days) delayed (>30 neurological complications, further divided into minor (silent/non-permanent) major...
Quantenpunkt-Strichcodes wurden durch einen neuen konzentrationsgesteuerten Flussprozess in einer Stufe hergestellt. Die robusten Strichcodes übertreffen nach üblichen Verfahren erzeugte und bieten sich für den Parallelnachweis von Markierungen Proteinen Genen an.
Hereditary hemorrhagic telangiectasia (HHT) is generally considered a disorder of endothelial dysfunction, characterized by the development multiple systemic arteriovenous malformations (AVMs), including within brain. However, there have recently been number reports correlating HHT with cortical development, which polymicrogyria most common type. Here we present 7 new cases demonstrating in HHT, 6 demonstrate brain AVM (bAVM) close spatial proximity, aim providing origin for association....