A5081473486- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Dementia and Cognitive Impairment Research
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Diet and metabolism studies
- Coffee research and impacts
- Medical Imaging Techniques and Applications
- Eating Disorders and Behaviors
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Neonatal and fetal brain pathology
- Metabolomics and Mass Spectrometry Studies
- Advanced MRI Techniques and Applications
- Adenosine and Purinergic Signaling
- Intensive Care Unit Cognitive Disorders
- Health, Environment, Cognitive Aging
- Computational Drug Discovery Methods
- Advanced Neuroimaging Techniques and Applications
- Immune cells in cancer
- Birth, Development, and Health
- Biochemical Analysis and Sensing Techniques
- Cholinesterase and Neurodegenerative Diseases
University of Pittsburgh
2024-2025
Universidade Federal do Rio Grande do Sul
2014-2024
Faculdade de Ciências Médicas de Minas Gerais
2024
Universidade Federal do Rio Grande
2022
Pontifícia Universidade Católica do Rio Grande do Sul
2021
Université de Poitiers
2021
McGill University
2021
Washington University in St. Louis
2020
Hope Center for Neurological Disorders
2017
Hospital de Clínicas de Porto Alegre
2016
Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer's disease (AD) patients. Here, we studied associations cerebrospinal fluid (CSF) glial fibrillary acidic protein (GFAP) and chitinase-3-like 1 (YKL-40) levels with amyloid-β (Aβ) tau pathologies. We assessed 121 individuals across aging AD clinical spectrum positron emission tomography (PET) imaging for Aβ ([
Intracerebroventricular (icv) streptozotocin (STZ) administration induces pathological and behavioral alterations similar to those observed in Alzheimer's disease (AD) is thus considered an experimental model of sporadic AD. Since caffeine (an ad
Sleep disturbances are prevalent in human tauopathies yet despite the importance of sleep, little is known about its relationship with tau pathology. Here, we investigate this interaction by analyzing sleep and pathology throughout tauopathy disease progression P301S transgenic mice.P301S wild-type mice were analyzed electroencephalography (EEG)/electromyography at 3, 6, 9, 11 months age for sleep/wake time, EEG power, homeostatic response. Cortical volume was also assessed anti-phospho-tau...
Blood-based biomarkers (BBMs) have emerged as promising tools to enhance Alzheimer's disease (AD) diagnosis. Despite two-thirds of dementia cases occurring in the Global South, research on BBMs has predominantly focused populations from North. This geographical disparity hinders our understanding BBM performance diverse populations. To address this, we evaluated diagnostic properties AD a real-world memory clinic Brazil, one largest countries South. We measured blood and cerebrospinal fluid...
Abstract Background Amyloid-β imaging through positron emission tomography (PET) has significantly transformed Alzheimer’s disease (AD) research. [ 11 C]PiB been widely used for β-amyloid plaques due to its high affinity and selectivity amyloid deposits. 18 F]AZD4694 is a more recently developed amyloid-PET agent, which structurally resembles PiB less non-specific binding in the white matter than other F-labeled compounds. The purpose of this study compare vitro properties radiotracers...
Our objective was to evaluate the in vitro binding properties of [
Caffeine is the psychostimulant most consumed worldwide. However, little known about its effects during fetal brain development. In this study, adult female Wistar rats received caffeine in drinking water (0.1, 0.3 and 1.0 g/L) active cycle weekdays, two weeks before mating throughout pregnancy. Cerebral cortex hippocampus from embryonic stages 18 or 20 (E18 E20, respectively) were collected for immunodetection of following synaptic proteins: brain-derived neurotrophic factor (BDNF), TrkB...
Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances understanding MDD and its treatment, profound innovation is needed develop fast-onset antidepressants with higher effectiveness. When acutely administered, endogenous nucleoside guanosine (GUO) shows antidepressant-like effects several mouse models, including olfactory bulbectomy (OBX) rodent model. OBX advocated possess translational value be suitable assess time course...
Sepsis is characterized by a severe and disseminated inflammation. In the central nervous system, sepsis promotes synaptic dysfunction permanent cognitive impairment. Besides sepsis-induced neuronal dysfunction, glial cell response has been gaining considerable attention with microglial activation as key player. By contrast, astrocytes’ role during acute still underexplored. Astrocytes are specialized immunocompetent cells involved in brain surveillance. this context, potential communication...
Few studies have addressed the effects of caffeine in puberty and/or adolescence a sex dependent manner. Considering that intake has increased this population, we investigated behavioral and synaptic proteins changes pubescent male female rats after maternal consumption caffeine. Adult Wistar started to receive water or (0.1 0.3g/L drinking water; low moderate dose, respectively) during active cycle at weekdays, two weeks before mating. The treatment lasted up weaning offspring received...
Abstract Introduction In Alzheimer’s disease clinical research, glial fibrillary acidic protein (GFAP) released into the cerebrospinal fluid and blood is widely measured perceived as a biomarker of reactive astrogliosis. However, it was demonstrated that GFAP levels differ in individuals presenting with amyloid-β (Aβ) or tau pathology. The molecular underpinnings behind this specificity are unexplored. Here we investigated transcriptomic associations GFAP-positive astrocytes Aβ pathologies...
OPINION article Front. Aging Neurosci., 29 November 2016Sec. Alzheimer's Disease and Related Dementias Volume 8 - 2016 | https://doi.org/10.3389/fnagi.2016.00280
O artigo apresenta uma avaliação do estado de conservação treze barragens rejeitos mineração no Pará, construídas em aterro compactado, baixa a média altura, visando contribuir com recomendações procedimentos preventivos e corretivos das anomalias que mais incidiram nas fichas inspeção verificadas documento consulta, os Relatórios vistorias da SEMAS- -PA. A metodologia seguiu as etapas: a) Solicitação à SEMAS-PA dos barragem 2023 2024; b) Levantamento dados técnicos identificação registradas...