A5065343525- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
- Coffee research and impacts
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Organoselenium and organotellurium chemistry
- Eating Disorders and Behaviors
- Selenium in Biological Systems
- Sulfur Compounds in Biology
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Biochemical Analysis and Sensing Techniques
- Memory and Neural Mechanisms
- Suicide and Self-Harm Studies
- Zebrafish Biomedical Research Applications
- Molecular Sensors and Ion Detection
- Homicide, Infanticide, and Child Abuse
- Bipolar Disorder and Treatment
- Heavy Metal Exposure and Toxicity
- Biochemical effects in animals
- Attachment and Relationship Dynamics
- Coenzyme Q10 studies and effects
Universidade Católica de Pelotas
2017-2024
University of Coimbra
2015-2024
Universidade Federal do Rio Grande do Sul
2008-2017
Universidade Federal de Santa Maria
2006-2010
Significance Epidemiological studies show that individuals exposed to repeated stress, a major trigger of depression, increase their caffeine intake, which correlates inversely with the incidence depression. However, mechanism underlying this protective effect is unknown. We used an animal model chronic unpredictable stress (CUS) prevents maladaptive changes caused by CUS in manner mimicked selective blockade adenosine A 2A receptors (A R). enhanced R synapses, and elimination neuronal...
Environmental enrichment (EE) is an experimental model for studying neuroplasticity. EE used to investigate behavioral modifications associated with gene-environmental interaction. The object recognition task (ORT) evaluates animals' ability learn about their environment, which depends on innate instinct. By using young CF1 mice, the present study evaluated effect of 8 weeks ORT. Our results indicate that decreased time animals spent exploring familiar and unfamiliar objects total both...
Postpartum depression (PPD) affects a high number of women, often the first manifestation mood disorder that will occur later in life, bringing serious consequences for patient and her offspring. Depression today is leading cause disability worldwide. The aim this study was to evaluate effectiveness preventive cognitive behavioral therapy (CBT) PPD.
Methylphenidate (MPH) is the preferred treatment used for attention-deficit/hyperactivity disorder (ADHD). Recently, misuse MPH due to its apparent cognitive enhancer properties has been reported. Adenosine a neuromodulator known exert influence on dopaminergic neurotransmission, which main pharmacological target of MPH. We have reported that an overdosage up-regulates adenosine A(1) receptors in frontal cortex, but this receptor was not involved anxiolytic effects. In study, role...
Physical exercise protocols have varied widely across studies raising the question of whether there is an optimal intensity, duration and frequency that would produce maximal benefits in attenuating symptoms related to anxiety disorders. Although physical causes modifications neurotransmission systems, involvement neuromodulators such as adenosine has not been investigated after chronic training. Anxiety-related behavior was assessed elevated plus-maze adult middle-aged rats submitted 8...
This study was designed to examine if ebselen, an organoselenium compound with antioxidant and glutathione peroxidase-mimetic properties, attenuates testicular injury caused by intraperitoneal administration of CdCl(2). A number toxicological parameters were evaluated in the testes mice, such as delta-aminolevulinic acid dehydratase (delta-ALA-D) activity, lipid peroxidation, ascorbic levels alanine aminotransferase (ALT) aspartate (AST) activities. Ebselen attenuated peroxidation altered...
Diphenyl diselenide (PhSe)2 is a selenium organic compound that has been described to inhibit glutamate binding at synaptic membranes and uptake into cortical slices, but there are no studies about its effects on transporters related proteins. Hippocampal slices from rats treated acutely with (1, 10, 100 mg/kg, oral route) were evaluated uptake, redox state, the immunocontent of glial (glutamate/aspartate transporter [GLAST] type I [GLT1]), neuronal (excitatory amino acid carrier 1 [EAAC1]),...
The protective effect of diphenyl diselenide, (PhSe)(2), on oxidative stress induced by cigarette smoke exposure in brains rat pups was evaluated. Animals were exposed to passive (15 min/day) two different experimental protocols: P1 (1, 2, and 3 cigarettes) P2 (4, 5, 6 for weeks. Before each period exposure, animals received an oral administration (PhSe)(2) (0.5 mg/kg). A number toxicological parameters the brain examined, such as lipid peroxidation, delta-aminolevulinate dehydratase...
Background Burnout, a type of long-lasting work-related stress, is highly prevalent among health professionals. It includes dimensions emotional exhaustion, depersonalization and low professional achievement. Emotional intelligence the ability to accurately perceive, evaluate, express emotions, perceive and/or produce feelings that facilitate thought, understand emotion acquire knowledge, control emotions in order promote intellectual growth. Among extensive literature on burnout, no studies...
ABSTRACT Cadmium (Cd) is a pollutant that harmful to human and animals. The liver target for Cd accumulation it can disrupt Zn homeostasis. Here we examined the interaction of determine how these two metals could affect δ ‐aminolevulinate‐dehydratase ( ‐ALA‐D) metallothionein (MT), potential molecular endpoints hepatotoxicity. exposure (0.25 1 mg kg body weight, i.p., 10 days) caused marked increase in hepatic deposition, which was not modified by treatment with (2 , i.p.). dose‐dependent...
Few studies have addressed the effects of caffeine in puberty and/or adolescence a sex dependent manner. Considering that intake has increased this population, we investigated behavioral and synaptic proteins changes pubescent male female rats after maternal consumption caffeine. Adult Wistar started to receive water or (0.1 0.3g/L drinking water; low moderate dose, respectively) during active cycle at weekdays, two weeks before mating. The treatment lasted up weaning offspring received...
Background Suicide risk is prominent among the problems affecting populations, mainly due to broad family, psychosocial and economic impact. Most individuals at suicidal have some mental disorder. There considerable evidence that psychiatric disorders are accompanied by activation of neuro-immune neuro-oxidative pathways. The aim study evaluate serum levels oxidative stress biomarkers in women suicide after 18 months postpartum. Methods This a case-control study, nested within cohort study....