A5062748635- Zebrafish Biomedical Research Applications
- Physiological and biochemical adaptations
- Fish Ecology and Management Studies
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Aldose Reductase and Taurine
- Aquaculture Nutrition and Growth
- Paraquat toxicity studies and treatments
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Environmental Toxicology and Ecotoxicology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Animal Behavior and Reproduction
- Selenium in Biological Systems
- Neuroscience and Neuropharmacology Research
- Biological and pharmacological studies of plants
- Aquaculture disease management and microbiota
- Agricultural and Food Sciences
- Pesticide Exposure and Toxicity
- Hydrogen's biological and therapeutic effects
- Pain Mechanisms and Treatments
- Insect and Pesticide Research
Universidade de São Paulo
2023
Universidade Federal de Santa Maria
2015-2021
The zebrafish (Danio rerio) is used as an emergent model organism to investigate the behavioral and physiological responses stress. anxiolytic-like effects of taurine in support existence different mechanisms action, which can play a role preventing stress-related disorders (i.e., modulation GABAA, strychnine-sensitive glycine, NMDA receptors, well antioxidant properties). Herein, we whether modulates some biochemical acutely submitted chemical mechanical stressors. We pretreated for 1 h...
Social behaviors are key components that play adaptive roles in various species, including humans. The zebrafish (Danio rerio) is a social species and the shoaling behavior can be pharmacologically manipulated either by anxiogenic or anxiolytic substances, providing translatable data neuropsychiatric research. Here, we aimed to characterize under different pharmacological manipulations three-dimensional (3D) perspective using spatial coordinates of fish positions. Temporal reconstructions...
Ketamine is a non-competitive glutamatergic antagonist that induces analgesia and anesthesia. Although ketamine displays anxiolytic antidepressant properties, it may induce pro-psychosis hallucinogen effects, as well stereotypic behaviors following acute administration at sub-anesthetic doses. Since heightened aggression maladaptive comorbid with various neuropsychiatric disorders, we aimed to investigate whether modulates aggressive behavior in adult zebrafish. Fish were acutely exposed 2,...
Aversive conditions elicit anxiety responses that prepare the organism to an eventual threat. Nonetheless, prolonged is a pathological condition associated with various neuropsychiatric disorders. Here, we evaluated whether conspecific alarm substance (CAS), chemical cue elicits aversion, influences anxiety-like behaviors and modulates brain oxidative stress-related parameters in wild-type (WT) leopard (leo) zebrafish following repeated exposure protocol. CAS was performed for 5 min, once...
Azadirachtin (Aza) is a promisor biopesticide used in organic production and aquaculture. Although this compound apparently safe, there evidence that it may have deleterious effects on fish. Behavioral hematological tests are grouped into set of parameters predict potential toxicity chemical compounds. Here, we investigate the Aza, commercial formulation Neenmax™ , carp (Cyprinus carpio) by defining LC50 (96 h), testing behavioral parameters. In our study, was estimated at 80 μL/L. We...
: The ability of the nervous system to detect a wide range noxious stimuli is crucial avoid life-threatening injury and trigger protective behavioral physiological responses. Pain represents complex phenomenon, including nociception associated with cognitive emotional processing. Animal experimental models have been developed understand mechanisms involved in pain response, as well discover novel pharmacological non-pharmacological anti-pain therapies. Due genetic tractability, similar...
Epilepsy is characterized by abnormal and recurrent hyperexcitability in brain cells. Various comorbidities are associated with epilepsy, including irritability aggressive behavior. Aggression a negative effect observed epileptic patients that may be harmful to other individuals, impairing social relations. Thus, developing novel experimental models assess behavioral phenotypes comorbid neurological disorders of great interest. Here, we investigate whether pentylenetetrazole (PTZ) increases...