A5074513956- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Long-Term Effects of COVID-19
- S100 Proteins and Annexins
- Medical Imaging Techniques and Applications
- Adenosine and Purinergic Signaling
- Bioinformatics and Genomic Networks
- Tryptophan and brain disorders
- Epilepsy research and treatment
- Sirtuins and Resveratrol in Medicine
- Advanced MRI Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Amino Acid Enzymes and Metabolism
- Biochemical effects in animals
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Neurological Disease Mechanisms and Treatments
- Science and Education Research
- Functional Brain Connectivity Studies
- Moyamoya disease diagnosis and treatment
- Folate and B Vitamins Research
- Immune cells in cancer
- Thermal Regulation in Medicine
Universidade Federal do Rio Grande do Sul
2016-2025
Instituto do Cérebro
2023-2024
Pontifícia Universidade Católica do Rio Grande do Sul
2021-2023
Universidade Federal do Rio Grande
2022
Université de Poitiers
2021
McGill University
2021
Universidade Católica de Pelotas
2010
Astrocytes are responsible for modulating neurotransmitter systems and synaptic information processing, ionic homeostasis, energy metabolism, maintenance of the blood-brain barrier, antioxidant inflammatory responses. Our group recently published a culture model cortical astrocytes obtained from adult Wistar rats. In this study, we established an in vitro hippocampal astrocyte cultures (90 days old) aged (180 Resveratrol, polyphenol found grapes red wine, exhibits antioxidant,...
Astrocytes, a major class of glial cells, regulate neurotransmitter systems, synaptic processing, ion homeostasis, antioxidant defenses and energy metabolism. Astrocyte cultures derived from rodent brains have been extensively used to characterize astrocytes' biochemical, pharmacological morphological properties. The aims this study were develop protocol for routine preparation primary astrocyte culture the adult (90 days old) Wistar rats. For we enzymatic digestion (trypsin papain)...
Abstract Guanosine, a guanine‐based purine, is an extracellular signaling molecule that released from astrocytes and shows neuroprotective effects in several vivo vitro studies. Our group recently showed guanosine presents antioxidant properties C6 astroglial cells. The heme oxygenase 1 pathway associated with protection against oxidative stress. Azide, inhibitor of the respiratory chain, frequently used experimental models to induce nitrosative Thus, goal this study was investigate effect...
Background and Purpose Stroke is a devastating disease. Both excitotoxicity oxidative stress play important roles in ischemic brain injury, along with harmful impacts on cerebral tissue. As guanosine plays an neuroprotective role the central nervous system, purpose of this study was to evaluate effects putative events following onset permanent focal ischemia. Methods Permanent ischemia induced rats by thermocoagulation. Guanosine administered immediately, 1 h, 3 h 6 after surgery. Behavioral...
Blood-based biomarkers (BBMs) have emerged as promising tools to enhance Alzheimer's disease (AD) diagnosis. Despite two-thirds of dementia cases occurring in the Global South, research on BBMs has predominantly focused populations from North. This geographical disparity hinders our understanding BBM performance diverse populations. To address this, we evaluated diagnostic properties AD a real-world memory clinic Brazil, one largest countries South. We measured blood and cerebrospinal fluid...
Abstract Background Amyloid-β imaging through positron emission tomography (PET) has significantly transformed Alzheimer’s disease (AD) research. [ 11 C]PiB been widely used for β-amyloid plaques due to its high affinity and selectivity amyloid deposits. 18 F]AZD4694 is a more recently developed amyloid-PET agent, which structurally resembles PiB less non-specific binding in the white matter than other F-labeled compounds. The purpose of this study compare vitro properties radiotracers...
Essential omega-3 polyunsaturated fatty acids (omega3) are crucial to brain development and function, being relevant for behavioral performance. In the present study we examined influence of dietary omega3 in glutamatergic system on behavior parameters rats. Female rats received isocaloric diets, either with (omega3 group) or a deficient diet (D group). ontogeny experiments their litters, hippocampal immunocontent ionotropic NMDA AMPA receptors subunits (NR2 A\B GluR1, respectively) alpha...
Astrocytes, the most versatile cells of central nervous system, play an important role in regulation neurotransmitter homeostasis, energy metabolism, antioxidant defenses and anti-inflammatory response. Recently, our group characterized cortical astrocyte cultures from adult Wistar rats. In line with that work, we studied glial function using experimental vitro model aging astrocytes (30 days after reaching confluence) newborn (NB), (AD) aged (AG) We evaluated metabolic parameters, such as...
Our objective was to evaluate the in vitro binding properties of [