Jean-Paul R. Soucy
A5083904440- COVID-19 epidemiological studies
- Antibiotic Use and Resistance
- COVID-19 Digital Contact Tracing
- COVID-19 and Mental Health
- COVID-19 Pandemic Impacts
- Bacterial Identification and Susceptibility Testing
- Health Policy Implementation Science
- Data-Driven Disease Surveillance
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Historical and modern epidemiology studies
- Aging, Elder Care, and Social Issues
- Patient Satisfaction in Healthcare
- Elder Abuse and Neglect
- Public Health Policies and Education
- Tryptophan and brain disorders
- Pharmaceutical Practices and Patient Outcomes
- Human-Animal Interaction Studies
- Influenza Virus Research Studies
- Advanced Neuroimaging Techniques and Applications
- Nosocomial Infections in ICU
Montreal Neurological Institute and Hospital
2021-2025
Public Health Ontario
2020-2024
University of Toronto
2020-2024
3M (United States)
2021-2022
McGill University
2021
Abstract Background Governments have implemented population-wide physical distancing measures to control COVID-19, but metrics evaluating their effectiveness are not readily available. Methods We used a publicly available mobility index from popular transit application evaluate the effect of on infection growth rates and reproductive numbers in 40 jurisdictions between March 23 April 12, 2020. Findings A 10% decrease was associated with 14.6% (exp(β) = 0·854; 95% credible interval: 0·835,...
Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from >1 200 healthy individuals to construct a whole-brain 3-D normative 19 transporters across 9 different neurotransmitter systems. We find that profiles align with structural...
Abstract Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau amyloid-beta pathology. Studying the development prior to symptoms onset may lead early diagnostic biomarkers a better understanding pathophysiology. pathology thought arise from combination protein spreading via neural connections, but how these processes influence atrophy progression phases remains unclear. Individuals family history (FHAD) have an elevated risk...
Abstract Background Amyloid-β imaging through positron emission tomography (PET) has significantly transformed Alzheimer’s disease (AD) research. [ 11 C]PiB been widely used for β-amyloid plaques due to its high affinity and selectivity amyloid deposits. 18 F]AZD4694 is a more recently developed amyloid-PET agent, which structurally resembles PiB less non-specific binding in the white matter than other F-labeled compounds. The purpose of this study compare vitro properties radiotracers...
Tools to advance antimicrobial stewardship in the primary health care setting, where most antimicrobials are prescribed, urgently needed. The aim of this study was evaluate OPEN Stewarship (Online Platform for Expanding aNtibiotic Stewardship), an automated feedback intervention, among a cohort physicians. We performed controlled, interrupted time-series 32 intervention and 725 control participants, consisting physicians from Ontario, Canada Southern Israel, October 2020 December 2021....
Optimal decision-making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation-bias emerges in older adulthood would be associated with lower microstructural integrity coeruleus. Leveraging vivo histological methods from quantitative MRI-magnetic transfer saturation—we provide evidence age is integrity. Critically, we demonstrate bias adulthood, assessed...
Background The rapid global emergence of the COVID-19 pandemic in early 2020 created urgent demand for leading indicators to track spread virus and assess consequences public health measures designed limit transmission. Public transit mobility, which has been shown be responsive previous societal disruptions such as disease outbreaks terrorist attacks, emerged an candidate. Methods We conducted a longitudinal ecological study association between mobility reductions transmission using...
Abstract Parkinson’s disease (PD) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in substantia nigra (SN) locus coeruleus (LC), respectively, resulting motor cognitive impairments. While SN dopamine dysfunction has clear neurophysiological effects, association reduced LC norepinephrine signaling with brain activity PD remains to be established. We used neuromelanin-sensitive T1-weighted MRI (NPD = 58; NHC 27) task-free magnetoencephalography 65) identify...
Introduction Antimicrobial resistance (AMR) impacts the health and well-being of animals, affects animal owners both socially economically, contributes to AMR at human environmental interface. The overuse and/or inappropriate use antibiotics in animals has been identified as one most important drivers development animals. Effective antibiotic stewardship interventions such feedback can be adopted veterinary practices improve prescribing. However, provision dedicated financial technical...
Abstract Prior research has demonstrated the importance of a healthy lifestyle to protect brain health and diminish dementia risk in later life. While multidomain provides an ecological perspective voluntary engagement, its association with is still under-investigated. Therefore, understanding neural mechanisms underlying particularly older adults at for Alzheimer’s disease (AD), gives valuable insights into providing advice intervention those need. The current study included 139 familial AD...
Abstract Background Among non-pharmaceutical interventions, individual movement restrictions have been among the most impactful methods for controlling COVID-19 case growth. While nighttime curfews to control growth implemented in certain regions and cities, few studies examined their impacts on mobility or incidence. In second wave of COVID-19, Canada’s two largest adjacent provinces lockdown with (Quebec) without (Ontario) a curfew, providing natural experiment study association between...
Abstract Background COVID-19 and antimicrobial resistance (AMR) are two intersecting global public health crises. Objective We aim to describe the impact of pandemic on AMR across healthcare settings. Data Source A search was conducted in December 2021 World Health Organization’s Research Database with forward citation searching up June 2022. Study Eligibility Studies evaluating any population were included influencing factors extracted. Methods Pooling done separately for Gram-negative...
Introduction Antimicrobial resistance undermines our ability to treat bacterial infections, leading longer hospital stays, increased morbidity and mortality, a mounting burden the healthcare system. stewardship is increasingly important safeguard efficacy of existing drugs, as few new drugs are in developmental pipeline. While significant progress has been made with respect hospitals, relatively little primary care setting, where majority antimicrobials prescribed. OPEN Stewardship an...
Abstract Background Non-pharmaceutical interventions remain a primary means of suppressing COVID-19 until vaccination coverage is sufficient to achieve herd immunity. We used anonymized smartphone mobility measures in seven Canadian provinces quantify the level needed suppress (mobility threshold ), and difference relative current levels gap ). Methods conducted longitudinal study weekly incidence from March 15, 2020 January 16, 2021, among with 20 cases at least 10 weeks. The outcome was...
Abstract Background In the fall of 2020, government Ontario, Canada adopted a 5-tier, regional framework public health measures for COVID-19 pandemic. During second wave in urban core Greater Toronto Area (Toronto and Peel) were first regions province to enter highest restriction tier (“lockdown”) on November 23, which closed restaurants in-person dining limited non-essential businesses, including shopping malls, curbside pickup. The peripheral (York, Durham, Halton) would not lockdown until...
Abstract Background Mobile phone-derived human mobility data are a proxy for disease transmission risk and have proven useful during the COVID-19 pandemic forecasting cases evaluating interventions. We propose novel metric using to characterize responsiveness rising case rates. Methods examined weekly reported incidence retail recreation from Google Community Mobility Reports 50 U.S. states nine Canadian provinces December 2020 November 2021. For each jurisdiction, we calculated of when were...
For nearly 150 years the University of Toronto has integrated public health into its teaching and research. From early lectures in sanitation (1871) to discovery insulin (1921), Toronto’s rich history is reflected prominence as a global leader research education. Therefore, it fitting for host an academic journal that showcases both high-impact scholarship practice. Founded 2020, Journal Public Health ambitious, yet essential, vision: foster next generation researchers practitioners order...
Epidemic curves are used by decision makers and the public to infer trajectory of COVID-19 pandemic understand appropriateness current response measures. Symptom onset date is commonly cases on epidemic curve in health reports dashboards. However, third-party trackers often plot they were publicly reported authority. These two create very different impressions progression. On April 1, for Ontario, Canada based reporting showed an accelerating epidemic, whereas a proxy variable symptom...