A5072399797- Dementia and Cognitive Impairment Research
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Geriatric Care and Nursing Homes
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Epilepsy research and treatment
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Memory Processes and Influences
- Cognitive Functions and Memory
- Health disparities and outcomes
- Psychosomatic Disorders and Their Treatments
- Intergenerational Family Dynamics and Caregiving
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Migration, Aging, and Tourism Studies
- Traumatic Brain Injury Research
- Neural and Behavioral Psychology Studies
- Frailty in Older Adults
- Diet and metabolism studies
- Obsessive-Compulsive Spectrum Disorders
Johns Hopkins Medicine
2014-2025
Johns Hopkins University
2015-2025
Johns Hopkins Hospital
1994-2022
Alzheimer’s Disease Neuroimaging Initiative
2022
University of Minnesota
2020
Mayo Clinic in Florida
2020
University of North Carolina at Chapel Hill
2020
University of Kentucky
2020
WinnMed
2020
Aarhus University
2019
Abstract The Hopkins Verbal Learning Test (HVLT) is a brief verbal learning and memory test with six alternate forms. HVLT ideal in situations calling for repeated neuropsychological examinations, but it lacks delayed recall trial which essential the assessment of abnormal forgetting. We present revised version includes trial, therefore delays yes/no recognition trial. equivalence forms was examined two separate studies using between-groups within-subjects research designs. In both studies,...
Abstract A new test of verbal learning and memory, the Hopkins Verbal Learning Test, was developed. The consists three trials free-recall a 12-item, semantically categorized list, followed by yes/no recognition. Six parallel forms yielded equivalent results in normals. performance patients with Alzheimer's disease chronic amnesia is described. likely to be useful too impaired for more comprehensive memory assessments where repeated testing necessary.
Up to 25% of adolescent girls in the USA are iron deficient. This double-blind, placebo-controlled clinical trial assessed effects supplementation on cognitive function with non-anaemic deficiency.716 who enrolled at four Baltimore high schools were screened for deficiency (serum ferritin < or = 12 micrograms/L normal haemoglobin). 98 (13.7%) had whom 81 trial. Participants randomly assigned oral ferrous sulphate (650 mg twice daily) placebo 8 weeks. The effect treatment was by...
Summary: Purpose: To determine cumulative incidence and predictors of new‐onset seizures in mild Alzheimer's disease (AD) with a cohort followed prospectively. Limited information is available on the seizures, no reports exist seizure AD patients. Methods: Mild patients were prospectively at 6‐month intervals to estimate unprovoked compare age‐specific risk population norms, identify characteristics baseline (demographics, duration severity AD, physical diagnostic test findings, comorbid...
The present investigation examined the validity of revised Hopkins Verbal Learning Test (HVLT-R). In a principal components analysis with varimax rotation, measures new learning and delayed recall loaded on single factor distinguishable from related to general cognitive function visual memory. HVLT-R also correlated most strongly other tests verbal memory relatively weakly test intelligence. Group comparisons showed that normal controls performed better than age- education-matched patients...
We reviewed the records of 210 patients in Johns Hopkins Alzheimer's Disease Research Center to evaluate role nonsteroidal anti-inflammatory drugs (NSAIDs) on clinical features and progression disease. compared taking NSAIDs or aspirin a daily basis (N = 32) non-NSAID 177) clinical, cognitive, psychiatric measures. The NSAID group had significantly shorter duration illness at study entry. Even after controlling for this difference, performed better Mini-Mental State Examination, Boston...
<b><i>Background:</i></b> Huntington disease (HD) is characterized by striatal atrophy that begins long before the onset of motor symptoms. <b><i>Objective:</i></b> To determine when begins, extent and rate diagnosis symptoms, whether can predict symptom will occur. <b><i>Methods:</i></b> Caudate putamen volumes were measured on MRI scans 19 preclinical subjects with HD gene expansion who very far (9 to 20 years) from estimated onset, serial 17 subjects, six whom diagnosed within 5 years...
<h3>Context</h3> Major depression affects about 25% of the patients who have Alzheimer disease and has serious adverse consequences for caregivers. Results prior antidepressant treatment studies produced contradictory findings not fully assessed benefits reduction. <h3>Objectives</h3> To assess efficacy safety sertraline hydrochloride major in disease, to evaluate effect reduction on activities daily living, cognition, nonmood behavioral disturbance. <h3>Design</h3> Randomized,...
• The nature of the memory and visuospatial defects associated with chronic alcoholism, recovery these functions, were investigated in a large group alcoholic men well-matched nonalcoholic controls. Both young old alcoholics displayed significant impairments on tasks requiring learning novel associations holding information over longer delay intervals. cognitive skills was found to depend length abstinence particular behavioral functions examined. Whereas psychomotor short-term improved...
<h3>Background</h3> Observational studies have shown reduced risk of Alzheimer dementia in users nonsteroidal anti-inflammatory drugs. <h3>Objective</h3> To evaluate the effects naproxen sodium and celecoxib on cognitive function older adults. <h3>Design</h3> Randomized, double-masked chemoprevention trial. <h3>Setting</h3> Six US memory clinics. <h3>Participants</h3> Men women aged 70 years with a family history disease; 2117 2528 enrolled had follow-up assessment. <h3>Interventions</h3>...
The empathy-altruism hypothesis claims that prosocial motivation associated with feeling empathy for a person in need is directed toward the ultimate goal of benefiting person, not some subtle form self-benefit. We explored two new egoistic alternatives to this hypothesis. empathy-specific reward proposes obtaining social or self-rewards (i.e., praise, honor, and pride). punishment avoiding self-punishments censure, guilt, shame). Study 1 provided an initial test Studies 2 through 4 used...
Delusions and hallucinations are common in Alzheimer disease (AD) there conflicting reports regarding their ability to predict cognitive decline, functional institutionalization. According all previous literature, they not associated with mortality.To examine whether the presence of delusions or has predictive value for important outcomes AD.A total 456 patients AD at early stages (mean Folstein Mini-Mental State Examination [MMSE] score 21 30 entry) were recruited followed up semiannually...
Background Epidemiologic evidence suggests that nonsteroidal anti‐inflammatory drugs (NSAIDs) delay onset of Alzheimer's dementia (AD), but randomized trials show no benefit from NSAIDs in patients with symptomatic AD. The Disease Anti‐inflammatory Prevention Trial (ADAPT) 2528 elderly persons to naproxen or celecoxib versus placebo for 2 years (standard deviation = 11 months) before treatments were terminated. During the treatment interval, 32 cases AD revealed increased rates both...
<h3>Background</h3> Transient symptoms in Alzheimer disease (AD) are frequent and include seizures, syncope, episodes of inattention or confusion. The incidence seizures AD predictors which patients with might be more predisposed to them is based primarily on retrospective studies not well established. <h3>Objective</h3> To determine the new-onset unprovoked seizures. <h3>Design</h3> Prospective cohort study. <h3>Setting</h3> Three academic centers. <h3>Patients</h3> Four hundred fifty-three...
Escherichia coli O157:H7 is the leading cause of hemolytic uremic syndrome (HUS). Risk factors for development this complication warrant identification.We enrolled children infected with E. within 1 week onset diarrhea in prospective cohort study. The study was conducted 5 states over 9.5 years . primary and secondary outcomes were HUS (hematocrit <30% smear evidence hemolysis, platelet count <150 × 10(3)/µL, serum creatinine concentration > upper limit normal age) oligoanuric HUS....
Importance National Institute on Aging–Alzheimer’s Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD). Objective To assess the clinical value of these older without cognitive impairment who are at near-term risk developing symptomatic AD. Design, Setting, and Participants This longitudinal cohort study used data from 4 independent population-based cohorts (PREVENT-AD, HABS, AIBL, Knight ADRC)...
<h3>Objective.</h3> —To develop and validate an approach that uses clinical features can be determined in a standard patient visit to estimate the length of time before individual with Alzheimer disease (AD) requires care equivalent nursing home placement or dies. <h3>Design.</h3> —Prospective cohort study 236 patients, followed up semiannually for 7 years. A second validation 105 patients was also followed. <h3>Setting.</h3> —Three AD research centers. <h3>Patients.</h3> —All met National...
Objective To evaluate variables associated with quality of life (QOL) in dementia residents a long-term care facility using recently standardized and validated dementia-specific QOL scale (ADRQL). Method A cross-sectional, case-control design was employed scales to assess dementia-related symptomatology. Thirty-two staff members were interviewed the 120 patients meeting DSM-IV for criteria residing care. Results ADRQL scores higher assisted living than skilled nursing residents. In...
We examined the pattern of cognitive impairment and rate functional decline as a function age at symptom onset in 127 patients with probable Alzheimer9s disease (AD). At baseline, early-onset (before 65) late-onset groups were mildly comparably impaired on modified Mini-Mental State Examination (mMMS) Blessed Dementia Rating Scale-Part 1 (BDRS). Repeated-measures analysis variance revealed significantly more rapid subjects over 2-year follow-up period. Multivariate linear regression analyses...
To report the outcomes of 58 hemispherectomies performed at Johns Hopkins between 1968 and January 1996.Charts were reviewed Medical Institutions by Pediatric Epilepsy Group during years to 1996. Twenty-seven operations done for Rasmussen's syndrome, 24 cortical dysplasias/hemimegalencephalies, 7 Sturge-Weber syndrome or other congenital vascular problems. Seizure control alone did not seem adequately describe procedure. Therefore, a score was constructed that included seizure frequency,...