A5005864631- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Neurotransmitter Receptor Influence on Behavior
- Radiopharmaceutical Chemistry and Applications
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Cardiac Imaging and Diagnostics
- Alzheimer's disease research and treatments
- Nicotinic Acetylcholine Receptors Study
- Epilepsy research and treatment
- Lanthanide and Transition Metal Complexes
- Glioma Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Computational Drug Discovery Methods
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Advanced Radiotherapy Techniques
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Attention Deficit Hyperactivity Disorder
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
Yale University
2016-2025
Laboratoire d’Imagerie Biomédicale
2025
Yale Cancer Center
2010-2024
Imam Sadiq University
2024
University of New Haven
2015-2019
Karolinska Institutet
2019
Turku University Hospital
2019
Oslo University Hospital
2011
Itron (United States)
2011
Institut d'Imagerie Biomédicale
2005-2007
Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative 19 transporters across nine different neurotransmitter systems. We found that profiles...
Significance Neuroinflammation is a brain immune response that associated with neurodegenerative diseases and primarily driven by activation of microglia, the brain’s resident macrophages. Dysfunctional microglial may contribute to behavioral changes observed in diseases. Upon activation, microglia express translocator protein, which can be imaged radiotracer [ 11 C]PBR28 positron emission tomography (PET) living human brain. We healthy subjects PET before after i.v. administration...
Synaptic vesicle glycoprotein 2A (SV2A) is ubiquitously present in presynaptic terminals. Here we report kinetic modeling and test-retest reproducibility assessment of the SV2A positron emission tomography (PET) radioligand [11C]UCB-J humans. Five volunteers were examined twice on HRRT after bolus injection [11C]UCB-J. Arterial blood samples collected for measurements radiometabolites free fraction. Regional time-activity curves analyzed with 1-tissue (1T) 2-tissue (2T) compartment models to...
The role of the norepinephrine transporter (NET) in cocaine dependence has never been demonstrated via vivo imaging due to lack suitable NET radioligands. Here we report our preliminary studies evaluting individuals with (COC) comparison healthy controls (HC) using (S,S)-[(11)C]methylreboxetine ([(11)C]MRB), most promising C-11 labeled positron-emission tomography (PET) radioligand for developed date.
Animal data suggest that chronic stress is associated with a reduction in norepinephrine transporter (NET) availability the locus coeruleus. However, it unclear whether such models are relevant to posttraumatic disorder (PTSD), which has been linked noradrenergic dysfunction humans.
The purpose of this study was to investigate the effects ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) radioligand [11C]PBR28. [11C]PBR28 data from 140 volunteers (72 males 68 females; N = 78 with HAB 62 MAB genotype; age range 19–80 years; BMI 17.6–36.9) were acquired High Resolution Research Tomograph at three centres: Karolinska Institutet (N 53), Turku PET centre 62) Yale University Center...
The Brain Imaging Data Structure (BIDS) is a standard for organizing and describing neuroimaging datasets, serving not only to facilitate the process of data sharing aggregation, but also simplify application development new methods software working with data. Here, we present an extension BIDS include positron emission tomography (PET) data, known as PET-BIDS, share several open-access datasets curated following PET-BIDS along tools conversion, validation analysis datasets.
Abstract Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise loss of synapses PD and other disorders. Here, we provide new clinical insights a cross-sectional, high-resolution positron emission tomography (PET) study 30 individuals age- sex-matched healthy controls (HC) with radiotracer [ 11 C]UCB-J, which binds to synaptic vesicle...
Purpose: Motion correction in PET has become more important as system resolution improved. The purpose of this study was to evaluate the accuracy event‐by‐event and frame‐based MC methods human brain imaging. Methods: compensated image reconstructions were performed with static dynamic simulated high research tomograph data reconstructions, using a range measured head motion data. Image intensities high‐contrast regions interest (ROI) parameter estimates tracer kinetic models assessed...
Objectives. Although serotonergic mechanisms have been implicated in pathological gambling (PG), no ligand-based imaging studies assessed serotonin receptors individuals with PG. Given its role substance addictions and abundance brain regions PG, we evaluated 1B (5-HT1BRs) Methods. Ten medication-free subjects PG (mean ± SD age = 36.3 9.4 years, nine men) ten control comparison (CC) 35.8 9.9 underwent [11C]P943 positron emission scanning on a high resolution research tomograph. Results....
Although [¹¹C]-(+)-PHNO has enabled quantification of the dopamine-D3 receptor (D3R) in human brain vivo, its selectivity for D3R is not sufficiently high to allow us disregard binding dopamine-D2 (D2R). We quantified affinity D2R and living primate brain. Two rhesus monkeys were examined on four occasions each, with administered a bolus + infusion paradigm. Varying doses unlabeled (+)-PHNO coadministered each occasion (total ranging from 0.09 5.61 μg kg⁻¹). The regional potential (BP(ND) )...
Detecting fluctuations in synaptic dopamine levels extrastriatal brain regions with [ 11 C]FLB 457 and positron emission tomography (PET) is a valuable tool for studying dopaminergic dysfunction psychiatric disorders. The evaluation of reference region modeling approaches would eliminate the need to obtain arterial input function data. Our goal was explore use models estimate amphetamine-induced changes D2/D3 binding. Six healthy tobacco smokers were imaged at baseline 3 hours after...
11C-UCB-J is a new PET tracer for synaptic density imaging. Recently, we conducted on patients with mild cognitive impairment or early Alzheimer disease (AD) and found 41% decrease in specific binding the hippocampus compared healthy subjects. We hypothesized that may have potential to be general biomarker evaluating AD treatment effects via monitoring of changes. In this study, performed longitudinal mice measure saracatinib, which previously demonstrated changes postmortem methods....
Abstract Objective In this positron emission tomography (PET) study with [ 11 C]UCB‐J, we evaluated synaptic vesicle glycoprotein 2A (SV2A) binding, which is decreased in resected brain tissues from epilepsy patients, subjects temporal lobe (TLE) and compared the regional binding pattern to 18 F]fluorodeoxyglucose (FDG) uptake. Methods Twelve TLE 12 control were examined. Regional C]UCB‐J potential ( BP ND ) values estimated using centrum semiovale as a reference region. F]FDG uptake was...
Arterial blood sampling is the gold standard method to obtain arterial input function (AIF) for quantification of whole body (WB) dynamic
Sites of early neuropathologic change provide important clues regarding the initial clinical features Alzheimer's disease (AD). We have shown significant reductions in hippocampal synaptic density participants with AD, consistent degeneration entorhinal cortical (ERC) cells that project to hippocampus via perforant path. In this study, [11C]UCB-J binding vesicle glycoprotein 2A (SV2A) and [18F]flortaucipir tau were measured PET 10 AD (5 mild cognitive impairment, 5 dementia) cognitively...
Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from >1 200 healthy individuals to construct a whole-brain 3-D normative 19 transporters across 9 different neurotransmitter systems. We find that profiles align with structural...