A5052288115- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Bone and Joint Diseases
- Immunotherapy and Immune Responses
- Neurogenesis and neuroplasticity mechanisms
- Glioma Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Drug Transport and Resistance Mechanisms
- Polyomavirus and related diseases
- Neuroscience and Neuropharmacology Research
- Brain Metastases and Treatment
- Systemic Lupus Erythematosus Research
- Gene expression and cancer classification
- Bacterial Infections and Vaccines
- CNS Lymphoma Diagnosis and Treatment
- interferon and immune responses
- Amyotrophic Lateral Sclerosis Research
- SARS-CoV-2 and COVID-19 Research
- Tryptophan and brain disorders
- Advanced MRI Techniques and Applications
- Histone Deacetylase Inhibitors Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
Turku PET Centre
2014-2025
Turku University Hospital
2014-2025
University of Turku
2017-2025
Åbo Akademi University
2022-2025
University Hospital of Basel
2020
University of Manchester
2018
Essen University Hospital
2018
Abstract Overactivation of microglia is associated with most neurodegenerative diseases. In this study we examined whether PET-measurable innate immune cell activation predicts multiple sclerosis disease progression. Activation microglia/macrophages was measured using the 18-kDa translocator protein (TSPO)-binding radioligand 11C-PK11195 and PET imaging in 69 patients 18 age- sex-matched healthy controls. Radioligand binding evaluated as distribution volume ratio from dynamic images....
The purpose of this study was to investigate the effects ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) radioligand [11C]PBR28. [11C]PBR28 data from 140 volunteers (72 males 68 females; N = 78 with HAB 62 MAB genotype; age range 19–80 years; BMI 17.6–36.9) were acquired High Resolution Research Tomograph at three centres: Karolinska Institutet (N 53), Turku PET centre 62) Yale University Center...
Traditionally, multiple sclerosis (MS) has been considered a white matter disease with focal inflammatory lesions. It is, however, becoming clear that significant pathology, such as microglial activation, also takes place outside the plaque areas, in areas of normal-appearing (NAWM) and gray (GM). Microglial activation can be detected vivo using 18-kDa translocator protein (TSPO)–binding radioligands PET. is unknown whether fingolimod affects MS. The aim this study was to investigate serial...
To investigate the relationship of in vivo microglial activation to clinical and MRI parameters MS.Patients with secondary progressive MS (n = 10) or relapsing-remitting age-matched healthy controls 17) were studied. Microglial was measured using PET radioligand [11C](R)-PK11195. Clinical assessment structural quantitative including diffusion tensor imaging (DTI) performed for comparison.[11C](R)-PK11195 binding significantly higher normal-appearing white matter (NAWM) patients vs relapsing...
To evaluate whether natalizumab treatment reduces microglial activation in MS.We measured using the 18-kDa translocator protein (TSPO)-binding radioligand [11C]PK11195 and PET imaging 10 patients with MS before after 1 year natalizumab. Microglial was evaluated as distribution volume ratio (DVR) of specifically bound brain white gray matter regions interest. MRI disability measurements were performed for comparison. Evaluation identically 11 age- sex-matched who had no therapy.Natalizumab...
In the multiple sclerosis (MS) brain, chronic active lesions can be detected using MRI- and PET-based methods. this study, we investigated whether frequency of TSPO-PET-detectable associates with disease progression measured Expanded Disability Status Scale (EDSS) at 5-year follow-up.Chronic lesion-associated innate immune cell activation was evaluated TSPO-PET in 82 patients MS. Chronic were categorized into rim-active, inactive, overall lesion subtypes based on patterns core 2-mm...
Abstract Purpose In clinical practice, we observed an apparent overrepresentation of COVID-19 patients on anti-CD20 monoclonal antibody therapy. The aim this study was to characterize the picture in these patients. Methods All adult from Turku University Hospital, Turku, Finland, with diagnosis and/or positive SARS-CoV-2 PCR test result up March 2023, and therapy within 12 months before were included. Data retrospectively obtained electronic patient records. Results Ninety-eight identified....
To evaluate to which extent serum neurofilament light chain (NfL) increase is related diffusion tensor imaging-MRI measurable diffuse normal-appearing white matter (NAWM) damage in MS.Seventy-nine patients with MS and 10 healthy controls underwent MRI including sequences NfL determination by single molecule array (Simoa). Fractional anisotropy mean, axial, radial diffusivities were calculated within the whole segmented (frontal, parietal, temporal, occipital, cingulate, deep) NAWM. Spearman...
<h3>Objective</h3> To evaluate in vivo the co-occurrence of microglial activation and microstructural white matter (WM) damage MS brain to examine their association with clinical disability. <h3>Methods</h3> 18-kDa translocator protein (TSPO) PET imaging was performed for evaluation by using radioligand [<sup>11</sup>C](R)-PK11195. TSPO binding evaluated as distribution volume ratio (DVR) from dynamic images. Diffusion tensor (DTI) conventional MRI (cMRI) were at same time. Mean fractional...
Background Predicting disease progression in multiple sclerosis (MS) remains challenging. PET imaging with 18 kDa translocator protein (TSPO) radioligands can detect microglial and astrocyte activation beyond MRI-visible lesions, which has been shown to be highly predictive of progression. We previously demonstrated that nuclear magnetic resonance (NMR)-based metabolomics could accurately distinguish between relapsing-remitting (RRMS) secondary progressive MS (SPMS). This study investigates...
Chronic active lesions are promotors of neurodegeneration and disease progression in multiple sclerosis. They harbour a dense rim activated innate immune cells at the lesion edge, which promotes growth thereby induces damage. Conventional MRI is limited help identifying chronic lesions, so alternative imaging modalities needed. Objectives were to develop PET-based automated analysis method for phenotyping based on lesion-associated cell activation comprehensively evaluate prevalence these...
Translocator protein (TSPO)-PET and neurofilament light (NfL) both report on brain pathology, but their potential association has not yet been studied in multiple sclerosis (MS) vivo. We aimed to evaluate the between serum NfL (sNfL) TSPO-PET-measurable microglial activation of patients with MS.Microglial was detected using PET TSPO-binding radioligand [11C]PK11195. Distribution volume ratio (DVR) used specific [11C]PK11195-binding. sNfL levels were measured single molecule array (Simoa)....
BackgroundThere are already numerous B-cell depleting monoclonal anti-CD20 antibodies which have been used to reduce the inflammatory burden associated with multiple sclerosis (MS). We describe here our experience of treating MS-patients rituximab.Patients and methodsAll (n = 72) who had received rituximab treatment for at least six months by January 2019 were identified from patient charts Turku University Hospital. Information about MS disease subtype, severity, MR-imaging outcomes counts...
Our aim was to investigate whether 18-kDa translocator protein (TSPO) radioligand binding in gray matter (GM) predicts later disability progression multiple sclerosis (MS).In this prospective imaging study, innate immune cells were investigated the MS patient brain using PET imaging. The distribution volume ratio (DVR) of TSPO-binding [11C]PK11195 determined 5 GM regions: thalamus, caudate, putamen, pallidum, and cortical GM. Volumetric MRI parameters obtained for comparison. Expanded...
BackgroundMicroglial activation associates with MS progression but it is unclear what drives their persistent pro-inflammatory state. Metabolites of the kynurenine pathway (KP), main metabolism route tryptophan, can influence function brain innate immune cells.ObjectiveTo investigate whether tryptophan metabolites in blood associate TSPO-PET measurable microglial brain.MethodsMicroglial was detected using PET imaging and TSPO-binding radioligand [11C]PK11195. Distribution volume ratios (DVR)...
The aim was to study brain innate immune cell activation in teriflunomide-treated patients with relapsing-remitting multiple sclerosis.Imaging 18-kDa translocator protein positron emission tomography (TSPO-PET) using the [11 C]PK11195 radioligand employed assess microglial activity white matter, thalamus and areas surrounding chronic matter lesions 12 sclerosis who had been treated teriflunomide for at least 6 months before inclusion. Magnetic resonance imaging (MRI) used measure lesion load...
Factors driving increased innate immune cell activation in multiple sclerosis (MS) brain are not well understood. As higher prevalence of microglial/macrophage association with chronic lesions and diffusely the normal appearing white matter predict more rapid accumulation clinical disability, it is high importance to understand processes behind this. Objective study was explore demographic, paraclinical variables associating later positron emission tomography (PET)-measurable activation....
<title>Abstract</title> Background PET imaging of activated microglia has improved our understanding the pathology behind disability progression in MS, and pro-inflammatory at ‘smoldering’ lesion rims have been implicated as drivers progression. The P2X<sub>7</sub>R is upregulated cellular membranes microglia. A single-tissue dual-input model was applied to quantify binding normal appearing white matter, perilesional areas thalamus among progressive MS patients, healthy controls newly...
PET imaging of activated microglia has improved our understanding the pathology behind disability progression in MS, and pro-inflammatory at 'smoldering' lesion rims have been implicated as drivers progression. The P2X 7R is upregulated cellular membranes microglia. A single-tissue dual-input model was applied to quantify binding normal appearing white matter, perilesional areas thalamus among progressive MS patients, healthy controls newly diagnosed relapsing patients. Overall, tracer...
<h3>Objective:</h3> To evaluate how natalizumab treatment impacts innate immune cell activation at chronic lesion edge. <h3>Background:</h3> Increased has been associated with multiple sclerosis progression and neurodegeneration. We have demonstrated a reduction in microglial the normal appearing white matter (NAWM) after treatment. Later, TSPO-PET-based method for phenotyping of T1-lesions based on core rim was developed. The impact high-efficacy MS-treatments edge active lesions is not yet...
Abstract Purpose To investigate the effects of ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) radioligand [ 11 C]PBR28. Methods C]PBR28 data from 140 volunteers (72 males 68 females; n=78 with HAB n=62 MAB genotype; age range 19-80 years; BMI 17.6 - 36.9) were acquired High Resolution Research Tomograph at three centres: Karolinska Institutet (n=53), Turku PET centre (n=62) Yale University Center...
In preclinical models of multiple sclerosis (MS), both adiabatic T1rho (T1ρadiab ) and relaxation along a fictitious field (RAFF) imaging have demonstrated potential to noninvasively characterize MS.To evaluate the feasibility whole brain T1ρadiab RAFF in healthy volunteers patients with MS.Single institutional clinical trial.38 (24-69 years) 21 (26-59 MS. Five underwent second MR examination performed within 8 days. Clinical disease severity (The Expanded Disability Status Scale [EDSS] The...