A5046378639- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Nicotinic Acetylcholine Receptors Study
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Biotin and Related Studies
- Immune cells in cancer
- Radiation Detection and Scintillator Technologies
- Tryptophan and brain disorders
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Pain Mechanisms and Treatments
- Cellular transport and secretion
- Genetics and Neurodevelopmental Disorders
- Medical Image Segmentation Techniques
- Neurological diseases and metabolism
- Sparse and Compressive Sensing Techniques
Invicro (United States)
2018-2025
Konica Minolta (United States)
2019-2021
Karolinska Institutet
2019
Turku University Hospital
2019
Elucid Bioimaging
2018
Yale University
2008-2017
Yale Cancer Center
2015-2017
Significance Neuroinflammation is a brain immune response that associated with neurodegenerative diseases and primarily driven by activation of microglia, the brain’s resident macrophages. Dysfunctional microglial may contribute to behavioral changes observed in diseases. Upon activation, microglia express translocator protein, which can be imaged radiotracer [ 11 C]PBR28 positron emission tomography (PET) living human brain. We healthy subjects PET before after i.v. administration...
A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately treatment of α-synuclein-related diseases. Here we show that PET ligand, [
The purpose of this study was to investigate the effects ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) radioligand [11C]PBR28. [11C]PBR28 data from 140 volunteers (72 males 68 females; N = 78 with HAB 62 MAB genotype; age range 19–80 years; BMI 17.6–36.9) were acquired High Resolution Research Tomograph at three centres: Karolinska Institutet (N 53), Turku PET centre 62) Yale University Center...
Detecting fluctuations in synaptic dopamine levels extrastriatal brain regions with [ 11 C]FLB 457 and positron emission tomography (PET) is a valuable tool for studying dopaminergic dysfunction psychiatric disorders. The evaluation of reference region modeling approaches would eliminate the need to obtain arterial input function data. Our goal was explore use models estimate amphetamine-induced changes D2/D3 binding. Six healthy tobacco smokers were imaged at baseline 3 hours after...
Findings from clinical and preclinical studies converge to suggest that increased adiposity and/or exposure a high fat diet are associated with alterations in dorsal striatal (DS) circuitry. In humans there is reliable inverse relationship between body mass index (BMI) response palatable food consumption the striatum (DS). Positron emission tomography (PET) also altered DS dopamine type 2/3 receptor (D2R/D3R) availability obesity; however, direction of association unclear. It not clear...
Detecting changes in receptor binding at the metabotropic glutamate 5 (mGluR5) with PET allosteric antagonist, [¹¹C]ABP688, may be valuable for studying dysfunctional transmission associated psychiatric illnesses. This study was designed to validate findings of a recent pilot baboons which reported significant global decrease from baseline [¹¹C]ABP688 after increasing endogenous 50 mg/kg N-acetylcysteine (NAC), no change test retest. In rhesus monkeys (n = 5), paired scans were performed on...
Therapeutic interventions are being developed for Huntington's disease (HD), a hallmark of which is mutant huntingtin protein (mHTT) aggregates. Following the advancement to human testing two [11C]-PET ligands aggregated mHTT, attributes further optimization were identified. We replaced pyridazinone ring CHDI-180 with pyrimidine and minimized off-target binding using brain homogenate derived from Alzheimer's patients. The major in vivo metabolic pathway via aldehyde oxidase was blocked...
<sup>18</sup>F-PI-2620 is a next-generation tau PET tracer that has demonstrated ability to image the spatial distribution of suspected pathology. The objective this study was assess biodistribution, dosimetry, and quantitative methods in human brain. Full kinetic modeling quantify load investigated. Noninvasive semiquantitative were evaluated against full kinetics. Finally, reproducibility measurements from test retest scans assessed. <b>Methods:</b> Three healthy controls (HCs) 4 Alzheimer...
Abstract Purpose The accumulation of misfolded tau is a common feature several neurodegenerative disorders, with Alzheimer’s disease (AD) being the most common. Earlier we identified JNJ-64326067, novel isoquinoline derivative high affinity and selectivity for aggregates from human AD brain. We report dosimetry [ 18 F] JNJ-64326067 results proof-of-concept study comparing subjects probable to age-matched healthy controls. Methods PET scans were acquired 90 min then 120 180 in 5 participants...
<title>Abstract</title> Synucleinopathies are neurodegenerative diseases characterized by the presence of brain inclusions containing pathologically aggregated protein α-synuclein (αSYN). The development a positron emission tomography tracer to detect aggregates misfolded αSYN would revolutionize disease monitoring and evaluation therapeutic efficacy. Here we present preclinical in vitro vivo validation [<sup>11</sup>C]MODAG-005. In binding experiments demonstrate subnanomolar affinity...
Neuroreceptor imaging in the nonhuman primate (NHP) is valuable for translational research approaches humans. However, most NHP studies are conducted under anesthesia, which affects interpretability of receptor binding measures. The aims this study were to develop awake with minimal head restraint and compare vivo γ-aminobutyric acid type A (GABA<sub>A</sub>)-benzodiazepine radiotracer <sup>11</sup>C-flumazenil anesthetized conditions. We hypothesized that potential (<i>BP</i><sub>ND</sub>)...
Abstract Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are distinct clinicopathological subtypes of frontotemporal lobar degeneration. They both have atypical parkinsonism, they usually clinical features. The most common presentation PSP is Richardson syndrome, the CBD syndrome. In this report, we describe a patient with five-year history syndrome family in her mother sister. A tau PET scan ( 18 F-APN-1607) revealed low-to-moderate uptake substantia nigra, globus...
PET imaging of nonhuman primates (NHPs) requires correction head motion if the subjects are scanned awake and their heads unrestrained, because NHPs move faster more frequently than human subjects. This work focuses on designing validating 2 motion-correction algorithms for NHP brain imaging.Two methods were implemented imaging: multiacquisition frame (MAF) event-by-event (EBE). Motion data acquired from an external motion-tracking device. The MAF method divides scan into short subframes,...
Background Alcohol dependence and tobacco smoking are highly comorbid, treating both conditions simultaneously is controversial. Previously, we showed that interferes with GABA A receptor neuroadaptations during alcohol withdrawal in humans, while this effect did not occur continued nicotine use abstinence nonhuman primates. Here, extend our previous work by measuring availability positron emission tomography ( PET ) drug primates exposed to alone, together, exposure. Methods Twenty‐four...
Histone methylation is associated with the pathophysiology of neurodevelopmental disorders. Lysine-specific demethylase 1 (LSD1) catalyzes histone demethylation in a flavin adenine dinucleotide (FAD)-dependent manner. Thus, inhibiting LSD1 enzyme activity could offer novel way to treat Assessing target engagement using positron-emission tomography (PET) imaging aid developing therapeutic inhibitors. In this study, PET probes based on 4-(2-aminocyclopropyl)benzamide derivatives that bind...