A5080323147- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Psoriasis: Treatment and Pathogenesis
- Medical Imaging Techniques and Applications
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- COVID-19 Clinical Research Studies
- Advanced MRI Techniques and Applications
- Receptor Mechanisms and Signaling
- Bipolar Disorder and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Stress Responses and Cortisol
- Eating Disorders and Behaviors
- Electroconvulsive Therapy Studies
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Diet and metabolism studies
- Radiomics and Machine Learning in Medical Imaging
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Intensive Care Unit Cognitive Disorders
- Pharmacology and Obesity Treatment
- Neuropeptides and Animal Physiology
University of Manchester
2016-2025
Manchester Academic Health Science Centre
2011-2024
Royal Free London NHS Foundation Trust
2024
University of Oxford
2022-2023
Greater Manchester Mental Health NHS Foundation Trust
2017-2022
Public Health Scotland
2021
National Health and Medical Research Council
2021
Intensive Care National Audit & Research Centre
2021
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
These updated guidelines from the British Association for Psychopharmacology replace original version published in 2011. They address scope and targets of pharmacological treatment schizophrenia. A consensus meeting was held 2017, involving experts schizophrenia its treatment. were asked to review key areas consider strength evidence on risk-benefit balance interventions clinical implications, with an emphasis meta-analyses, systematic reviews randomised controlled trials where available,...
OBJECTIVE: The serotonin system is believed to play a role in modulating impulsivity and violence. Previous imaging studies have implicated the anterior cingulate orbitofrontal cortex impulsive aggression. This study evaluated regional transporter distribution brain of individuals with aggression by using positron emission tomography (PET) PET radiotracer [11C]McN 5652. METHOD: Ten 10 age- sex-matched healthy comparison subjects underwent 5652 PET. All were medication free at time scanning....
The variability in the response to antipsychotic medication schizophrenia may reflect between-patient differences neurobiology. Recent cross-sectional neuroimaging studies suggest that a poorer therapeutic is associated with relatively normal striatal dopamine synthesis capacity but elevated anterior cingulate cortex (ACC) glutamate levels. We sought test whether these measures can differentiate patients psychosis who are responsive from those nonresponsive multicenter study. 1H-magnetic...
OBJECTIVE: Ketamine is a noncompetitive antagonist at the glutamatergic N-methyl-d-aspartate (NMDA) receptor that used in human and animal medicine as an injectable anesthetic. The illegal use of ketamine recreational drug rapidly growing. Very little currently known about consequences repeated exposure brain. Animal studies indicate prefrontal dopaminergic system particularly vulnerable to toxic effects administration NMDA antagonists. In this study, dopamine D1 availability was assessed by...
Abstract (–)‐N‐Propyl‐norapomorphine (NPA) is a full dopamine (DA) D 2 receptor agonist and [ 11 C]NPA suitable radiotracer to image receptors configured in state of high affinity for agonists with positron emission tomography (PET). In this study the vulnerability vivo binding acute fluctuation synaptic DA was assessed PET baboons compared that reference antagonist C]raclopride. Three male were studied C]raclopride under baseline conditions following administration potent releaser...
Iterative image reconstruction methods such as ordered-subset expectation maximization (OSEM) are widely used in PET. Reconstructions via OSEM however reported to be biased for low-count data. We investigated this and considered the impact dynamic Patient listmode data were acquired [11C]DASB [15O]H2O scans on HRRT brain PET scanner. These subsampled create many independent, replicates. The reconstructed images from compared high-count originals (from same method). This comparison enabled...
To investigate the relationship of in vivo microglial activation to clinical and MRI parameters MS.Patients with secondary progressive MS (n = 10) or relapsing-remitting age-matched healthy controls 17) were studied. Microglial was measured using PET radioligand [11C](R)-PK11195. Clinical assessment structural quantitative including diffusion tensor imaging (DTI) performed for comparison.[11C](R)-PK11195 binding significantly higher normal-appearing white matter (NAWM) patients vs relapsing...
Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major episodes, which contribute greatly to the high levels disability and mortality associated disorder. Despite importance depression, there are only small number recognised treatment options available. Consecutive failures can quickly exhaust these leading treatment-resistant depression (TRBD). Remarkably few studies have evaluated TRBD those available...
Deep brain stimulation (DBS) of the periaqueductal gray (PAG) is used in treatment severe refractory neuropathic pain. We tested hypothesis that DBS releases endogenous opioids to exert its analgesic effect using [11C]diprenorphine (DPN) positron emission tomography (PET). Patients with de-afferentation pain (phantom limb or Anaesthesia Dolorosa (n=5)) who obtained long-lasting benefit from were recruited. [11C]DPN and [15O]water PET scanning was performed consecutive sessions; first...
It is a growing concern that outcomes of neuroimaging studies often cannot be replicated. To counteract this, the magnetic resonance (MR) community has promoted acquisition standards and created data sharing platforms, based on consensus how to organize share MR data. Here, we take similar approach positron emission tomography (PET) facilitate comparison findings across studies, first recommend publication for tracer characteristics, image acquisition, preprocessing, outcome estimation PET...
Abstract Positron emission tomography (PET) imaging of the 18 kDa translocator protein (TSPO), which is upregulated in activated microglia, a method for investigating whether immune activation evident brain adults with schizophrenia. This study aimed to measure TSPO availability largest patient group date, and compare it between patients recent onset (ROS) established (ES) In total, 20 ROS (14 male), 21 ES (13 healthy controls completed study. Patients were predominantly...
Eating behaviour, nutritional intake and psychopathology were examined in 16 weight-recovered anorexia nervosa patients. The Disorders Examination (EDE) a food diary the main outcome measures, but body fat content psychosocial adjustment also assessed. Although overall had returned to normal most patients, 12 still restricted eating pattern with below 90% of their energy requirements. These results suggest that weight, menstruation, criteria are not sufficient determine full recovery from...
Although abnormal serotonin (5-HT) function is implicated in a range of mental disorders, there currently no method to directly assess 5-HT synaptic levels the living human brain. The vivo binding some dopamine (DA) radioligands such as (11)C-raclopride affected by fluctuations endogenous DA, thus providing an indirect measure DA presynaptic activity. Attempts identify serotonergic radiotracer with similar properties have proved unsuccessful. Here, we investigated humans effects reduced on...
Abstract Molecular neuroimaging techniques, like PET and SPECT, offer invaluable insights into the brain’s in-vivo biology its dysfunction in neuropsychiatric patients. However, transition of molecular diagnostics precision medicine has been limited to a few clinical applications, hindered by issues practical feasibility, high costs, between-subject heterogeneity measures. In this study, we explore use normative modelling (NM) identify individual patient alterations describing physiological...