A5015102333- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Pharmacological Effects and Toxicity Studies
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Cancer Treatment and Pharmacology
- Tryptophan and brain disorders
- Psychosomatic Disorders and Their Treatments
- Drug-Induced Ocular Toxicity
- Neuroscience and Neuropharmacology Research
- Neurological and metabolic disorders
- Metabolism and Genetic Disorders
- Parkinson's Disease and Spinal Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Pharmaceutical studies and practices
- Mental Health and Psychiatry
- Memory and Neural Mechanisms
- Drug-Induced Adverse Reactions
- Mental Health Treatment and Access
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Forensic Toxicology and Drug Analysis
Newcastle University
2016-2025
Cumbria Northumberland Tyne and Wear NHS Foundation Trust
2016-2025
University of Newcastle Australia
2002-2024
Imperial College London
2022-2024
Clinical Research Institute
2020-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2021-2023
University of Oxford
2019-2023
St Nicholas Hospital
2023
Collaborative Group (United States)
2023
Restore America's Estuaries
2023
The British Association for Psychopharmacology guidelines specify the scope and target of treatment bipolar disorder. second version, like first, is based explicitly on available evidence presented, previous Clinical Practice guidelines, as recommendations to aid clinical decision making practitioners: they may also serve a source information patients carers. are presented together with more detailed but selective qualitative review evidence. A consensus meeting, involving experts in...
A revision of the 2008 British Association for Psychopharmacology evidence-based guidelines treating depressive disorders with antidepressants was undertaken in order to incorporate new evidence and update recommendations where appropriate. consensus meeting involving experts their management held September 2012. Key areas depression were reviewed strength clinical implications considered. The then revised after extensive feedback from participants interested parties. literature review is...
A revision of the 2000 British Association for Psychopharmacology evidence-based guidelines treating depressive disorders with antidepressants was undertaken to incorporate new evidence and update recommendations where appropriate. consensus meeting involving experts in their management held May 2006. Key areas depression were reviewed, strength clinical implications considered. The drawn up after extensive feedback from participants interested parties. literature review is provided, which...
Treatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD demonstrated predictive utility in terms clinical decision-making outcomes does not currently exist. Instead, a plethora definitions have been proposed, which vary significantly their conceptual framework. The absence hampers precise estimates the prevalence TRD, also belies efforts to identify risk factors, prevention opportunities, effective...
Decisions about the use of psychotropic medication in pregnancy are an ongoing challenge for clinicians and women with mental health problems, owing to uncertainties around risks illness itself mother fetus/infant, effectiveness medications fetus/infant from utero exposure or via breast milk. These consensus guidelines aim provide pragmatic advice regarding these issues. They divided into sections on untreated pregnancy; general principles using drugs perinatal period; benefits harms...
Abstract Disruption in reciprocal connectivity between the right anterior insula and left dorsolateral prefrontal cortex is associated with depression may be a target for neuromodulation. In five-center, parallel, double-blind, randomized controlled trial we personalized resting-state functional magnetic resonance imaging neuronavigated connectivity-guided intermittent theta burst stimulation (cgiTBS) at site based on effective from to cortex. We tested its efficacy reducing primary outcome...
The effects of in utero exposure to atypical antipsychotics on infant birth weight are unknown.To determine whether and typical differ their after maternal during pregnancy.Prospective data gestational age collected by the National Teratology Information Service for infants exposed (n=45) (n=25) was compared with a reference group (n=38).Infants had significantly higher incidence large (LGA) than both comparison groups mean heavier those antipsychotics. In contrast lower small group.In...
Background Subjective reports of insomnia and hypersomnia are common in bipolar disorder (BD). It is unclear to what extent these relate underlying circadian rhythm disturbance (CRD). In this study we aimed objectively assess sleep a cohort patients with BD compared matched controls. Method Forty-six 42 controls had comprehensive sleep/circadian assessment respiratory studies, prolonged accelerometry over 3 weeks, questionnaires diaries, melatonin levels, alongside mood, psychosocial...
BackgroundThe use of electroconvulsive therapy (ECT) is limited by concerns about its cognitive adverse effects. Preliminary evidence suggests that administering the glutamate antagonist ketamine with ECT might alleviate effects and accelerate symptomatic improvement; we tested this in a randomised trial low-dose ketamine.MethodsIn multicentre, randomised, parallel-group study 11 suites serving inpatient outpatient care settings seven National Health Service trusts North England, recruited...
Anxiety disorders are very prevalent and often persistent mental disorders, with a considerable rate of treatment resistance which requires regulatory clinical trials innovative therapeutic interventions. However, an explicit definition treatment-resistant anxiety (TR-AD) informing such is currently lacking. We used Delphi method-based consensus approach to provide internationally agreed, consistent clinically useful operational criteria for TR-AD in adults. Following summary the current...
An increasing number of studies are utilizing saliva sampling as a method assessing adrenal steroid secretion. Saliva samples have certain advantages over plasma, being non-invasive and easily collected. However, some methods collection may compromise the accuracy assay, particularly those which employ aids to stimulate production. We sought compare cortisol dehydroepiandrosterone (DHEA) measurement by examining association between plasma levels, collected using citric acid-treated salivette...
Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major episodes, which contribute greatly to the high levels disability and mortality associated disorder. Despite importance depression, there are only small number recognised treatment options available. Consecutive failures can quickly exhaust these leading treatment-resistant depression (TRBD). Remarkably few studies have evaluated TRBD those available...
The British Association for Psychopharmacology and the National of Psychiatric Intensive Care Low Secure Units developed this joint evidence-based consensus guideline clinical management acute disturbance. It includes recommendations practice an algorithm to guide treatment by healthcare professionals with various options outlined according their route administration category evidence. Fundamental overarching principles are included highlight importance treating underlying disorder. There is...
Lithium and quetiapine are first-line augmentation options for treatment-resistant depression; however, few studies have compared them directly, none longer than 8 weeks. We aimed to assess whether therapy is more clinically effective cost-effective lithium patients with depression over 12 months. did this pragmatic, open-label, parallel-group, randomised controlled superiority trial at six National Health Service trusts in England. Eligible participants were adults (aged ≥18 years) a...