A5003551209- Medical Imaging Techniques and Applications
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Glioma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Drug Transport and Resistance Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Lanthanide and Transition Metal Complexes
- Advanced Neuroimaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Cardiac Imaging and Diagnostics
- S100 Proteins and Annexins
- Radiomics and Machine Learning in Medical Imaging
- Radiation Detection and Scintillator Technologies
- Functional Brain Connectivity Studies
- Pharmacological Effects and Toxicity Studies
- Advanced Radiotherapy Techniques
- Medical Practices and Rehabilitation
- Parkinson's Disease Mechanisms and Treatments
University of Manchester
2015-2024
Manchester Academic Health Science Centre
2013-2024
Université de Tours
2024
Salford Royal NHS Foundation Trust
2021
University of Duisburg-Essen
2021
University of London
2019
Imperial College London
2006-2019
Aarhus University
2019
Vita-Salute San Raffaele University
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
<b>Objective: </b> To investigate the association between brain amyloid load in Alzheimer disease (AD) measured by [11C]PIB-PET, regional cerebral glucose metabolism (rCMRGlc) [18F]FDG-PET, and cognition. <b>Methods: Nineteen subjects with AD 14 controls had [11C]PIB-PET underwent a battery of psychometric tests. Twelve those eight [18F]FDG-PET. Parametric images [11C]PIB binding rCMRGlc were interrogated region-of-interest atlas statistical parametric mapping. correlated scores on...
Alzheimer's disease is characterized by the histopathological presence of amyloid-β plaques and tau-containing neurofibrillary tangles. Microglial activation also a recognized pathological component. The relationship between microglial protein aggregation still debated. We investigated amyloid plaques, tau tangles activated microglia using PET imaging. Fifty-one subjects (19 healthy controls, 16 mild cognitive impairment subjects) participated in study. All had neuropsychometric testing,...
See Kreisl (doi:10.1093/awx151) for a scientific commentary on this article.Subjects with mild cognitive impairment associated cortical amyloid-β have greatly increased risk of progressing to Alzheimer's disease. We hypothesized that neuroinflammation occurs early in disease and would be present most amyloid-positive cases. 11C-Pittsburgh compound B 11C-(R)-PK11195 positron emission tomography was used determine the amyloid load detect extent (microglial activation) 42 Twelve age-matched...
Abstract Brain network dysfunction is increasingly recognised in Alzheimer’s disease (AD). However, the causes of brain connectivity disruption are still poorly understood. Recently, neuroinflammation has been identified as an important factor AD pathogenesis. Microglia participate construction and maintenance healthy neuronal networks, but pro-inflammatory microglia can also damage these circuits. We hypothesised that microglial activation independently associated with AD. performed a...
Insertion of the transposon Tn5 into T-region octopine Ti plasmid Agrobacterium tumefaciens gives rise to crown gall tumors having altered morphology. Three loci within T-DNA that control tumor morphology have been detected [Garfinkel, D. J., Simpson, R. B., Ream, L. W., White, F. F., Gordon, M. P. & Nester, E. W. (1981) Cell 27, 143-153]. They influence size (tml), production roots (tmr), or shoots (tms). Cytokinin and auxin levels in such mutant were examined by HPLC/radioimmunoassay...
Objective: A previous positron emission tomography (PET) study reported increased serotonin 5-HT 2A receptor binding in unmedicated depressed patients with high scores on the Dysfunctional Attitudes Scale. The purpose of present was to use highly selective ligand [ 11 C]MDL 100,907 a PET imaging paradigm assess 1) potential euthymic subjects history recurrent depression and 2) relationship between Method: Cortical measured 20 unmedicated, fully recovered unipolar age- gender-matched...
Chronic systemic inflammatory conditions, such as atherosclerosis, diabetes and obesity are associated with increased risk of stroke, which suggests that inflammation may contribute to the development stroke in humans. The hypothesis induce brain pathology can be tested animals, this was key objective present study. First, we assessed changes rodent models chronic, inflammation. PET imaging revealed microglia activation JCR-LA (corpulent) rats, develop atherosclerosis obesity, compared...
Amyloid PET tracers have been developed for in vivo detection of brain fibrillar amyloid deposition Alzheimer's disease (AD). To serve as an early biomarker AD the need to be analysed multicentre clinical studies.In this study 238 [(11)C]Pittsburgh compound-B (PIB) datasets from five different European centres were pooled. Of these datasets, 18 excluded, leaving [(11)C]PIB 97 patients with clinically diagnosed (mean age 69 ± 8 years), 72 mild cognitive impairment (MCI; mean 67.5 years) and...
Performance of two supervised cluster analysis (SVCA) algorithms for extracting reference tissue curves was evaluated to improve quantification dynamic (R)-[(11)C]PK11195 brain positron emission tomography (PET) studies. Reference tissues were extracted from images using both a manually defined cerebellum and SVCA based on either four (SVCA4) or six (SVCA6) kinetic classes. Data controls, mild cognitive impairment patients, patients with Alzheimer's disease analyzed various models including...
Neuroinflammation is associated with neurodegenerative disease. PET radioligands targeting the 18-kDa translocator protein (TSPO) have been used as in vivo markers of neuroinflammation, but there an urgent need for novel probes improved signal-to-noise ratio. Flutriciclamide (18F-GE180) a recently developed third-generation TSPO ligand. In this first study, we evaluated optimum scan duration and kinetic modeling strategies 18F-GE180 (older) healthy controls.Ten controls, 6 high-affinity...
<h3>Objective</h3> To investigate the influence of microglial activation in early stages Alzheimer9s disease trajectory, we assessed relationship between and gray matter volume hippocampal patients with mild cognitive impairment (MCI). <h3>Methods</h3> In this study, 55 participants (37 MCI 18 controls) underwent [<sup>11</sup>C]PBR28 PET, a marker activation; volumetric MRI to evaluate volumes as well clinical neuropsychometric evaluation. V<sub>T</sub> (volume distribution) was calculated...
This article deals with the problem of model selection for mathematical description tracer kinetics in nuclear medicine. It stems from consideration some specific data sets where different models have similar performances. In these situations, it is shown that considerate averaging a parameter's estimates over entire set better than obtaining one only. Furthermore, also procedure small number “good” reduces “generalization error,” error introduced when selected particular applied to...
Animal and limited human data suggest an important anticonvulsant role for opioid peptides their receptors. We aimed to provide direct in vivo evidence changes receptor availability following spontaneous seizures. scanned nine patients within hours of temporal lobe seizures compared postictal binding the non-subtype selective PET radioligand [11C]diprenorphine (DPN), quantified as a volume-of-distribution (VD), with interictal 14 healthy controls, controlling range behavioural variables...
Inflammation is hypothesized to be a key event in the growth of sporadic vestibular schwannoma (VS). In this study we sought investigate relationship between inflammation and tumor vivo using PET tracer 11C-(R)-PK11195 dynamic contrast enhanced (DCE) MRI derived vascular biomarkers. Nineteen patients with VS (8 static, 7 growing, 4 shrinking tumors) underwent prospective imaging comprehensive MR protocol, including high temporal resolution DCE-MRI 15 patients. An intertumor comparison...
The 18-kDa mitochondrial translocator protein (TSPO) is upregulated in high-grade astrocytomas and can be imaged by PET using the selective radiotracer <sup>11</sup>C-(<i>R</i>)PK11195. We investigated <sup>11</sup>C-(<i>R</i>)PK11195 binding human gliomas its relationship with TSPO expression tumor tissue glioma-associated microglia/macrophages (GAMs) within tumors. <b>Methods:</b> Twenty-two glioma patients underwent dynamic scans perfusion MR imaging acquisition. Parametric maps of...
To investigate the relationship of in vivo microglial activation to clinical and MRI parameters MS.Patients with secondary progressive MS (n = 10) or relapsing-remitting age-matched healthy controls 17) were studied. Microglial was measured using PET radioligand [11C](R)-PK11195. Clinical assessment structural quantitative including diffusion tensor imaging (DTI) performed for comparison.[11C](R)-PK11195 binding significantly higher normal-appearing white matter (NAWM) patients vs relapsing...
Over the past 20 years, neuroinflammation (NI) has increasingly been recognised as having an important role in many neurodegenerative diseases, including Alzheimer's disease. As such, being able to image NI non-invasively patients is critical monitor pathological processes and potential therapies targeting neuroinflammation. The translocator protein (TSPO) proven a reliable biomarker for positron emission tomography (PET) imaging. However, if TSPO imaging acute conditions such stroke...