Paulo Crespo
A5030040711- Radiation Detection and Scintillator Technologies
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Particle Detector Development and Performance
- Dark Matter and Cosmic Phenomena
- Radiation Effects in Electronics
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Structural Health Monitoring Techniques
- Advanced X-ray and CT Imaging
- Solar and Space Plasma Dynamics
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Nuclear physics research studies
- Geomagnetism and Paleomagnetism Studies
- Advanced Semiconductor Detectors and Materials
- Vibration and Dynamic Analysis
- Environmental Toxicology and Ecotoxicology
- Nuclear reactor physics and engineering
- Luminescence Properties of Advanced Materials
- Effects of Radiation Exposure
- Particle accelerators and beam dynamics
University of Coimbra
2014-2024
LIP - Laboratory of Instrumentation and Experimental Particle Physics
2013-2024
Universidade de Vigo
2023
European Telecommunications Standards Institute
2013
Special Olympics
2013
Screen
2013
Helmholtz-Zentrum Dresden-Rossendorf
2003-2010
Daido University
2010
Triangle Universities Nuclear Laboratory
2010
Duke University
2010
In-beam positron emission tomography (in-beam PET) is currently the only method for an in situ monitoring of highly tumour-conformed charged hadron therapy. At experimental carbon ion tumour therapy facility, running at Gesellschaft für Schwerionenforschung, Darmstadt, Germany, all treatments have been monitored by means a specially adapted dual-head PET scanner. The positive clinical impact this project triggered construction hospital-based with in-beam expected to monitor more delicate...
We extrapolate the impact of recent detector and scintillator developments, enabling sub-nanosecond coincidence timing resolution (tau), onto in-beam positron emission tomography (in-beam PET) for monitoring charged-hadron radiation therapy. For tau < or = 200 ps full width at half maximum, information given by time-of-flight (TOF) difference between two opposing gamma-rays enables shift-variant, artefact-free tomographic imaging means limited-angle, dual-head detectors. present...
At present, in-beam positron emission tomography (PET) is the only method for in vivo and situ range verification ion therapy. GSI Helmholtzzentrum für Schwerionenforschung GmbH (GSI) Darmstadt, Germany, a unique PET installation has been operated from 1997 until shut down of carbon therapy facility 2008. Therapeutic irradiation by means (12)C beams more than 400 patients have monitored. In this paper first quantitative study on accuracy to detect deviations between planned applied treatment...
Therapeutic proton and heavier ion beams generate prompt gamma photons that may escape from the patient. In principle, this allows for real-time, in situ monitoring of treatment delivery, particular, hadron range within patient, by imaging emitted rays. Unfortunately, neutrons simultaneously created with create a background obscure signal. To enhance accuracy dose verification imaging, we therefore propose time-of-flight (TOF) technique to reject neutron background, involving shifting time...
The $\ensuremath{\gamma}$-ray strength function is an important input quantity for the determination of photoreaction rate and neutron capture astrophysics as well nuclear technologies. To test model predictions, photoabsorption cross section $^{139}\mathrm{La}$ up to neutron-separation energy was measured using bremsstrahlung produced at electron accelerator ELBE Forschungszentrum Dresden-Rossendorf with beam $11.5$ MeV kinetic energy. experimental data were analyzed by applying Monte Carlo...
Abstract We demonstrate the first ever recorded positron-emission tomography (PET) imaging and dosimetry of a FLASH proton beam at Proton Center MD Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with partial field view cylindrical poly-methyl methacrylate (PMMA) phantom irradiated beam. The had kinetic energy 75.8 MeV an intensity about 3.5 × 10 protons that extracted over 101.5 ms-long spills. radiation environment was...
Positron emission tomography (PET) is the imaging modality most extensively tested for treatment monitoring in particle therapy. Optimal use of PET proton therapy requires situ acquisition relatively strong (15)O signal due to its short half-life (~2 min) and high oxygen content biological tissues, enabling shorter scans that are less sensitive washout. This paper presents first performance tests a scaled-down time-of-flight (TOF) system based on digital photon counters (DPCs) coupled...
In-beam positron emission tomography (PET) is currently the only method for an in-situ monitoring of charged hadron therapy. However, in-beam PET data, measured at beams with a sub-/spl mu/s-microstructure due to accelerator radio frequency (RF), are highly corrupted by random coincidences arising from prompt /spl gamma/ rays following nuclear reactions as projectiles penetrate tissue. Since random-correction techniques conventional cannot be applied, clinical therapy facility Gesellschaft...
One of the long-standing problems in carbon-ion therapy is monitoring treatment, i.e. delivered dose to a given tissue volume within patient. Over last 8 years, in-beam positron emission tomography (PET) has been used at experimental carbon ion treatment facility Gesellschaft für Schwerionenforschung (GSI) Darmstadt and become valuable quality assurance tool.In order determine evaluate correct delivery patient dose, simulation emitter distribution compared measurement. particular effect...
At the experimental carbon ion treatment facility at Gesellschaft fur Schwerionenforschung (GSI) Darmstadt clinical benefit of in-beam PET method has been proven. It led to a significant improvement quality patient treatment. Several heavy facilities, which will provide in near future large variety ions, are planning or even under construction. The deduction clinically relevant parameters from data requires precise knowledge spatial distribution beam induced positron emitters irradiated...
Proton range monitoring may facilitate online adaptive proton therapy and improve treatment outcomes. Imaging of proton-induced prompt gamma (PG) rays using a knife-edge slit collimator is currently under investigation as potential tool for real-time monitoring. A major challenge in collimated PG imaging the suppression neutron-induced background counts. In this work, we present an initial performance test two camera prototypes based on arrays digital photon counters (DPCs). profiles emitted...
A single-bed, whole-body positron emission tomograph based on resistive plate chambers has been proposed (RPC-PET). An RPC-PET system with an axial field-of-view (AFOV) of 2.4 m shown in simulation to have higher sensitivity using the NEMA NU2-1994 protocol than commercial PET scanners. However, that does not correlate directly lesion detectability. The latter is better correlated planar (slice) sensitivity, obtained a NU2-2001 line-source phantom. After validation published data for GE...
We present imaging results of needle-like and planar22Na sources obtained with a prototype high-acceptance small-animal positron emission tomograph based on resistive plate chambers (RPC-PET). The maximum-likelihood expectation-maximization (MLEM) reconstruction the acquired data yielded an excellent stable resolution 0.4 mm FWHM.
The recently observed FLASH effect related to high doses delivered with rates has the potential revolutionize radiation cancer therapy if promising results are confirmed and an underlying mechanism understood. Comprehensive measurements essential elucidate phenomenon. We report first-ever demonstration of successive in-spill post-spill emissions gammas arising from irradiations by a proton beam. A small positron emission tomography (PET) system was exposed in ocular beam Proton Therapy...