A5000377815- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Radiation Effects in Electronics
- Advanced X-ray and CT Imaging
- Laser-Plasma Interactions and Diagnostics
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Boron Compounds in Chemistry
- Atomic and Subatomic Physics Research
- Radiomics and Machine Learning in Medical Imaging
- Particle Detector Development and Performance
- Nuclear reactor physics and engineering
- Laser-induced spectroscopy and plasma
- Photoacoustic and Ultrasonic Imaging
- Radiopharmaceutical Chemistry and Applications
- Gamma-ray bursts and supernovae
- Radiation Effects and Dosimetry
- High-pressure geophysics and materials
- Laser-Matter Interactions and Applications
- Particle accelerators and beam dynamics
- Laser Design and Applications
- Ion-surface interactions and analysis
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
2013-2024
German Cancer Research Center
2011-2024
Deutschen Konsortium für Translationale Krebsforschung
2022-2024
GSI Helmholtz Centre for Heavy Ion Research
2019-2024
MSB Medical School Berlin
2023
Metropolitan University
2021
Heidelberg University
2011-2020
University Hospital Heidelberg
2011-2020
Zero to Three
2020
We report on the development of open-source cross-platform radiation treatment planning toolkit matRad and its comparison against validated systems. The enables three-dimensional intensity-modulated therapy for photons, scanned protons carbon ions.matRad is entirely written in Matlab freely available online. It re-implements well-established algorithms employing a modular sequential software design to model entire workflow. comprises core functionalities import DICOM data, calculate optimize...
onte Carlo (MC) codes are increasingly spreading in the hadrontherapy community due to their detailed description of radiation transport and interaction with matter. The suitability a MC code for application demands accurate reliable physical models capable handling all components expected field. This becomes extremely important correctly performing not only but also biologically-based dose calculations, especially cases where ions heavier than protons involved. In addition, prediction...
Since the seventies, positron emission tomography (PET) has become an invaluable medical molecular imaging modality with unprecedented sensitivity at picomolar level, especially for cancer diagnosis and monitoring of its response to therapy.More recently, combination X-ray computed (CT) or magnetic resonance (MR) added high precision anatomic information in fused PET/CT PET/MR images, thus compensating modest intrinsic spatial resolution PET.Nevertheless, a number challenges call further...
The goal of this work was to facilitate the clinical use Monte Carlo proton dose calculation support routine treatment planning and delivery. code Geant4 used simulate head setup, including a time-dependent simulation modulator wheels (for broad beam modulation) magnetic field settings scanning). Any patient-field-specific setup can be modeled according control system facility. benchmarked against phantom measurements. Using ionization chamber reading in allows specified absolute units (Gy...
Our first in-beam PET measurements of the β+ activation induced by proton irradiation are presented. Monoenergetic beams in energy and intensity range suited for treatment deep-seated tumours were delivered synchrotron Gesellschaft für Schwerionenforschung Darmstadt (GSI). They stopped PMMA blocks placed centre field view positron camera that is installed heavy ion tumour facility at GSI. The activity signal was found to be three times larger than produced carbon ions same applied physical...
Reliable treatment planning of highly conformal scanned ion beam therapy demands accurate tools for the determination and characterization individual pencil-like beams building up integral dose delivery related mixed radiation field. At present, clinically practicable inverse systems (TPSs) can only rely on fast-performing analytical algorithms. However, rapidly emerging though more computationally intensive Monte Carlo (MC) methods be employed to complement TPS, e.g., via calculations input...
Clinical investigations on post-irradiation PET/CT (positron emission tomography/computed tomography) imaging for in vivo verification of treatment delivery and, particular, beam range proton therapy are underway at Massachusetts General Hospital (MGH). Within this project, we have developed a Monte Carlo framework CT-based calculation dose and irradiation-induced positron emitter distributions. Initial information is provided by separate Geant4 simulation modelling the head. Particle...
Purpose: Range verification in ion beam therapy relies to date on nuclear imaging techniques which require complex and costly detector systems. A different approach is the detection of thermoacoustic signals that are generated due localized energy loss beams tissue (ionoacoustics). Aim this work was study experimentally achievable position resolution ionoacoustics under idealized conditions using high frequency ultrasonic transducers a specifically selected probing beam. Methods: water...
Purpose: Intensity modulated proton therapy (IMPT) of head and neck (H&N) cancer patients may be improved by plan adaptation. The decision to adapt the treatment based on a dose recalculation current anatomy requires diagnostic quality computed tomography (CT) scan patient. As gantry‐mounted cone beam CT (CBCT) scanners are currently being offered vendors, they offer daily or weekly updates patient anatomy. CBCT image not sufficient for accurate calculation it is likely necessary perform...
To demonstrate a proof-of-concept for fast cone-beam CT (CBCT) intensity correction in projection space by the use of deep learning.The CBCT scans and corresponding projections were acquired from 30 prostate cancer patients. Reference shading was performed using validated method (CBCT cor ), which estimates scatter other low-frequency deviations measured on basis prior image obtained warping planning to CBCT. A convolutional neural network (ScatterNet) designed, consisting an attenuation...
Monte Carlo simulations play a crucial role for in-vivo treatment monitoring based on PET and prompt gamma imaging in proton carbon-ion therapies. The accuracy of the nuclear fragmentation models implemented these codes might affect quality verification. In this paper, we investigate GATE/Geant4 FLUKA by comparing angular energy distributions secondary particles exiting homogeneous target PMMA. Comparison results were restricted to 16O 12C. Despite very simple set-up, substantial...
An overview of progress and typical yields from intense laser-plasma acceleration ions is presented. The evolution laser-driven ion at relativistic intensities ushers prospects for improved functionality diverse applications which can represent a varied assortment beam requirements. This mandates the development integrated accelerator system, multiple components are described. Relevant high field science design controlled optimum pulsed laser irradiation on target dominant single shot...
Purpose This work aims at investigating intensity corrected cone‐beam x‐ray computed tomography (CBCT) images for accurate dose calculation in adaptive modulated proton therapy (IMPT) prostate and head neck (H&N) cancer. A deformable image registration (DIR)‐based method a scatter correction approach using the data obtained from DIR as prior are characterized compared on basis of same clinical patient cohort first time. Methods Planning CT (pCT) daily CBCT (reconstructed measured...
To assess image quality and to quantify the accuracy of relative electron densities (ρe ) effective atomic numbers (Zeff for three dual-energy computed tomography (DECT) scanners: a novel single-source split-filter (i.e., twin-beam) two dual-source scanners.Measurements were made with second generation scanner at 80/140Sn kVp, third-generation twin-beam 120 kVp gold (Au) tin (Sn) filters, 90/150Sn kVp. Three phantoms tissue inserts scanned used calibration validation parameterized methods...
In presence of inter-fractional anatomical changes, clinical benefits are anticipated from image-guided adaptive radiotherapy. Nowadays, cone-beam CT (CBCT) imaging is mostly utilized during pre-treatment for position verification. Due to various artifacts, image quality typically not sufficient photon or proton dose calculation, thus demanding accurate CBCT correction, as potentially provided by deep learning techniques. This work aimed at investigating the feasibility utilizing a...
In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, experiments have evidenced RBE dependencies on dose level, linear energy transfer (LET) and tissue type. This work compares the predictions three main radio-biological models proposed in literature by Carabe-Fernandez, Wedenberg, Scholz coworkers. Using chosen models, spread-out Bragg peak (SOBP) as well two exemplary clinical cases (single field fields) for cranial irradiation,...
In the field of radiotherapy, Monte Carlo (MC) particle transport calculations are recognized for their superior accuracy in predicting dose and fluence distributions patient geometries compared to analytical algorithms which generally used treatment planning due shorter execution times. this work, a newly developed MC-based (MCTP) tool proton therapy is proposed support studies research applications. It allows single-field simultaneous multiple-field optimization realistic scenarios based...
Purpose: Dual energy CT (DECT) has recently been proposed as an improvement over single (SECT) for stopping power ratio (SPR) estimation proton therapy treatment planning (TP), thereby potentially reducing range uncertainties. Published literature investigated phantoms. This study aims at performing TP on SECT and DECT head images of the same patients evaluating whether reported improved SPR accuracy translates into clinically relevant shifts in clinical scenarios. Methods: Two phantoms were...
Purpose: Modern facilities for actively scanned ion beam radiotherapy allow in principle the use of helium beams, which could present specific advantages, especially pediatric tumors. In order to assess potential these beams radiotherapy, i.e., create realistic treatment plans, authors set up a dedicated 4 He model, providing base data their planning system TRiP98, and they have reported that this work together with its physical biological validations. Methods: A semiempirical model depth...