A5044581050- Radiation Therapy and Dosimetry
- Laser-Plasma Interactions and Diagnostics
- Stellar, planetary, and galactic studies
- Astronomy and Astrophysical Research
- Advanced Radiotherapy Techniques
- Laser-induced spectroscopy and plasma
- Laser-Matter Interactions and Applications
- Advanced biosensing and bioanalysis techniques
- Astronomical Observations and Instrumentation
- Nuclear Physics and Applications
- RNA Interference and Gene Delivery
- High-pressure geophysics and materials
- Particle Detector Development and Performance
- Nanopore and Nanochannel Transport Studies
- Radiation Detection and Scintillator Technologies
- Advanced Fiber Laser Technologies
- Solid State Laser Technologies
- Photoacoustic and Ultrasonic Imaging
- Radiation Effects in Electronics
- Astrophysics and Star Formation Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced X-ray and CT Imaging
- Bacteriophages and microbial interactions
- Advancements in Photolithography Techniques
- Ultrasound and Hyperthermia Applications
Max Planck Institute of Biochemistry
2023-2024
Ludwig-Maximilians-Universität München
2011-2024
Center for NanoScience
2023-2024
Calar Alto Observatory
2014-2019
National Center for Oncological Hadrontherapy
2015
Klinikum rechts der Isar
2015
Max Planck Society
2009
Max Planck Institute of Quantum Optics
2009
Karlsruhe Institute of Technology
2007
This paper gives an overview of the CARMENES instrument and survey that will be carried out with it during first years operation. (Calar Alto high-Resolution search for M dwarfs Exoearths Near-infrared optical Echelle Spectrographs) is a next-generation radial-velocity under construction 3.5m telescope at Calar Observatory by consortium eleven Spanish German institutions. The scientific goal project conducting 600-night exoplanet targeting ~ 300 completed instrument. consists two separate...
Fluorescence microscopy, with its molecular specificity, is one of the major characterization methods used in life sciences to understand complex biological systems. Super-resolution approaches
Purpose: Range verification in ion beam therapy relies to date on nuclear imaging techniques which require complex and costly detector systems. A different approach is the detection of thermoacoustic signals that are generated due localized energy loss beams tissue (ionoacoustics). Aim this work was study experimentally achievable position resolution ionoacoustics under idealized conditions using high frequency ultrasonic transducers a specifically selected probing beam. Methods: water...
The new technology of laser-driven ion acceleration (LDA) has shown the potential for driving highly brilliant particle beams. Laser-driven differs from conventional proton sources by its ultra-high dose rate, whose radiobiological impact should be investigated thoroughly before adopting current clinical concepts. growth human FaDu tumors transplanted onto hind leg nude mice was measured sonographically. Tumors were irradiated with 20 Gy 23 MeV protons at pulsed mode single pulses 1 ns...
Spore-forming bacteria have two distinct division modes: sporulation and vegetative division. The placement of the foundational machinery component (Z-ring) within plane is contingent on mode. However, investigating if how performed differently between sporulating cells remains challenging, particularly at nanoscale. Here, we use DNA-PAINT super-resolution microscopy to compare 3D assembly distribution patterns key proteins SepF, ZapA, DivIVA, FtsZ. We determine that ZapA SepF mimics Z-ring...
Biological nanopores crucially control the import and export of biomolecules across lipid membranes in cells. They have found widespread use biophysics biotechnology, where their typically narrow, fixed diameters enable selective transport ions small molecules, as well DNA peptides for sequencing applications. Yet, due to channel sizes, they preclude passage large macromolecules, e.g., therapeutics. Here, unique combined properties origami nanotechnology, machine-inspired design, synthetic...
By frequency quadrupling a picosecond pulse train from Ti:sapphire laser at 820 nm we generate comb 205 with nearly bandwidth-limited pulses. The nonlinear conversion is accomplished by two successive doubling stages that take place in resonant cavities are matched to the repetition rate of 82 MHz. This allows for an overall efficiency 4.5 % and produces output power up 70 mW few minutes 25 continuous operation hours. Such deep UV may be employed direct spectroscopy cases where it less...
Dendritic cells (DCs) regulate immune priming by expressing programmed death ligand 1 (PD-L1) and PD-L2, which interact with the inhibitory receptor PD-1 on activated T cells. signaling regulates cell effector functions limits autoimmunity. Tumor can hijack this pathway overexpressing PD-L1 to suppress antitumor responses. Blocking has been beneficial for treatment of various cancer types, although only a subset patients responds. A deepened understanding spatial organization molecular...
We report on experimental studies of divergence proton beams from nanometer thick diamond-like carbon (DLC) foils irradiated by an intense laser with high contrast. Proton extremely small (half angle) 2 degree are observed in addition a remarkably well-collimated feature over the whole energy range, showing one order magnitude reduction angle comparison to results micrometer targets. demonstrate that this arises steep longitudinal electron density gradient and exponentially decaying...
Laser ion acceleration is an unique process that creates ultra-short pulses of high intensity ( > 107 ions/cm2/ns), which makes online detection ambitious task. Non-electronic detectors such as radio-chromic films (RCF), imaging plates (IP) or nuclear track (e.g. CR39) are broadly used at present. Only offline information on pulse and position available by these detectors, minutes to hours processing time required after their exposure. With increasing repetition rate the laser system, there...
Laser-driven accelerated (LDA) particle beams have due to the unique acceleration process very special properties. In particular they are created in ultra-short bunches of high intensity exceeding more than 107 per bunch. Characterization these is limited with conventional detectors. Non-electronic detectors such as imaging plates or nuclear track are, therefore, conventionally used at present. Moreover, all give only offline information about pulse position and require minutes hours be...
In environmental radiation monitoring, the time-variable natural gamma background complicates nuclide identification and analysis of a spectrum. A full spectrum based on noise adjusted singular value decomposition method for description adjustment calculations is possible method, which may provide advantages compared with peak-based analysis, if applied to time series spectra. An example shown discussed measured spectra obtained from spectroscopic detector NaI(Tl) scintillator as it used in...
Laser-accelerated proton beams exhibit remarkably different beam characteristics as compared to conventionally accelerated ion beams. About 105 107 particles per MeV and msr are quasi-instantaneously within about 1 ps. The resulting energy spectrum typically shows an exponentially decaying distribution. Our planned approach determine the of generated in each pulse is exploit time-of-flight (TOF) difference protons with kinetic energies at m distance from laser-target interaction. This...
ABSTRACT Biological nanopores crucially control the import and export of biomolecules across lipid membranes in cells. They have found widespread use biophysics biotechnology, where their typically narrow, fixed diameters enable selective transport ions small molecules as well DNA peptides for sequencing applications. Yet, due to channel sizes, they preclude passage large macromolecules, e.g., therapeutics. Here, we harness unique combined properties origami nanotechnology, machine-inspired...
Purpose: Many cell irradiation experiments with low‐energy laser‐driven ions rely on radiochromic films (RCF), because of their dose‐rate independent response and superior spatial resolution. RCF dosimetry in ion beams requires a correction the LET dependent film response. The relative efficiency (RE), ratio photon to proton dose that yields same darkening, is measure for film's dependence. A direct way RE determination mono‐energetic protons hence, well‐defined LET. However, usually...
Purpose: Range verification in ion beam therapy relies to date on nuclear imaging techniques which require complex and costly detector systems. A different approach is the detection of thermoacoustic signals that are generated due localized energy loss beams. Aim this work study feasibility determining range with sub‐mm accuracy by use high frequency ultrasonic (US) transducers image Bragg peak tomography. Methods: water phantom was irradiated a pulsed 20 MeV proton varying pulse intensity,...
Purpose: Laser-driven ion accelerators could be a future option for compact medical accelerator radiation therapy. Laser can deliver typical dose of few Gy in single pulse ns duration. Their rate, thus, exceeds the rate by several orders magnitude. Dosimetry at high repetition laser requires 2D dosimeters with dose-rate independent response. Both requirements fulfilled Gafchromic EBT2 or EBT3 films. Energies application accelerated ions (e.g. cell irradiation experiments) are still limited...
A PNCCD is successfully operating as one of the focal plane CCDs aboard satellite XMM-Newton. An advanced version this kind will be sensing devices for eROSITA X-ray astronomy mission. These fully depleted are developed and manufactured at MaxPlanck-Institute Semiconductor Lab together with company PNSensor. Their performance features make them useful in a variety measurement situations addition to astronomical ones. Applications range from photon detection (e.g. optical wave front sensors,...
S66ICTR-PHE 2016 quantification the proper attenuation, scatter and partial volume corrections need to be applied.If organ or lesion dosimetry is performed, precise determination of organ/lesion volumes necessary.Care has taken for an appropriate calibration imaging system. b) BiokineticsThis requires a correct temporal sampling use ad hoc procedures integrate activity within time obtain total number decays occurring in source organs thus time-integrated coefficients (TIACs). c) Absorbed...