A5016117668- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Advanced Optical Sensing Technologies
- CCD and CMOS Imaging Sensors
- Atomic and Subatomic Physics Research
- Particle Detector Development and Performance
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Analog and Mixed-Signal Circuit Design
- Dark Matter and Cosmic Phenomena
- Neutrino Physics Research
- Spacecraft Design and Technology
- Parallel Computing and Optimization Techniques
- Phase-change materials and chalcogenides
- Integrated Circuits and Semiconductor Failure Analysis
- Nuclear Physics and Applications
- Photonic and Optical Devices
- Cardiac Imaging and Diagnostics
- Optical Imaging and Spectroscopy Techniques
- Analytical Chemistry and Sensors
- Photocathodes and Microchannel Plates
- Advancements in PLL and VCO Technologies
- Advanced Fluorescence Microscopy Techniques
- Astrophysics and Cosmic Phenomena
- Microfluidic and Capillary Electrophoresis Applications
Université de Sherbrooke
2015-2024
Centre Hospitalier Universitaire de Sherbrooke
2016-2017
Brookhaven National Laboratory
2003-2012
Brigham and Women's Hospital
2010-2011
Stony Brook Medicine
2006-2007
Stony Brook University
2006
Since the seventies, positron emission tomography (PET) has become an invaluable medical molecular imaging modality with unprecedented sensitivity at picomolar level, especially for cancer diagnosis and monitoring of its response to therapy.More recently, combination X-ray computed (CT) or magnetic resonance (MR) added high precision anatomic information in fused PET/CT PET/MR images, thus compensating modest intrinsic spatial resolution PET.Nevertheless, a number challenges call further...
The next-generation Enriched Xenon Observatory (nEXO) is a proposed experiment to search for neutrinoless double beta ($0\nu\beta\beta$) decay in $^{136}$Xe with target half-life sensitivity of approximately $10^{28}$ years using $5\times10^3$ kg isotopically enriched liquid-xenon time projection chamber. This improvement two orders magnitude over current limits obtained by significant increase the mass, monolithic and homogeneous configuration active medium, multi-parameter measurements...
The projected performance and detector configuration of nEXO are described in this pre-Conceptual Design Report (pCDR). is a tonne-scale neutrinoless double beta ($0νββ$) decay search $^{136}$Xe, based on the ultra-low background liquid xenon technology validated by EXO-200. With $\simeq$ 5000 kg enriched to 90% isotope 136, has half-life sensitivity approximately $10^{28}$ years. This represents an improvement about two orders magnitude with respect current results. Based experience gained...
We developed a non-magnetic positron-emission tomography (PET) device based on the rat conscious animal PET that operates in small-animal magnetic resonance imaging (MRI) scanner, thereby enabling us to carry out simultaneous PET/MRI studies. The detector comprises 12 blocks, each being 4 × 8 array of lutetium oxyorthosilicate crystals (2.22 2.22 5 mm(3)) coupled matching avalanche photodiode array. housed plastic case, form 38 mm inner diameter ring with an 18 axial extent. Custom-built MRI...
Anesthesia is currently required for positron emission tomography (PET) studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects neurological state animal, complicating interpretation PET data. Furthermore, it precludes use study during normal behavior. The rat conscious tomograph (RatCAP) designed need studies. It a miniaturized full-ring scanner that attached directly head, imaging nearly entire brain. RatCAP utilizes arrays 2 mm /spl...
This paper presents a new quenching circuit (QC) and single photon avalanche diode (SPAD) implemented in TSMC CMOS 65 nm technology. The QC was optimized for timing resolution (SPTR) with view to an implementation 3D digital SiPM. presented has jitter of 4 ps full width at half maximum (FWHM) the SPAD 7.8 FWHM SPTR. adjustable threshold allows optimization as well excess voltage rise time characterization. threshold, hold-off recharge are essential optimize performances each SPAD. also...
Time-of-flight measurements are becoming essential to the advancement of several fields, such as preclinical positron emission tomography and high energy physics. Recent developments in single photon avalanche diode (SPAD)-based detectors have spawned a great interest digital silicon photomultipliers (dSiPMs). To overcome tradeoff between photosensitive area processing capabilities current 2-D dSiPM, we propose novel 3-D SiPM, where SPAD, designed for maximal area, will be stacked over...
Single Photon Avalanche Diodes (SPAD) are known for their excellent timing performance which enables Time of Flight capabilities in positron emission tomography (PET). However, current array architectures juxtapose the SPAD with its ancillary electronics at expense a poor fill factor array. The 3D vertical integration SPADs and readout represents solution to aforementioned problem. Compared systems external readout, reduces interconnect parasitic capacitance while greatly increasing...
Contemporary positron emission tomography (PET) scanners are commonly implemented with very large scale integration analog front-end electronics to reduce power consumption, space, noise, and cost. Analog processing yields excellent results in dedicated applications, but offers little flexibility for sophisticated signal or more accurate measurements newer, fast scintillation crystals. Design goals of the new Sherbrooke PET/computed (CT) scanner are: 1) achieve 1 mm resolution both...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The RatCAP has been designed and constructed to image the awake rat brain. In order maximize system performance, offline digital coincidence data processing algorithms including offset delay correction prompt delayed detection have developed validated. With using a singular value decomposition (SVD) technique, overall time resolution was improved from 32.6 17.6 ns FWHM. experimental results...
The LabPET II detector block was designed to achieve submillimeter spatial resolution in small animal PET imaging. Each detection consists of two arrays 4 × 8 avalanche photodiodes (APD) individually coupled an scintillator array, form 64 independent detectors with parallel readout channels. This new entails eightfold increase pixel density compared the I. A 64-channel mixed-signal application-specific integrated circuit (ASIC) extract relevant data real time from blocks. In order interface...
The 3D vertical integration of SPAD and readout electronics is a promising avenue to high performance photodetectors. This approach will minimize most limitations current SiPM lead better performances in terms effective PDE, timing added functionalities. In this paper, we present new integrated digital electronic architecture. specific architecture aims replace conventional analog with the benefits significantly lower constant output capacitance as well immunity gain variation on single...
The CMOS 0.18-/spl mu/m technology was investigated for two analog front-end projects: the low-power budget rat-head mounted miniature rat conscious animal PET (RatCAP) scanner, and high-performance, low-noise, high-rate PET/CT application. first VLSI prototypes consisted of 1- 5-mW charge sensitive preamplifiers (CSP) based on a modified cascode telescopic architecture. Characterization rise time, linearity, dynamic range, equivalent noise (ENC), timing resolution energy are reported...
At Brookhaven National Laboratory, we are developing a simultaneous PET-MRI breast imaging system. A prototype II version of the PET system has been constructed. This device consists 24 detector blocks where each block 4 × 8 array 2.2 15 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> LYSO crystal directly coupled to non-magnetic APD array. The scanner an inner diameter 100 and axial extent 18 mm. Resolution measurements were carried...
We developed a configurable model of single photon avalanche diodes (SPAD) array photodetectors with intelligent control and active quenching. In this individual components can be simulated independently subsequently linked to provide the overall detector response. The enables simulation entire analysis performance, including detection efficiency, timing energy resolution. It used optimize performance for specific applications, such as positron emission tomography (PET). simulator consists...
Single photon avalanche diode (SPAD) arrays have proven themselves as serious candidates for time of flight positron emission tomography (PET). Discrete readout schemes mitigate the low-noise requirements analog and offer very fine control over threshold levels timing pickup strategies. A high optical fill factor is paramount to performance in such detectors, consequently space limited closely integrated electronics. Nonetheless, a production, daily used PET scanner must minimize bandwidth...
Abstract A new trend in large area noble liquid experiments is to measure the scintillation light with photodetectors and their electronics inside active volume. Compared typical approach of using silicon photomultipliers (SiPM) an analog readout chain leading analog-to-digital converter, this paper presents a 3D photon-to-digital converter (PDC) that takes advantage binary nature single-photon avalanche diodes (SPAD). The contains 4096 pixels over 25 mm 2 , each including bonding pad...
We report on the development of front-end electronics for rat conscious animal positron emission tomography (RatCAP), a portable and miniature scanner. The application-specific integrated circuit (ASIC) is realized in complementary metal-oxide-semiconductor 0.18 /spl mu/m technology composed 32 channels charge sensitive preamplifier, third-order semi-Gaussian bipolar shaper, timing discriminator with independent channel adjustable threshold, 32-line address serial encoder to minimize number...
One of the most challenging and potentially rewarding research applications PET is imaging mouse brain. Although very high spatial resolution required (< ~1 mm), there a much wider variety transgenic models in compared to rat. The solid state material CdZnTe (CZT) has long held promise for PET. Compared scintillators, its limitations time sensitivity can some ways be compensated by extremely energy resolution, compact geometry, sophisticated data processing techniques. Using such techniques,...
The ability to acquire high resolution anatomical data as well quantitative functional information in vivo is becoming an increasingly important factor the diagnosis of disease. Simultaneous acquisition PET and MRI would provide essentially perfect co-registration between two images which particularly for tissues whose position shape can change sequential scans. RatCAP a complete 3D tomograph that designed image brain awake rat. A special coil composed 2 saddle elements working quadrature...