A5055398194- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced X-ray and CT Imaging
- Radiation Detection and Scintillator Technologies
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Analog and Mixed-Signal Circuit Design
- Cardiac Imaging and Diagnostics
- CCD and CMOS Imaging Sensors
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Radiopharmaceutical Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Particle Detector Development and Performance
- Neuroendocrine regulation and behavior
- Cell Image Analysis Techniques
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Radioactive Decay and Measurement Techniques
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
Eli Lilly (United States)
2017-2023
Brigham and Women's Hospital
2010-2012
Harvard University
2011-2012
Stony Brook University
2005-2011
Brookhaven National Laboratory
2005-2011
State University of New York
2007-2008
RIKEN BNL Research Center
2008
Importance Positron emission tomography (PET) may increase the diagnostic accuracy and confirm underlying neuropathologic changes of Alzheimer disease (AD). Objective To determine antemortem [ 18 F]flortaucipir PET images for predicting presence AD-type tau pathology at autopsy. Design, Setting, Participants This study (A16 primary cohort) was conducted from October 2015 to June 2018 28 sites (27 in US 1 Australia). Individuals with a terminal illness who were older than 50 years had...
The advent of tau-targeted PET tracers such as flortaucipir (18F) (flortaucipir, also known 18F-AV-1451 or 18F-T807) have made it possible to investigate the sequence development tau in relationship age, amyloid-β, and cognitive impairment due Alzheimer's disease. Here we report a multicentre longitudinal evaluation relationships between baseline tau, change change, using imaging. A total 202 participants 50 years old older, including 57 cognitively normal subjects, 97 clinically defined...
We developed a non-magnetic positron-emission tomography (PET) device based on the rat conscious animal PET that operates in small-animal magnetic resonance imaging (MRI) scanner, thereby enabling us to carry out simultaneous PET/MRI studies. The detector comprises 12 blocks, each being 4 × 8 array of lutetium oxyorthosilicate crystals (2.22 2.22 5 mm(3)) coupled matching avalanche photodiode array. housed plastic case, form 38 mm inner diameter ring with an 18 axial extent. Custom-built MRI...
PET imaging of tau pathology in Alzheimer disease may benefit from the use white matter reference regions. These regions have shown reduced variability compared with conventional cerebellar amyloid imaging. However, they are susceptible to contamination partial-volume blurring tracer uptake cortex. We present a new technique, PERSI (Parametric Estimation Reference Signal Intensity), for flortaucipir F 18 count normalization that leverages advantages while mitigating potential effects....
Alzheimer disease (AD) is characterized by β-amyloid (Aβ) plaques and tau neurofibrillary tangles. There are several PET imaging biomarkers for Aβ including 11C-PiB 18F-florbetapir. Recently, tracers tangles have become available shown utility in detection monitoring of pathology over time. Flortaucipir F 18 one such tracer. Initial clinical studies indicated greater binding AD mild cognitive impairment patients than controls a pattern consistent with observed at autopsy. However, little...
It has been proposed that the signal distribution on tau positron emission tomography (PET) images could be used to define pathologic stages similar those seen in neuropathology.
Abstract Background There is an increasing interest in utilizing tau PET to identify patients early Alzheimer’s disease (AD). In this work, a temporal lobe composite ( Eτ ) volume of (VOI) was evaluated longitudinal flortaucipir cohort and compared previously described global neocortical VOI. separate autopsy-confirmed study, the sensitivity VOI for identifying intermediate (B2) neurofibrillary tangle (NFT) pathology evaluated. Methods A total 427 subjects received flortaucipir, florbetapir,...
Tau neurofibrillary tangle burden increases with Alzheimer's disease (AD) stage and correlates degree of cognitive impairment. PET imaging could facilitate understanding the relationship between tau pathology Evaluate 18F flortaucipir uptake patterns cognition across multiple domains. We acquired scans in 84 amyloid-positive control, mild impairment (MCI), AD subjects. Flortaucipir standardized value ratio (SUVr) values were obtained from a neocortical volume interest (VOI), precuneus VOI,...
At autopsy, individuals with Alzheimer’s disease (AD) exhibit heterogeneity in the distribution of neurofibrillary tangles neocortical and hippocampal regions. Subtypes AD, defined using an algorithm based on relative number tangle counts these regions, have been proposed—hippocampal sparing (relative hippocampus but high cortical load), limbic predominant (high load lower association cortices), typical (balanced cortices) AD—and shown to be associated distinct antemortem clinical...
Alzheimer's disease (AD) is characterized by the presence of both amyloid and tau pathology. In vivo diagnosis can be made with positron emission tomography (PET) imaging. Emergent evidence supports that accumulation are associated may precede tau. This report further investigates relationship between to assess whether elevated cortical predict in participants early symptomatic AD.Florbetapir F18 flortaucipir uptake were evaluated from baseline PET scans collected three multi-center studies...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The RatCAP has been designed and constructed to image the awake rat brain. In order maximize system performance, offline digital coincidence data processing algorithms including offset delay correction prompt delayed detection have developed validated. With using a singular value decomposition (SVD) technique, overall time resolution was improved from 32.6 17.6 ns FWHM. experimental results...
At Brookhaven National Laboratory, we are developing a simultaneous PET-MRI breast imaging system. A prototype II version of the PET system has been constructed. This device consists 24 detector blocks where each block 4 × 8 array 2.2 15 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> LYSO crystal directly coupled to non-magnetic APD array. The scanner an inner diameter 100 and axial extent 18 mm. Resolution measurements were carried...
We have developed a new method of compensating for effects partial volume and spillover in dual-modality imaging. The approach requires segmentation just few tissue types within small volume-of-interest (VOI) surrounding lesion; the algorithm estimates simultaneously, from projection data, activity concentration each segmented inside VOI. Measured emission projections were fitted to sum resolution-blurred such tissue, scaled by its unknown concentration, plus global background contribution...
The ability to acquire high resolution anatomical data as well quantitative functional information in vivo is becoming an increasingly important factor the diagnosis of disease. Simultaneous acquisition PET and MRI would provide essentially perfect co-registration between two images which particularly for tissues whose position shape can change sequential scans. RatCAP a complete 3D tomograph that designed image brain awake rat. A special coil composed 2 saddle elements working quadrature...
RatCAP (Rat Conscious Animal PET) is miniature positron emission tomography scanner intended for neurological and behavioral study of small awake animal. The system comprises three distinct modules: rigid-flex technology based Printed Circuit Board (PCB) which houses the detector components front end Application Specific Integrated (ASIC), Time to Digital Converter Signal Processing module (TSPM) receives processes ASIC signals transmits processed data over two Giga bit fiber optic links PCI...
Obtaining the best possible task performance using reconstructed SPECT images requires optimization of both collimator and reconstruction parameters. The goal this study is to determine how perform optimization, namely whether parameters can be optimized solely from projection data, or should also considered. In order answer question, optimal collimation, a digital phantom representing human torso with 16 mm diameter hot lesions (activity ratio 8:1) was generated used simulate clinical...
This work describes a fully 3D statistical image reconstruction for the RatCAP (Rat Conscious Animal PET) using Monte Carlo based system matrix. The consists of 12 Iutetium oxyorthosilicate (LSO)-avalanche photodiode (APD) detector blocks arranged in ring 41.2 mm diameter. Due to small diameter and low number total lines response (LORs), size complete matrix is comparison typical animal scanner. allows incorporation an accurate, RatCAP-specific physical model with inclusion crystal...
We propose to develop a high resolution scanner for simultaneous PET and MRI breast imaging that is capable of providing highly sensitive specific cancer examinations. The addition positron emission tomography capability an existing dedicated system will give device in which each the modalities contributes its strengths compensate weaknesses other. In this combined modality scanner, we have anatomical information from somewhat poorer PET, predictive power identifying type lesion overcome...
A new method of compensating for tissue-fraction and count-spillover effects, which require tissue segmentation only within a small volume surrounding the primary lesion interest, was evaluated SPECT imaging. Tissue-activity concentration estimates are obtained by fitting measured projection data to statistical model segmented projections. Multiple realizations two simulated human-torso phantoms, each containing 20 spherical 'tumours', 1.6 cm in diameter, with tumour-to-background ratios 8:1...
The original prototype RatCAP PET scanner for conscious rat brain imaging has undergone a redesign of most major components resulting in distinct 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> -generation instrument. While maintaining the same field view (38 mm diameter, 18 axial) and similar overall architecture, new design allows longer crystals to provide approximately factor increase coincidence sensitivity with minimal size...
We are developing a scanner that will allow the simultaneous acquisition of high resolution anatomical data using Magnetic Resonance Imaging (MRI) and quantitative physiological Positron Emission Tomography (PET). The approach is based on technology used for RatCAP conscious small animal PET tomograph which utilizes block detectors consisting pixelated arrays LSO crystals read out with matching avalanche photodiodes (APDs) custom-designed ASIC. A version detector being developed be...
Kinetic modeling permits quantification of radiotracer dynamics in tissue by using the amount radioactivity blood as an input function to a kinetic model. This usually requires obtaining multiple samples during dynamic PET scans. As this procedure is considered health risk for patient and medical personnel, wrist scanner has been devised that can be used obtain with minimum discomfort without drawing arterial blood. A prototype two detector pairs evaluated. The spatial resolution,...