A5062484236- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Cancer Immunotherapy and Biomarkers
- Neural and Behavioral Psychology Studies
- CAR-T cell therapy research
- Medical Imaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Diet and metabolism studies
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Cancer Cells and Metastasis
- Thyroid Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Attention Deficit Hyperactivity Disorder
- Neonatal Respiratory Health Research
- Mental Health Research Topics
- Preterm Birth and Chorioamnionitis
- Neuroscience, Education and Cognitive Function
- Neural dynamics and brain function
- Neonatal and Maternal Infections
- Peptidase Inhibition and Analysis
University Hospital Regensburg
2015-2024
Boğaziçi University
1999-2024
Center for Life Sciences
2024
German Red Cross
2020
University of Regensburg
2018-2019
Yeditepe University
2016-2018
Brookhaven National Laboratory
2007-2014
Stony Brook University
2011-2014
Heinrich Heine University Düsseldorf
2000-2013
State University of New York
2013
We developed a non-magnetic positron-emission tomography (PET) device based on the rat conscious animal PET that operates in small-animal magnetic resonance imaging (MRI) scanner, thereby enabling us to carry out simultaneous PET/MRI studies. The detector comprises 12 blocks, each being 4 × 8 array of lutetium oxyorthosilicate crystals (2.22 2.22 5 mm(3)) coupled matching avalanche photodiode array. housed plastic case, form 38 mm inner diameter ring with an 18 axial extent. Custom-built MRI...
Uncontrollable stress can have a profound effect on an organism's ability to respond effectively future stressful situations. Behavior subsequent uncontrollable vary greatly between individuals, falling spectrum healthy resilience and maladaptive learned helplessness. It is unclear whether dysfunctional brain activity during associated with vulnerability helplessness; therefore, we measured metabolic that correlated ensuing inability escape stressors. We took advantage of small animal...
Abstract Transforming growth factor β (TGFβ) is a major component of tumor‐derived small extracellular vesicles (TEX) in cancer patients. Mechanisms utilized by TGFβ + TEX to promote tumor and pro‐tumor activities the microenvironment (TME) are largely unknown. produced head neck squamous cell carcinoma (HNSCC) lines carried angiogenesis‐promoting proteins. stimulated macrophage chemotaxis without notable M1/M2 phenotype shift reprogrammed primary human macrophages pro‐angiogenic...
The programmed cell death protein-1 (PD-1)/programmed ligand-1 (PD-L1) axis blockade has been implemented in advanced-stage tumor therapy for various entities, including head and neck squamous carcinoma (HNSCC). Despite a promising response subgroup of HNSCC patients, the majority suffer from disease progression. PD-L1 is known to influence several intrinsic mechanisms cancer cells, such as proliferation, apoptosis, migration invasion. Here, we modulated expression three lines with...
Multiple lines of evidence suggest that disturbances in excitatory transmission contribute to depression. Whether these defects involve the number, size, or composition glutamatergic contacts is unclear. This study used recently introduced procedures for fluorescence deconvolution tomography a well-studied rat model congenital depression characterize synapses layer I infralimbic cortex, region involved mood disorders, and primary somatosensory cortex. Three groups were studied: (1) rats bred...
In 28- to 30-month-old rats, in vitro short-term and long-term potentiation (STP LTP) were measured area CA1 of the hippocampus seven superior inferior learners, that selected from a pool 40 rats based on water maze escape performance over period 9 days. The aim was examine whether levels STP LTP could account for group differences learning escape, spatial preference wall (thigmotaxis)-avoidance retention an inhibitory avoidance task. There no significant difference open-field exploration,...
At present, targeting PD-1/PD-L1 axis for immune checkpoint inhibition has improved treatment of various tumor entities, including head and neck squamous cell carcinoma (HNSCC). However, one part the patient cohort still shows little improvement or even hyperprogression. We established three radioresistant (RR) radiosensitive (RS) HNSCC lines. RR cells showed prolonged survival as well delayed diminished apoptosis after irradiation with vimentin expression but no E-cadherin expression,...
Individual differences in water maze and open-field performance of aged adult rats were compared a cross-sectional study. Three- 24-month-old classified into superior, moderate, inferior groups on the basis escape latencies during hidden platform acquisition regarding extinction, behavior. Unexpectedly, subgroup invariant across age: The superior learners differed (a) thigmotactic swimming extinction (b) rearings. Thus, although aging has detrimental effect degree impairment might be partly...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a global cancer burden with 5‐year overall survival rate of around 50%, stagnant for decades. A tumour‐induced immunosuppressive microenvironment contributes to HNSCC progression, the adenosine (ADO) pathway an upregulated expression inhibitory immune checkpoint regulators playing key role in this context. The correlation between high neutrophil‐to‐lymphocyte ratio (NLR) advanced tumour staging suggests involvement neutrophils (NØ)...