A5049743547- Particle Detector Development and Performance
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- CCD and CMOS Imaging Sensors
- Advanced MRI Techniques and Applications
- Advancements in Semiconductor Devices and Circuit Design
- Diamond and Carbon-based Materials Research
- Semiconductor materials and devices
- Atomic and Subatomic Physics Research
- Radiation Effects in Electronics
- Advanced Radiotherapy Techniques
- Photonic and Optical Devices
- Advanced Semiconductor Detectors and Materials
- Infrared Target Detection Methodologies
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Anesthesia and Pain Management
- Advanced X-ray and CT Imaging
- Advanced NMR Techniques and Applications
- Photocathodes and Microchannel Plates
- Advanced Neuroimaging Techniques and Applications
- Advanced Optical Sensing Technologies
- Radio Frequency Integrated Circuit Design
- Neurological Disease Mechanisms and Treatments
- Digital Radiography and Breast Imaging
The Ohio State University
2010-2024
University of British Columbia
2024
Texas Tech University Health Sciences Center
2024
Texas Tech University
2024
Western University
2022-2024
University of Alberta
2024
University of Calgary
2024
George Washington University
2021-2023
Brookhaven National Laboratory
1980-2018
Johns Hopkins University
2017
The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, therapeutic purposes. We describe a metabolic biomarker the detection quantification NPCs human vivo. used proton nuclear magnetic resonance spectroscopy to identify characterize which are enriched demonstrated its use as reference monitoring neurogenesis. To detect low concentrations vivo, we developed signal processing method that enabled...
We developed a non-magnetic positron-emission tomography (PET) device based on the rat conscious animal PET that operates in small-animal magnetic resonance imaging (MRI) scanner, thereby enabling us to carry out simultaneous PET/MRI studies. The detector comprises 12 blocks, each being 4 × 8 array of lutetium oxyorthosilicate crystals (2.22 2.22 5 mm(3)) coupled matching avalanche photodiode array. housed plastic case, form 38 mm inner diameter ring with an 18 axial extent. Custom-built MRI...
Development of noninvasive techniques to discover new biomarkers in the live brain is important further understand underlying metabolic pathways significance for processes such as anesthesia-induced apoptosis and cognitive dysfunction observed undeveloped brain. We used vivo proton magnetic resonance spectroscopy two different signal processing approaches test hypothesis that volatile (isoflurane) intravenous (propofol) anesthetics at equipotent doses produce distinct metabolomic profiles...
Ischemic stroke triggers a massive, although transient, glutamate efflux and excessive activation of NMDA receptors (NMDARs), possibly leading to neuronal death. However, multiple clinical trials with antagonists failed improve, or even worsened, outcome. Recent findings persistent post-stroke decline in NMDAR density, which plays pivotal role plasticity memory formation, suggest that stimulation, rather than inhibition, may prove beneficial the subacute period after stroke. AIM: This study...
Dual-modality imaging, using Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) simultaneously, is a powerful tool to gain valuable information correlating structure with function in biomedicine. The advantage of this dual approach that the strengths one modality can balance weaknesses other. However, success technique requires developing imaging probes suitable for both. Here, we report on development nanoparticle labeling procedure via covalent bonding carbon-11 PET...
Lidocaine can alleviate acute as well chronic neuropathic pain at very low plasma concentrations in humans and laboratory animals. The mechanism(s) underlying lidocaine's analgesic effect when administered systemically is poorly understood but clearly not related to interruption of peripheral nerve conduction. Other targets for action(s) have been suggested, including sodium channels other receptor sites the central rather than nervous system. To our knowledge, lidocaine on brain's...
This article presents the design and implementation of a radiation-hardened analog front-end (AFE) integrated circuit (IC) developed for interfacing with solid state ionizing radiation detectors, providing accurate amplitude time-of-arrival measurements. The AFE is designed use in Beam Conditions Monitor Prime (BCM') ATLAS experiment at Large Hadron Collider (LHC). proposed comprised four channels, allowing re-configuration to operate as either low-noise high-gain amplifier beam luminosity...
We previously integrated a magnetic resonance-(MR-) compatible small-animal positron emission tomograph (PET) in Bruker 9.4 T microMRI system to obtain simultaneous PET/MR images of rat's brain and gated mouse-heart. To minimize electromagnetic interactions our MR-PET system, viz., the effect radiofrequency (RF) pulses on PET, we tested modular front-end PET electronics with various shield configurations, including solid aluminum one thin segmented layers copper. noted that gradient-echo RF...
Rationale Dividing cells can be detected in the live brain by positron emission tomography or optical imaging. Here we apply proton magnetic resonance spectroscopy (1HMRS) and a widely used spectral fitting algorithm to characterize effect of increased neurogenesis after electroconvulsive shock rodent via signatures representing mobile lipids resonating at ∼1.30 ppm. In addition, also same 1HMRS methodology metabolically profile glioblastomas with actively dividing growing RCAS-PDGF mice....
Rationale Vasoactive Intestinal Peptide (VIP), a pulmonary vasodilator and inhibitor of vascular smooth muscle proliferation, is absent in arteries patients with idiopathic arterial hypertension (PAH). We previously determined that targeted deletion the VIP gene mice leads to PAH remodeling right ventricular (RV) dilatation. Whether left ventricle also affected by unknown. In current study, we examined if knockout (VIP−/−) develop both (LV) cardiomyopathy, manifested LV dilatation systolic...
<h3><b>Summary</b></h3> In Canada, trauma patients often present initially to non-trauma hospitals without vascular surgeons on site. Local need skills and support for damage-control surgery. Canadian training programs in general surgery should equip trainees with this area, including resuscitation, identification of injury, hemorrhage control, temporizing measures (e.g., shunts, ligation). Caring is a multidisciplinary endeavour; understanding local/regional skill sets from whom seek help...
Background: Hybrid positron emission tomography (PET)-magnetic resonance imaging (MRI) systems have been taken in use as new clinical diagnostic tools including detection and therapy planning of cancer. To reduce the amount contrast agents injected patients while fully benefitting both modalities, dual-modality probes are required. Material methods: This study was first aimed at developing a hybrid PET-MRI probe by labeling superparamagnetic iron oxide nanoparticles (SPIONs) with 64Cu using...
This article presents a detailed analysis of the impact tank feedline on tuning range (TR) and phase noise (PN) in millimeter-wave <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</i> voltage-controlled oscillators (VCOs). A robust extended TR design, with low PN small die area, is later proposed, analyzed, experimentally validated. new interconnect approach for coarse capacitor bank used to significantly reduce routing capacitance...