A5008735072- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Nuclear physics research studies
- Advanced MRI Techniques and Applications
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Astronomical and nuclear sciences
- Atomic and Molecular Physics
- Advanced X-ray and CT Imaging
- Rare-earth and actinide compounds
- Radiopharmaceutical Chemistry and Applications
- CCD and CMOS Imaging Sensors
- Analog and Mixed-Signal Circuit Design
- Radiomics and Machine Learning in Medical Imaging
- Advanced Chemical Physics Studies
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Radiation Therapy and Dosimetry
- Advanced NMR Techniques and Applications
- Particle Detector Development and Performance
- Lanthanide and Transition Metal Complexes
- Cardiac Imaging and Diagnostics
- Advanced Radiotherapy Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Parkinson's Disease Mechanisms and Treatments
Stony Brook University
2014-2025
Renaissance University
2024
Stony Brook School
2019-2023
Stony Brook Medicine
2019-2022
Brookhaven National Laboratory
2006-2018
Université de Sherbrooke
2009
State University of New York
1987-2005
University of York
1994-1996
University of Liverpool
1992-1996
McMaster University
1993-1996
The reinforcing effects of drugs abuse result from the complex interaction between pharmacological and conditioned responses. Here we evaluate how expectation affects response to stimulant drug methylphenidate in 25 cocaine abusers. (0.5 mg/kg, i.v.) on brain glucose metabolism (measured by [18F]deoxyglucose-positron emission tomography) its (self-reports effects) were evaluated four conditions: (1) expecting placebo receiving placebo; (2) methylphenidate; (3) (4) placebo. Methylphenidate...
Methylphenidate is the most commonly prescribed drug for attention deficit hyperactivity disorder (ADHD), yet its therapeutic mechanisms are poorly understood. The objective of this study was to assess if methylphenidate, by increasing dopamine (neurotransmitter involved in motivation) brain, would enhance saliency an academic task, making it more interesting.Healthy subjects (N=16) underwent positron emission tomography with [(11)C]raclopride (dopamine D(2) receptor radioligand that...
We developed a non-magnetic positron-emission tomography (PET) device based on the rat conscious animal PET that operates in small-animal magnetic resonance imaging (MRI) scanner, thereby enabling us to carry out simultaneous PET/MRI studies. The detector comprises 12 blocks, each being 4 × 8 array of lutetium oxyorthosilicate crystals (2.22 2.22 5 mm(3)) coupled matching avalanche photodiode array. housed plastic case, form 38 mm inner diameter ring with an 18 axial extent. Custom-built MRI...
Anesthesia is currently required for positron emission tomography (PET) studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects neurological state animal, complicating interpretation PET data. Furthermore, it precludes use study during normal behavior. The rat conscious tomograph (RatCAP) designed need studies. It a miniaturized full-ring scanner that attached directly head, imaging nearly entire brain. RatCAP utilizes arrays 2 mm /spl...
The evolution of flight is a rare event in vertebrate history, and one that demands functional integration across multiple anatomical/physiological systems. neuroanatomical basis for such the role brain assumes behavioural transformations remain poorly understood. We make progress by (i) generating positron emission tomography (PET)-based map activity pigeons during rest flight, (ii) using these maps analysis (iii) interpreting data within macroevolutionary context shaped non-avian...
One of the major mechanisms for terminating actions catecholamines and vasoactive dietary amines is oxidation by monoamine oxidase (MAO). Smokers have been shown to reduced levels brain MAO, leading speculation that MAO inhibition tobacco smoke may underlie some behavioral epidemiological features smoking. Because smoking exposes peripheral organs as well MAO-inhibitory compounds, we questioned whether smokers would also in organs. Here compared B nonsmokers using positron emission...
High-spin states in the odd-proton $^{119,121}\mathrm{I}$ isotopes have been studied following heavy-ion fusion-evaporation reactions using boron and carbon beams. Both prolate (\ensuremath{\gamma}=0\ifmmode^\circ\else\textdegree\fi{}) oblate (\ensuremath{\gamma}=-60\ifmmode^\circ\else\textdegree\fi{}) collective bands observed built on low-lying positive- negative-parity proton states, namely, ${\mathit{h}}_{11/2}$, ${\mathit{g}}_{9/2}$, ${\mathit{g}}_{7/2}$, ${\mathit{d}}_{5/2}$ orbitals....
Excited states have been populated in ${}^{108}\mathrm{In}$ and ${}^{110}\mathrm{In}$ complementary backed- thin-target experiments using the Stony Brook $8\ensuremath{\pi}\mathrm{Ge}$-detector arrays. The level schemes for both isotopes extended modified, including first observation of $\ensuremath{\Delta}I=2$ bands ${}^{110}\mathrm{In}.$ Lifetimes four $\ensuremath{\Delta}I=1$ one band measured Doppler-shift attenuation method. Experimental total angular momenta reduced transition...
Three rotational bands have been discovered in the nucleus $^{109}\mathrm{Sb}$ that extend angular momentum to \ensuremath{\simeq}81/2\ensuremath{\Elzxh}. The frequency at highest spins reaches \ensuremath{\Elzxh}\ensuremath{\omega}\ensuremath{\simeq}1.4 MeV, so far observed a heavy nucleus. With increasing collective moments of inertia all three smoothly diminish unexpectedly low values, ${\mathit{scrJ}}^{(2)}$\ensuremath{\sim}13${\mathrm{\ensuremath{\Elzxh}}}^{2}$...
Three decoupled (\ensuremath{\Delta}I=2) rotational bands have been observed to rise out of irregular spherical excitations in $_{51}^{117}\mathrm{Sb}$ at moderate spin. These are interpreted as resulting from low-lying \ensuremath{\pi}${\mathit{g}}_{7/2}$, \ensuremath{\pi}${\mathrm{d}}_{5/2}$, and \ensuremath{\pi}${\mathit{h}}_{11/2}$ valence orbitals outside the Z=50 closed shell coupled deformed...
The methamphetamine molecule has a chiral center and exists as 2 enantiomers, d-methamphetamine (the more active enantiomer) l-methamphetamine less enantiomer). d-Methamphetamine is associated with intense stimulant effects higher abuse liability. objective of this study was to measure the pharmacokinetics for comparison both (-)-cocaine in baboon brain peripheral organs assess saturability pharmacologic specificity binding.d- were labeled (11)C via alkylation norprecursors (11)C-methyl...
Spatial resolution in positron emission tomography using traditional pixelated block detectors is inherently limited by the size of detector array elements, namely, scintillator crystals and readout pixels. Conventional centroiding algorithms based on Anger logic are widely used to localize individual events down level. However, these associated with well-known performance degradation along edges corners arrays. In this article, we explore use convolutional neural networks (CNNs) for 3D...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The RatCAP has been designed and constructed to image the awake rat brain. In order maximize system performance, offline digital coincidence data processing algorithms including offset delay correction prompt delayed detection have developed validated. With using a singular value decomposition (SVD) technique, overall time resolution was improved from 32.6 17.6 ns FWHM. experimental results...
Two weakly populated rotational bands have been established in $^{106}\mathrm{Sn}$ from the $^{54}\mathrm{Fe}$ ${(}^{58}$Ni,\ensuremath{\alpha}2p) reaction at 243 MeV. One of shows evidence termination. The result is consistent with cranked Nilsson model calculations, which predict band terminations a smooth and gradual shape change prolate collective to an oblate noncollective structure.
Intruder rotational bands have been investigated to high frequency in $_{51}^{109}\mathrm{Sb}$. Five decoupled (\ensuremath{\Delta}I=2) extending frequencies above 1.4 MeV/\ensuremath{\Elzxh} observed. At the highest frequencies, ${\mathit{J}}^{(2)}$ dynamic moments of inertia for four these are seen decrease steadily unexpectedly low values, \ensuremath{\sim} 10 ${\mathrm{\ensuremath{\Elzxh}}}^{2}$ ${\mathrm{MeV}}^{\mathrm{\ensuremath{-}}1}$. These bands, which interpreted as being based on...