A5057328085- Complex Systems and Time Series Analysis
- Colorectal Cancer Screening and Detection
- Statistical Methods in Clinical Trials
- Optimal Experimental Design Methods
- AI in cancer detection
- Market Dynamics and Volatility
- Gut microbiota and health
- Neurotransmitter Receptor Influence on Behavior
- Inflammatory Bowel Disease
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Microscopic Colitis
- Platelet Disorders and Treatments
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Medical Image Segmentation Techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Advanced Proteomics Techniques and Applications
- Image Retrieval and Classification Techniques
- Financial Risk and Volatility Modeling
- Clostridium difficile and Clostridium perfringens research
- Blockchain Technology Applications and Security
- Geophysics and Gravity Measurements
- Gene expression and cancer classification
Stony Brook University
2016-2025
State University of New York
2010-2025
Shanghai Academy of Spaceflight Technology
2024
Huzhou University
2024
Guang’anmen Hospital
2024
China Academy of Chinese Medical Sciences
2024
Changchun University of Chinese Medicine
2024
Beijing University of Chinese Medicine
2024
Guangdong Medical College
2019-2022
Applied Mathematics (United States)
2003-2022
Abnormal host-microbe interactions are implicated in the pathogenesis of inflammatory bowel diseases. Previous 16S rRNA sequence analysis intestinal tissues demonstrated that a subset Crohn's disease (CD) and ulcerative colitis (UC) samples exhibited altered intestinal-associated microbial compositions characterized by depletion Bacteroidetes Firmicutes (particularly Clostridium taxa). We hypothesize NOD2 ATG16L1 risk alleles may be associated with these alterations.To test this hypothesis,...
Background Subjective cognitive impairment (SCI) in older persons without manifest symptomatology is a common condition with largely unclear prognosis. We hypothesized that (1) examining outcome for sufficient period by using conversion to mild (MCI) or dementia would clarify SCI prognosis, and (2) the aforementioned procedures, prognosis of subjects differ significantly from demographically matched healthy subjects, free SCI, termed no (NCI) subjects. Methods A consecutive series aged ≥40...
Subjects with binge eating disorder (BED) regularly consume large amounts of food in short time periods. The neurobiology BED is poorly understood. Brain dopamine, which regulates motivation for intake, likely to be involved. We assessed the involvement brain dopamine consumption eaters. Positron emission tomography (PET) scans [(11)C]raclopride were done 10 obese and 8 subjects without BED. Changes extracellular striatum response stimulation food-deprived evaluated after placebo oral...
We tested the hypothesis that Crohn's disease (CD)-related genetic polymorphisms involved in host innate immunity are associated with shifts human ileum-associated microbial composition a cross-sectional analysis of ileal samples. Sanger sequencing bacterial 16S ribosomal RNA (rRNA) gene and 454 rRNA hypervariable regions (V1-V3 V3-V5), were conducted on macroscopically disease-unaffected biopsies collected from 52 CD, 58 ulcerative colitis 60 control patients without inflammatory bowel...
In order to assess potential associations between autism spectrum disorder (ASD) phenotype, functional GI disorders and fecal microbiota, we recruited simplex families, which had only a single ASD proband neurotypical (NT) siblings, through the Simons Simplex Community at Interactive Autism Network (SSC@IAN). Fecal samples metadata related diet were collected from probands NT siblings of (age 7-14). Functional gastrointestinal (FGID) assessed using parent-completed ROME III questionnaire for...
Abstract Methylphenidate (Ritalin) is an effective drug in the treatment of attention deficit hyperactivity disorder. However, doses required therapeutically vary significantly between subjects and it not understood what determines these differences. Since methylphenidate's therapeutic effects are part due to increases extracellular DA secondary blockade dopamine transporters (DAT), variability could reflect differences levels DAT blockade. Here we used PET assess if for a given dose...
The reinforcing effects of drugs abuse result from the complex interaction between pharmacological and conditioned responses. Here we evaluate how expectation affects response to stimulant drug methylphenidate in 25 cocaine abusers. (0.5 mg/kg, i.v.) on brain glucose metabolism (measured by [18F]deoxyglucose-positron emission tomography) its (self-reports effects) were evaluated four conditions: (1) expecting placebo receiving placebo; (2) methylphenidate; (3) (4) placebo. Methylphenidate...
Although impaired inhibitory control is linked to a broad spectrum of health problems, including obesity, the brain mechanism(s) underlying voluntary hunger are not well understood. We assessed circuits involved in inhibition during food stimulation 23 fasted men and women using PET 2-deoxy-2[(18)F]fluoro-D-glucose ((18)FDG). In men, but women, with significantly decreased activation amygdala, hippocampus, insula, orbitofrontal cortex, striatum, which regions emotional regulation,...
Abstract Objective Eating behavior in humans is influenced by variables other than just hunger‐satiety including cognitive restraint, emotional distress, and sensitivity to food stimuli. We investigate the role of dopamine (DA), a neurotransmitter involved with motivation, these variables. Methods used Dutch Behavior Questionnaire (DEBQ) measure Restraint, Emotionality, Externality 10 subjects. correlated DEBQ scores brain DA levels. Positron emission tomography { 11 C}raclopride uptake were...
We propose a comprehensive pattern recognition procedure that will achieve best discrimination between two or more sets of subjects with data in the same coordinate system. Applying to MS proteomic analysis serum from ovarian cancer patients and cancer-free individuals Food Drug Administration/National Cancer Institute Clinical Proteomics Database, we have achieved perfect (100% sensitivity, 100% specificity) cancer, including early-stage disease, normal controls for independent data. Our...
The neurobiological mechanisms underlying overeating in obesity are not understood. Here, we assessed the responses to an Implantable Gastric Stimulator (IGS), which induces stomach expansion via electrical stimulation of vagus nerve identify brain circuits responsible for its effects decreasing food intake. Brain metabolism was measured with positron emission tomography and 2-deoxy-2[ 18 F]fluoro- d -glucose seven obese subjects who had IGS implanted 1–2 years. evaluated twice during...
Objective Brain dopamine dysfunction in attention deficit/hyperactivity disorder (ADHD) could explain why stimulant medications, which increase signaling, are therapeutically beneficial. However while the acute increases induced by medications have been associated with symptom improvement ADHD chronic effects not investigated. Method We used positron emission tomography and [11C]cocaine (dopamine transporter radioligand) to measure availability brains of 18 never-medicated adult subjects...
Abstract Background High throughput parallel sequencing, RNA-Seq, has recently emerged as an appealing alternative to microarray in identifying differentially expressed genes (DEG) between biological groups. However, there still exists considerable discrepancy on gene expression measurements and DEG results the two platforms. The objective of this study was compare paired-end RNA-Seq data generated 5-azadeoxy-cytidine (5-Aza) treated HT-29 colon cancer cells with additional simulation study....
Although acute cardiac injury (ACI) is a known COVID-19 complication, whether ACI acquired during recovers unknown. This study investigated the incidence of persistent and identified clinical predictors recovery in hospitalized patients with 2.5 months post-discharge.
Climate change is a critical issue of our time, and its causes, pathways, forecasts remain topic broader discussion. In this paper, we present novel data driven pathway analysis framework to identify the key processes behind mean global temperature sea level rise, forecast magnitude their increase from 2100. Based on historical dynamic statistical modeling alone, have established causal pathways that connect increasing greenhouse gas emissions level, with intermediate links encompassing...
Regression analysis, especially the ordinary least squares method which assumes that errors are confined to dependent variable, has seen a fair share of its applications in aerosol science. The approach, however, could be problematic due fact atmospheric data often does not lend itself calling one variable independent and other dependent. Errors exist for both measurements. In this work, we examine two regression approaches available accommodate situation. They orthogonal geometric mean...
Associations between plants and microorganisms are very complex the subject of an increasing number studies. Here, we specifically address relationship poplar its endophytic bacteria. The role importance bacteria in growth development their host is still underestimated. However, since many endophytes have a beneficial effect on host, improved understanding interaction has potential to provide major breakthroughs that will improve productivity poplar. Endophytic can plant direct or indirect...