A5100376685- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Mast cells and histamine
- Gut microbiota and health
- Gene expression and cancer classification
- Estrogen and related hormone effects
- Clostridium difficile and Clostridium perfringens research
- Peptidase Inhibition and Analysis
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- Esophageal Cancer Research and Treatment
- Wnt/β-catenin signaling in development and cancer
- Single-cell and spatial transcriptomics
- Ubiquitin and proteasome pathways
- Inflammatory Bowel Disease
- Neonatal Respiratory Health Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
National Clinical Research
2022-2025
Molecular Oncology (United States)
2009-2025
Guizhou University
2022-2024
Fujian Agriculture and Forestry University
2024
Wenzhou Medical University
2023-2024
Chinese University of Hong Kong
2022-2024
Kunming Medical University
2024
Yan'an Hospital Affiliated To Kunming Medical University
2024
First Hospital of China Medical University
2024
Abnormal host-microbe interactions are implicated in the pathogenesis of inflammatory bowel diseases. Previous 16S rRNA sequence analysis intestinal tissues demonstrated that a subset Crohn's disease (CD) and ulcerative colitis (UC) samples exhibited altered intestinal-associated microbial compositions characterized by depletion Bacteroidetes Firmicutes (particularly Clostridium taxa). We hypothesize NOD2 ATG16L1 risk alleles may be associated with these alterations.To test this hypothesis,...
In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with checkpoint inhibitors is still not very clear. We utilize single-cell RNA- and ATAC-sequencing to examine immune cell dynamics in 22 patients advanced TNBC treated paclitaxel or its combination anti-PD-L1 atezolizumab. demonstrate that high levels baseline CXCL13+ T cells are linked proinflammatory features macrophages can predict effective responses therapy. responsive patients, lymphoid tissue inducer (LTi)...
Autism spectrum disorder (ASD) is a severe brain development that characterized by deficits in social communication and restricted, repetitive stereotyped behaviors. Accumulating evidence has suggested gut microbiota disorders play important roles gastrointestinal symptoms neurodevelopmental dysfunction ASD patients. Manipulation of the fecal transplantation (FMT) was recently shown to be promising therapy for treatment various diseases. Here, we performed clinical trial evaluate effect FMT...
Combining immune checkpoint blockade (ICB) with chemotherapy shows promise for treating triple-negative breast cancer (TNBC), though the mechanisms remain incompletely understood. Here, we integrate published and new single-cell RNA sequencing (scRNA-seq) data to investigate tumor microenvironment (TIME) in TNBC patients treated paclitaxel (PTX), nab-paclitaxel (Nab-PTX), their combinations anti-PD-L1 antibody atezolizumab (ATZ). Compared ATZ plus PTX, Nab-PTX rewires TCF7+ stem-like...
Abstract In prostate cancer, androgen receptor (AR) binding and androgen-responsive gene expression are defined by hormone-independent patterns of the pioneer factors FoxA1 GATA2. Insufficient evidence mechanisms which GATA2 contributes to this process precludes complete understanding a key determinant tissue-specific AR activity. Our observations suggest that facilitates three distinct modes action. By occupying novel sites within locus, positively regulates before after stimulation....
ABSTRACT This study investigated a metabolic network (MN) from Mycobacterium vanbaalenii PYR-1 for polycyclic aromatic hydrocarbons (PAHs) the perspective of structure, behavior, and evolution, in which multilayer omics data are integrated. Initially, we utilized high-throughput proteomic analysis to assess protein expression response M. seven different compounds. A total 3,431 proteins (57.38% genome-predicted proteins) were identified, included 160 that seemed be involved degradation...
Abstract Background Breast cancer (BC) is the most frequently diagnosed and leading cause of cancer-associated deaths in women. Recent studies have indicated that microRNA (miRNA) regulation genomic instability (GI) associated with disease risk clinical outcome. Herein, we aimed to identify GI-derived miRNA signature extracellular vesicles (EVs) as a minimally invasive biomarker for early diagnosis prognostic stratification. Experimental design Integrative analysis expression somatic...
The utility of cell-free nucleic acids in monitoring cancer has been recognized by both scientists and clinicians. In addition to human transcripts, a fraction plasma were proven be derived from microbes reported have relevance cancer. To obtain better understanding RNAs (cfRNAs) patients, we profiled cfRNAs ~300 samples 5 types (colorectal cancer, stomach liver lung esophageal cancer) healthy donors (HDs) with RNA-seq. Microbe-derived consistently detected different computational methods...
Detecting early-stage esophageal squamous cell carcinoma (ESCC) and precancerous lesions is critical for improving survival. Here, we conduct whole-genome bisulfite sequencing (WGBS) on 460 cfDNA samples from patients with non-metastatic ESCC or matched healthy controls. We develop an expanded multimodal analysis (EMMA) framework to simultaneously identify methylation, copy number variants (CNVs), fragmentation markers in WGBS data. methylation are the earliest most sensitive, detectable 70%...
Wnt signaling is mediated through 1) the beta-catenin dependent canonical pathway and, 2) independent pathways. Multiple receptors, including Fzds, Lrps, Ror2 and Ryk, are involved in signaling. a single-span transmembrane receptor-tyrosine kinase (RTK). The functions of mediating non-canonical have been well established. role not fully understood. Here we report that also positively modulates Wnt3a-activated lung carcinoma, H441 cell line. This activity on cooperative interactions with Fzd2...
Sentinel lymph node (LN) biopsy is currently the standard procedure for clinical LN‐negative breast cancer (BC) patients but it prone to false‐negative results and complications. Thus, an accurate noninvasive approach LN staging urgently needed in practice. Here, circulating exosomal microRNA (miRNA) expression profiles peripheral blood from BC age‐matched healthy women were obtained analyzed. We identified miRNA, miR‐363‐5p , that was significantly downregulated exosomes plasma of with...
CDK4/6 inhibitors combined with endocrine therapy has become the preferred treatment approach for patients estrogen receptor-positive metastatic breast cancer. However, predictive biomarkers and mechanisms of innate resistance to remain largely unknown. We sought elucidate molecular hallmarks therapeutically actionable features inhibitors.
Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically relevant biomarkers for early detection. Here, we comprehensively characterized the transcriptional landscape of long non-coding RNAs (lncRNAs) in paired tumor and normal tissue specimens from 93 ESCC patients, identified six key malignancy-specific lncRNAs that were integrated into Multi-LncRNA Malignancy Risk Probability model (MLMRPscore). The MLMRPscore performed robustly distinguishing controls multiple...
Abstract Exosomes play a crucial role in intercellular communication and can be used as biomarkers for diagnostic therapeutic clinical applications. However, systematic studies cancer-associated exosomal nucleic acids remain big challenge. Here, we developed ExMdb, comprehensive database of acid disease-gene associations curated from published literature high-throughput datasets. We performed curation exosome properties including 4,586 experimentally supported gene-disease associations,...
Background and Objective: Anxiety/depression tuberculosis are global public health problems. The incidence of psychiatric morbidities is high among patients. However, little known about the prevalence anxiety depression Chinese pulmonary (PTB) patients, especially those with tracheobronchial (TBTB). goal present study was to explore associated factors depressive symptoms PTB patients without TBTB. Methods: A cross-sectional survey from three hospitals in Liaoning, China, conducted using a...
S100A7 is an EF-hand calcium-binding protein that has been suggested to be implicated in cell proliferation, migration, invasion and tumor metastasis. However, its role cervical cancer not yet fully clarified. The present study used immunohistochemistry analysis of clinical specimens show expression was significantly upregulated tissues compared with normal high grade intraepithelial neoplasm (CIN) higher than cancer. Statistical showed associated (P <0.01) lymph node metastasis <0.05)....
Rationale: Chemokines contribute to cancer metastasis and have long been regarded as attractive therapeutic targets for cancer. However, controversy exists about whether neutralizing chemokines by antibodies promotes or inhibits tumor metastasis, suggesting that the approach directly target needs be scrutinized. Methods: Transwell assay, mouse experiments survival analysis were performed determine functional role of S100A14 in breast RNA-Seq, secreted proteomics, ChIP, Western blot, ELISA,...
Ubiquitination and deubiquitination are important post-translational regulatory mechanisms responsible for fine tuning the antiviral signaling. In this study, we identified a deubiquitinase, ubiquitin-specific peptidase 7/herpes virus associated protease (USP7/HAUSP) as an negative modulator of virus-induced Overexpression USP7 suppressed Sendai polyinosinic-polycytidylic acid poly(deoxyadenylic-deoxythymidylic)-induced ISRE IFN-β activation, enhanced replication. Knockdown or knockout...