A5051968581- Advanced Breast Cancer Therapies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Estrogen and related hormone effects
- Cancer Treatment and Pharmacology
- Electrowetting and Microfluidic Technologies
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Lysosomal Storage Disorders Research
- Cancer, Hypoxia, and Metabolism
- Muscle Physiology and Disorders
- Trypanosoma species research and implications
- Flavonoids in Medical Research
- RNA modifications and cancer
- Enzyme Production and Characterization
- Geoscience and Mining Technology
- Mesenchymal stem cell research
- Microfluidic and Capillary Electrophoresis Applications
- Cellular transport and secretion
- Geochemistry and Geologic Mapping
- Acute Ischemic Stroke Management
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Viral Infectious Diseases and Gene Expression in Insects
- Enzyme Catalysis and Immobilization
- Food composition and properties
Microbiology Institute of Shaanxi
2019-2025
Institute of Microbiology
2019-2025
Chinese Academy of Sciences
2019-2025
University of Chinese Academy of Sciences
2019-2025
Huizhou Central People's Hospital
2005-2025
Jiangnan University
2022-2024
State Key Laboratory of Food Science and Technology
2024
Guangdong Medical College
2024
Fujian Agriculture and Forestry University
2024
Qinghai Normal University
2021
Abstract Digital PCR (dPCR) holds immense potential for precisely detecting nucleic acid markers essential personalized medicine. However, its broader application is hindered by high consumable costs, complex procedures, and restricted multiplexing capabilities. To address these challenges, an all‐in‐one dPCR system introduced that eliminates the need microfabricated chips, offering fully automated operations enhanced Using this innovative oscillation‐induced droplet generation technique,...
Digital PCR is a powerful method for absolute nucleic acid quantification with unprecedented accuracy and precision. To promote the wider use application of digital PCR, several major challenges still exist, including reduction cost, integration instrumental platform, simplification operations. This paper describes reusable microfluidic device that generates nanoliter droplet arrays based on step emulsification on-chip multiplex eight samples simultaneously. The contains two glass plates can...
CDK4/6 inhibitors combined with endocrine therapy has become the preferred treatment approach for patients estrogen receptor-positive metastatic breast cancer. However, predictive biomarkers and mechanisms of innate resistance to remain largely unknown. We sought elucidate molecular hallmarks therapeutically actionable features inhibitors.
An improved microfluidic streak plate technique relying on droplet microfluidics can advance the exploration of deep-sea rare microbes.
This paper describes OsciDrop, a versatile chip-free droplet generator used to produce size-tunable droplets on demand. Droplet generation is fundamental miniaturized analysis. We designed OsciDrop segment the fluid flowing out of orifice disposable pipette tip into by oscillating its distal end underneath an immiscible continuous phase. described theoretical model and investigated effect flow rate, amplitude, frequency, waveform generation. Our study revealed previously underexplored Weber...
Abstract Leaves have evolved shape diversity, ranging from simple leaves with a smooth margin to complicated shapes toothed/serrated, lobed, and dissected leaflets. In the model plant Arabidopsis thaliana producing serrated margin, boundary regulatory factor genes CUP SHAPED COTYLEDON 2 (CUC2) CUC3 play important roles in promoting leaf initiation maintenance of serration. Stem cell-related WUSCHEL-RELATED HOMEOBOX1 (WOX1) PRESSED FLOWER (PRS)/WOX3 are also essential for morphogenesis, but...
Anti-sulfatide antibodies are autoantibodies that associated with various neurological disorders. They have been identified in several conditions including Guillain-Barré syndrome, multiple sclerosis, and chronic inflammatory demyelinating polyneuropathy. Subacute combined degeneration of the spinal cord is mainly caused by vitamin B12 deficiency. Chronic atrophic gastritis a complex condition characterized atrophy inflammation gastric mucosa. To date, there no reported cases patients...
Abstract Neonatal pneumonia is a leading cause of infant mortality worldwide; however, lack microbial profiling, especially low-abundance species, makes accurate diagnosis challenging. Traditional methods can fail to capture the complexity neonatal respiratory microbiota, thereby obscuring its role in disease progression. We describe novel approach that combines high-throughput sequencing with droplet-based microfluidic cultivation investigate microbiome shifts neonates pneumonia. Using 16S...
D-Allulose, a low-calorie rare sugar with various physiological functions, is mainly produced through the isomerization of D-fructose by ketose 3-epimerases (KEases), which exhibit substrate specificities. A novel KEase from Clostridia bacterium (CDAE) was identified to be D-allulose 3-epimerase and further characterized as thermostable metal-dependent. In order explore its structure-function relationship, crystal structure CDAE determined using X-ray diffraction at 2.10 Å resolution,...
Healthcare workers are an indispensable part of society, and a healthy mind body important to them, but today's exacerbation psychological problems in healthcare, has attracted the attention society. This study spans two particular phases: COVID-19 pandemic phase full liberalization epidemic control. To explore trends mental health status healthcare workers, particularly anxiety, depression sleep quality, analyze influencing factors inform development interventions through data collection...
Krabbe disease (also known as globoid cell leukodystrophy) cause by a deficiency of the enzyme β-galactocerebrosidase (galactosylceramidase, GALC). The GALC leads to accumulation galactosylceramide and psychosine, latter substrate having potential role in triggering demyelination. Typically, has an infantile onset, with rapid deterioration first few months, leading death before age 2 years. late onset forms (late-infantile, juvenile, adult forms) are rare variable clinical outcomes,...
Pancreatic encephalopathy (PE) is a common fatal complication of acute pancreatitis (AP). Proinflammatory cytokines such as tumor necrosis factor (TNF)‑α and interleukin (IL)‑6 are generated during AP, act synergistically to promote PE multisystem failure. Caerulein‑induced AP provides convenient model explore the role proinflammatory in PE. The aim present study was examine effect TNF‑α inhibitor etanercept models elucidate regulatory mechanisms. To vitro, rat hippocampal H19‑7/IGF‑IR...