A5020790049- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Radiomics and Machine Learning in Medical Imaging
- Genetics, Bioinformatics, and Biomedical Research
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Lung Cancer Treatments and Mutations
- Magnetic confinement fusion research
- Acute Ischemic Stroke Management
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Superconducting Materials and Applications
- Particle accelerators and beam dynamics
- Immunotherapy and Immune Responses
- Dialysis and Renal Disease Management
- Neuroscience and Music Perception
- Chemotherapy-related skin toxicity
- Traumatic Brain Injury and Neurovascular Disturbances
- Music Therapy and Health
- Circular RNAs in diseases
- Radiation Dose and Imaging
Second Affiliated Hospital of Zhejiang University
2023-2025
Siemens (China)
2016-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2022
Peking Union Medical College Hospital
2020-2022
Tencent Healthcare (China)
2020-2022
Tencent (China)
2021
Institute of Dermatology
2020
In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with checkpoint inhibitors is still not very clear. We utilize single-cell RNA- and ATAC-sequencing to examine immune cell dynamics in 22 patients advanced TNBC treated paclitaxel or its combination anti-PD-L1 atezolizumab. demonstrate that high levels baseline CXCL13+ T cells are linked proinflammatory features macrophages can predict effective responses therapy. responsive patients, lymphoid tissue inducer (LTi)...
Abstract Background Colposcopy diagnosis and directed biopsy are the key components in cervical cancer screening programs. However, their performance is limited by requirement for experienced colposcopists. This study aimed to develop validate a Colposcopic Artificial Intelligence Auxiliary Diagnostic System (CAIADS) grading colposcopic impressions guiding biopsies. Methods Anonymized digital records of 19,435 patients were obtained from six hospitals across China. These included images,...
Sentinel lymph node (LN) biopsy is currently the standard procedure for clinical LN‐negative breast cancer (BC) patients but it prone to false‐negative results and complications. Thus, an accurate noninvasive approach LN staging urgently needed in practice. Here, circulating exosomal microRNA (miRNA) expression profiles peripheral blood from BC age‐matched healthy women were obtained analyzed. We identified miRNA, miR‐363‐5p , that was significantly downregulated exosomes plasma of with...
Lung cancer is the top cause for deaths by cancers whose 5-year survival rate less than 20%. To improve of patients with lung cancers, early detection and diagnosis significant. Furthermore, pulmonary nodules essential in stage. The National Screening Trial (NLST) showed annual screening low-dose computed tomography (LDCT) could help to reduce caused high-risk subjects 20% comparing chest radiography. In past decade, there has been lots works on computer-aided (CADe) (CADx) (CT) scans,...
How pain emerges from cortical activities remains an unresolved question in neuroscience. A first step toward addressing this consists identifying brain that occur preferentially response to painful stimuli comparison non-painful stimuli. key confound has affected important many previous studies is the intensity of generating and sensations. Here, we compared activity during iso-intense tactile sensations sampled by functional MRI 51 healthy participants. Specifically, perceived was recorded...
Abstract The fragmentomics-based cellfree DNA (cfDNA) assays have recently illustrated prominent abilities to identify various cancers from non-conditional healthy controls, while their accuracy for identifying early-stage benign lesions with inconclusive imaging results remains uncertain. Especially breast cancer, current imaging-based screening methods suffer high false positive rates women nodules, leading unnecessary biopsies, which add discomfort and healthcare burden. Here, we...
Abstract Advanced stellarators are typically optimized in two stages. The plasma equilibrium is first, followed by the design of coils/permanent magnets. However, magnets second stage may become too complex to achieve desired equilibrium. To address this problem, a quasi-single-stage optimization method has been proposed. In paper, we introduce for designing permanent magnet (PM) stellarators. new approach combines straightforward PM metrics penalize maximum required thickness and mismatch...
Cerebral venous oxygen saturation (SvO2) is an important biomarker of brain function. In this study, we aimed to explore the relative changes regional cerebral SvO2 among axonal injury (AI) patients, non-AI patients and healthy controls (HCs) using quantitative susceptibility mapping (QSM). 48 32 HCs were enrolled. The divided into two groups depending on imaging based evidence AI. QSM was used measure major veins. Nonparametric testing performed for differences patient group, AI group...
Sintilimab is a fully human monoclonal antibody targeting PD-1, which has been considered well tolerated among patients and widely applied in malignancies.We present case report of patient with gallbladder carcinoma treated sintilimab who developed toxic epidermal necrolysis (TEN). A 72-year-old female presented fever maculopapular rash after receiving one dose for metastatic carcinoma. Widespread rashes progressive skin detachment occurred within week. Early biopsy the showed apoptotic...
Background The cerebral iron overload in hemodialysis patients has been reported a previous study, which the evaluation of changes content could be affected by cross‐sectional analysis. Purpose To investigate longitudinal deposition using quantitative susceptibility mapping (QSM) and correlate these findings with neurocognitive function clinical factors. Study Type Prospective; longitudinal. Population In all, 34 30 healthy controls (HCs); mean follow‐up interval was 22 ± 7 months. Field...
Abstract Background Identifying breast cancer patients with DNA repair pathway-related germline pathogenic variants (GPVs) is important for effectively employing systemic treatment strategies and risk-reducing interventions. However, current criteria risk prediction models prioritizing genetic testing among do not meet the demands of clinical practice due to insufficient accuracy. Methods The study population comprised 3041 enrolled from seven hospitals between October 2017 11 August 2019,...
Objectives In this preregistered study, we investigated the beneficial effects of music-based casual video game training on depression, anxiety and stress symptoms in a cohort young individuals with subthreshold depression underlying mechanisms. Methods The study included 56 (18–26 years age) or mild based Beck Depression Inventory-II (BDI-II) scores between 14 19. They were randomly assigned into experimental group ( n = 28) control 28). underwent for 4 weeks. During same time, participants...
The use of shorter TR and finer atlases in rs-fMRI can provide greater detail on brain function anatomy. However, there is limited understanding the effect this combination network properties.A study was conducted with 20 healthy young volunteers who underwent scans both (0.5s) long (2s) TR. Two different degrees granularity (90 vs 200 regions) were used to extract signals. Several metrics, including small-worldness, Cp, Lp, Eloc, Eg, calculated. Two-factor ANOVA two-sample t-tests for...
Background: Lymph node metastasis (LNM) is an independent risk factor for prognosis in patients with early breast cancer (EBC). Here we explored whether peripheral lymphocyte subtypes could be used as surrogate markers LNM EBC. Materials & methods: The subpopulations blood were measured 152 EBC and 43 benign tumors. Results: cytotoxic T cell count was significantly lower than tumors (244.17 ± 105.83 vs 289.97 121.72; p = 0.02), especially (218.36 86.21; 0.04). Conclusion: A decreased level...
Advanced stellarators are typically optimized in two stages. The plasma equilibrium is first, followed by the design of coils/permanent magnets. However, magnets second stage may become too complex to achieve desired equilibrium. To address this problem, single-stage optimization methods have been proposed. In paper, we introduce a novel method for designing permanent magnet (PM) stellarators. This approach combines straightforward PM metrics penalize maximum required thickness and mismatch...
Motivation: While 3D acquisition has the advantages of achieving high resolution and signal-to-noise ratio been established for most sequences, diffusion imaging, predominantly adhered to 2D or partial such as multi-slab over 50 years. Goal(s): We aim bring imaging next era by implementing a genuine sequence. Approach: The sequence was implemented using gradient moment nulling EPI basic reconstruction methods. Results: Whole brain achieved at isotropic sub-millimeter practical scan time....
Till March 31st, 2021, the coronavirus disease 2019 (COVID-19) had reportedly infected more than 127 million people and caused over 2.5 deaths worldwide. Timely diagnosis of COVID-19 is crucial for management individual patients as well containment highly contagious disease. Having realized clinical value non-contrast chest computed tomography (CT) COVID-19, deep learning (DL) based automated methods have been proposed to aid radiologists in reading huge quantities CT exams a result...
Abstract Purpose We aim to implement a 3D DWI sequence and show its usage on patients with new ischemic lesions. Materials Methods The proposed was implemented by integrating second-order gradient moment nulling (M2) cardiac motion synchronization (Sync). All data were acquired 3T MAGNETOM Prisma scanner (Siemens Healthcare, Erlangen, Germany) using 64 channel head neck coil. 21 healthy volunteers underwent scans at 0.9 mm isotropic resolution four compensation methods for comparison: no...