A5010123075- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- T-cell and Retrovirus Studies
- COVID-19 and healthcare impacts
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Vector-Borne Animal Diseases
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Hematopoietic Stem Cell Transplantation
- Cancer-related gene regulation
- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
Albert Einstein College of Medicine
2016-2025
Montefiore Medical Center
2016-2025
Montefiore Einstein Comprehensive Cancer Center
2022-2024
Sidney Kimmel Comprehensive Cancer Center
2023
Johns Hopkins University
2023
The University of Texas MD Anderson Cancer Center
2023
Cancer Institute (WIA)
2022
The Bronx Defenders
2021
Yeshiva University
2019
Cornell University
2019
Abstract Patients with cancer are presumed to be at increased risk from COVID-19 infection–related fatality due underlying malignancy, treatment-related immunosuppression, or comorbidities. A total of 218 COVID-19–positive patients March 18, 2020, April 8, a malignant diagnosis were identified. 61 (28%) died case rate (CFR) 37% (20/54) for hematologic malignancies and 25% (41/164) solid malignancies. Six 11 (55%) lung disease. Increased mortality was significantly associated older age,...
<h3>Context</h3>Attention-deficit/hyperactivity disorder (ADHD)—characterized by symptoms of inattention and hyperactivity-impulsivity—is the most prevalent childhood psychiatric that frequently persists into adulthood, there is increasing evidence reward-motivation deficits in this disorder.<h3>Objective</h3>To evaluate biological bases might underlie a reward/motivation deficit imaging key components brain dopamine reward pathway (mesoaccumbens).<h3>Design, Setting, Participants</h3>We...
The value of rewards (natural and drugs) is associated with dopamine increases in the nucleus accumbens varies as a function context. prefrontal cortex has been implicated context dependency fixated high that drugs have addiction, although mechanisms are not properly understood. Here we test hypothesis regulates by modulating this regulation disrupted addicted subjects. We used positron emission tomography to evaluate activity (measuring brain glucose metabolism [18F]fluorodeoxyglucose)...
Obesity has been associated with a higher risk for impaired cognitive function, which most likely reflects medical complications (i.e., cerebrovascular pathology). However, there is also evidence that in healthy individuals excess weight may adversely affect cognition (executive attention, and memory). Here, we measured regional brain glucose metabolism (using positron emission tomography (PET) 2-deoxy-2[(18)F]fluoro-D-glucose (FDG)) to assess the relationship between BMI (marker of...
Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent psychiatric of childhood. There considerable evidence that brain dopamine involved in ADHD, but it unclear whether activity enhanced or depressed.To test hypotheses striatal depressed ADHD and this contributes to symptoms inattention.Clinical (ADHD adult) comparison (healthy control) subjects were scanned with positron emission tomography raclopride labeled carbon 11 (D2/D3 receptor radioligand sensitive competition...
Understanding how brain activation mediates behaviors is a central goal of systems neuroscience. Here, we apply an automated method for mapping in the mouse order to probe sex-specific social are represented male brain. Our uses immediate-early-gene c-fos, marker neuronal activation, visualized by serial two-photon tomography: c-fos-GFP+ neurons computationally detected, their distribution registered reference and atlas, numbers analyzed statistical tests. results reveal distinct shared...
Although impaired inhibitory control is linked to a broad spectrum of health problems, including obesity, the brain mechanism(s) underlying voluntary hunger are not well understood. We assessed circuits involved in inhibition during food stimulation 23 fasted men and women using PET 2-deoxy-2[(18)F]fluoro-D-glucose ((18)FDG). In men, but women, with significantly decreased activation amygdala, hippocampus, insula, orbitofrontal cortex, striatum, which regions emotional regulation,...
Sleep deprivation can markedly impair human performance contributing to accidents and poor productivity. The mechanisms underlying this impairment are not well understood, but brain dopamine systems have been implicated. Here, we test whether one night of sleep changes activity. We studied 15 healthy subjects using positron emission tomography [ 11 C]raclopride (dopamine D 2 /D 3 receptor radioligand) C]cocaine transporter radioligand). Subjects were tested twice: after rested deprivation....
Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating formation of cancer fibroblasts (CAFs) are not well elucidated. An epigenomic analysis patient-derived and de-novo generated CAFs demonstrated widespread loss cytosine methylation that was overexpression various inflammatory transcripts including CXCR4. Co-culture neoplastic cells led to increased invasiveness abrogated by inhibition Metabolite tracing revealed lactate...
Major efforts are underway to identify agents that can potentiate effects of immune checkpoint inhibition. Here, we show ascorbic acid (AA) treatment caused genomewide demethylation and enhanced expression endogenous retroviral elements in lymphoma cells. AA also increased 5-hydroxymethylcytosine (5hmC) levels CD8+ T cells their cytotoxic activity a coculture system. High-dose synergized with anti-PD1 therapy syngeneic mouse model, resulting marked inhibition tumor growth compared either...
Abstract The novel coronavirus SARS-CoV2 has been observed to cause a higher incidence and greater severity of disease in males, as seen multiple cohorts across the globe. reasons for gender disparity is unclear can be due host factors. To determine whether males have delayed viral clearance after infection, we evaluated time symptomatic patients tested by serial oropharyngeal/nasopharyngeal swabs followed RT-PCR at reference lab Mumbai, India. A total 68 subjects with median age 37 years...
Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that not eliminated by conventional therapies. Transcriptomic analysis of progenitor populations in MDS AML demonstrated overexpression STAT3 was validated an independent cohort. predictive a shorter survival worse clinical features large High expression signature CD34+ similar to known preleukemic gene signatures. Functionally, inhibition clinical, antisense oligonucleotide,...
Although clear cell renal carcinoma (ccRCC) has been shown to result in widespread aberrant cytosine methylation and loss of 5-hydroxymethylcytosine (5hmC), the prognostic impact therapeutic targeting this epigenetic aberrancy not fully explored. Analysis 576 primary ccRCC samples demonstrated that 5hmC was strongly associated with aggressive clinicopathologic features an independent adverse factor. Loss also predicted reduced progression-free survival after resection nonmetastatic disease....
Mutations in the SF3B1 splicing factor are commonly seen myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), yet specific oncogenic pathways activated by mis-splicing have not been fully elucidated. Inflammatory immune shown to play roles pathogenesis of MDS, though exact mechanisms their activation mutant cases well understood.RNA-seq data from samples was analyzed functional interleukin-1 receptor-associated kinase 4 (IRAK4) isoforms were determined. Efficacy IRAK4 inhibition...
Abstract Black people have a higher incidence of colorectal cancer and worse survival rates when compared with white people. Comprehensive genomic profiling was performed in 46,140 adenocarcinoma cases. Ancestry-informative markers identified 5,301 patients African descent (AFR) 33,770 European (EUR). AFR were younger, had fewer microsatellite instability–high (MSI-H) tumors, significantly more frequent alterations KRAS, APC, PIK3CA. increased frequency KRAS mutations, specifically KRASG12D...