A5005481584- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Neuroscience, Education and Cognitive Function
- Axon Guidance and Neuronal Signaling
- Retinal Development and Disorders
- Advanced Neuroimaging Techniques and Applications
- Multisensory perception and integration
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
- EEG and Brain-Computer Interfaces
- Neurobiology and Insect Physiology Research
- Receptor Mechanisms and Signaling
- Cell Image Analysis Techniques
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Neural Networks and Applications
- Tactile and Sensory Interactions
- Visual and Cognitive Learning Processes
- Advanced Fluorescence Microscopy Techniques
Boston University
2016-2025
University School
2022-2023
RIKEN Center for Brain Science
2004-2020
Cold Spring Harbor Laboratory
2014-2016
Massachusetts Institute of Technology
2010-2012
RIKEN
2002-2010
National Institute for Physiological Sciences
2010
Saitama University
2006-2009
Research Organization of Information and Systems
2007
Keio University
2002
Abstract Intracortical injections of horseradish peroxidase (HRP) reveal a system periodically organized intrinsic connections in primate striate cortex. In layers 2 and 3 these form reticular or latticelike pattern, extending for about 1.5–2.0 mm around an injection. This connectional lattice is composed HRP‐labeled walls (350–450 μm apart Saimiri 500–600 macaque) surrounding unlabeled central lacunae. Within the there are regularly arranged punctate loci particularly dense HRP label,...
Intrinsic connections within the tree shrew ( Tupaia glis ) visual cortex (area 17) are organized in periodic stripelike patterns layers I, II, and III. This anatomical network resembles regularly stripes of 2-deoxyglucose accumulation seen after stimulation alert animals with uniformly oriented lines. Such imply that widespread lateral interactions superimposed on retinotopic organization area 17 suggest alternative interpretations cortical columns.
Understanding how brain activation mediates behaviors is a central goal of systems neuroscience. Here, we apply an automated method for mapping in the mouse order to probe sex-specific social are represented male brain. Our uses immediate-early-gene c-fos, marker neuronal activation, visualized by serial two-photon tomography: c-fos-GFP+ neurons computationally detected, their distribution registered reference and atlas, numbers analyzed statistical tests. results reveal distinct shared...
Abstract In the present study, anterograde tracer Phaseolus vulgaris ‐leucoagglutinin (PHA‐L) was injected into area V2 in order to demonstrate precise morphology of individual axons from V1. On basis 28 complete axon reconstructions, several characteristic features have been identified. (1) Individual arborize multiple layers: 1, 2, 5, and (inconstantly) 3. A single may numerous terminal clusters layers 1 but at most one layer (2) Axons typically ascend turn asymmetrically direction, travel...
Although there have been reports of sparse projections from temporal areas TE, TF, and even TH to area V1, it is generally believed that cortical afferents V1 originate exclusively prestriate areas. Injections anterograde tracers in anterior occipital areas, however, consistently produce labeled terminals V1. In order confirm these results display the full range foci projecting we injected two monkeys with retrograde tracer fast blue. Feedback connections were found, as expected, several...
Abstract The intrinsic connectivity of striate cortex was investigated by injecting horseradish peroxidase (HRP) into this area in tree shrews. Such HRP injections demonstrated periodically organized, stripelike connections within 17. These stripes occur layers I–IIIA and consist a small number retrogradely filled neurons, some clearly pyramidal, together with HRP‐labeled axon terminals. HRP‐filled trunks run between labeled stripes, interconnecting adjacent distant regions the stripe...
Abstract In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration modelling at multiple scales—from molecules to the whole brain. Major are emerging intersection of neuroscience with technology computing. This science combines high-quality research, across scales, culture multidisciplinary large-scale collaboration, translation into applications. As pioneered in Europe’s Human Brain Project...
Abstract Extrastriate areas TEO and V4 have been associated with form color vision. Area has also suggested to participate in processes concerned attention, stimulus salience, perceptual learning. In a continuing effort elucidate the connectional interactions microcircuitry of these areas, we describe this report pattern feedback connections from V4. Connections were demonstrated by injections high-resolution anterograde tracers PHA-L or biocytin further analyzed reconstruction 25 individual...
We examined the expression patterns of 4 layer-specific genes in monkey and mouse cortices by fluorescence double situ hybridization. Based on their coexpression profiles, we were able to distinguish several subpopulations deep layer neurons. One group was characterized ER81 lack Nurr1 mRNAs mainly localized 5. In monkeys, this neuronal further subdivided 5-HT2C receptor mRNA expression. The 5-HT2C+/ER81+ neurons located 5B most cortical areas, but they intruded 6 primary visual area (V1)....
A subgroup of GABAergic neurons has been reported to project over long distances in several species. Here we demonstrate that long-distance cortically projecting nonpyramidal occur monkeys both white and gray matter. Nonpyramidal were first identified morphologically. Visualization Golgi-like details was achieved by retrograde infection from injections an adenovirus vector, producing enhanced green fluorescent protein (EGFP) under control a neuron-specific promoter. Injections areas V1, V4,...
The COUP-TFII nuclear receptor, also known as NR2F2, is expressed in the developing ventral telencephalon and modulates tangential migration of a set subpallial neuronal progenitors during forebrain development. Little information available about its expression patterns adult brain. We have identified cell populations expressing contribution some them to network activity vivo . Expression by hippocampal pyramidal dentate granule cells, well neurons neocortex, formed gradient increasing from...
Abstract The retrosplenial cortex (RS) in rats has been implicated a wide range of behaviors, including spatial navigation and memory. Relevant to this, the RS is closely interconnected with hippocampus by multiple direct indirect routes. Here, injecting retrograde tracer cholera toxin subunit B conjugated Alexa488 (CTB‐Alexa488) granular (GRS), we demonstrate moderately dense non‐pyramidal projection from CA1. Neurons are several layers, but mainly (about 65%) at border stratum radiatum...
The spontaneously hypertensive rat (SHR) is the most widely studied animal model of hypertension. Scores SHR quantitative loci (QTLs) have been mapped for hypertension and other phenotypes. We sequenced SHR/OlaIpcv genome at 10.7-fold coverage by paired-end sequencing on Illumina platform. identified 3.6 million high-quality single nucleotide polymorphisms (SNPs) between Brown Norway (BN) reference genome, with a high rate validation (sensitivity 96.3%–98.0% specificity 99%–100%). also...
Large sectors of polymodal cortex project to the hippocampal formation via convergent input entorhinal cortex. The present study reports an additional access route, whereby several cortical areas directly CA1. These are parietal 7a and 7b, area TF medial occipitotemporal sulcus (OTS), a restricted in lateral bank OTS that may be part ventromedial TE. particular implicated visuospatial processes; their projection convergence within CA1 significant for elaboration 'view fields', postulated...
Corticopulvinar axons were anterogradely labeled by Phaseolus vulgaris-leucoagglutinin injections in the occipitotemporal cortex of macaque to determine quantitative parameters divergence and convergence, arbor size shape, distribution terminal specializations. Forty individual analyzed serial section reconstruction divided into two major groups. The majority have numerous (typically 500-1,000) small, spinous endings (boutons terminaux). These fields that are beam-like or elongated (E,...
The entorhinal and perirhinal cortices have long been accorded a special role in the communications between neocortical areas hippocampal formation. Less attention has paid to presubiculum, which, however, is also component of parahippocampal gyrus, receives dense inputs from several cortical areas, itself major source connections cortex (EC). In part closer investigation corticohippocampal systems, authors applied single-axon analysis inferior parietal lobule (IPL) presubiculum. One result...
Area V5 (middle temporal) in the superior temporal sulcus of macaque receives a direct projection from primary visual cortex (V1). By injecting anterograde tracers (biotinylated dextran and Phaseolus vulgaris lectin) into V1, we have examined synaptic boutons that they form electron microscope. Nearly 80% target cells were spiny (excitatory). The formed asymmetric (Gray's type 1) synapses with spines (54%), dendrites (33%), somata (13%). All somatic targets some (26%) dendritic shafts showed...