A5075655790- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Olfactory and Sensory Function Studies
- Conducting polymers and applications
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
Forschungszentrum Jülich
2020-2024
Royal Netherlands Academy of Arts and Sciences
2024
Netherlands Institute for Neuroscience
2012-2024
Neurons in the primary visual cortex (V1) receive feedforward input from thalamus, which shapes receptive-field properties. They additionally recurrent inputs via horizontal connections within V1 and feedback higher areas that are thought to be important for conscious perception. Here, we investigated what roles different glutamate receptors play conveying macaque V1. As a measure of processing, used figure-ground modulation (FGM), increased activity neurons representing figures compared...
Abstract In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration modelling at multiple scales—from molecules to the whole brain. Major are emerging intersection of neuroscience with technology computing. This science combines high-quality research, across scales, culture multidisciplinary large-scale collaboration, translation into applications. As pioneered in Europe’s Human Brain Project...
Fragments of mature tRNAs have long been considered as mere degradation products without physiological function. However, recent reports show that tRNA-derived small RNAs (tsRNAs) play prominent roles in diverse cellular processes across a wide spectrum species. Contrasting the situation other RNA pathways mechanisms behind these effects appear more diverse, complex, and are generally less well understood. In addition, surprisingly little is known about expression profiles tsRNAs different...
Abstract Objective . Electrical stimulation of visual cortex via a neuroprosthesis induces the perception dots light (‘phosphenes’), potentially allowing recognition simple shapes even after decades blindness. However, restoration functional vision requires large numbers electrodes, and chronic, clinical implantation intracortical electrodes in has only been achieved using devices up to 96 channels. We evaluated efficacy stability 1024-channel system non-human primates (NHPs) over more than...
Brain interfaces that can stimulate neurons, cause minimal damage, and work for a long time will be central future neuroprosthetics. Here, the long-term performance of highly flexible, thin polyimide shanks with several small (<15 µm) electrodes during electrical microstimulation visual cortex, is reported. The exhibit remarkable stability when billions pulses are applied in vitro. When devices implanted primary cortex (area V1) mice animals trained to detect microstimulation, it found...
Abstract The mouse is a useful and popular model for studying of visual cortical function. To facilitate the translation results from mice to primates, it important establish extent organization equivalence between species identify possible differences. We focused on different types interneurons as defined by calcium-binding protein (CBP) expression in layers primary cortex (V1) rhesus macaque. CBPs parvalbumin (PV), calbindin (CB), calretinin (CR) provide standard, largely nonoverlapping,...
Glutamate receptors mediate excitatory neurotransmission. A very prevalent type of glutamate receptor in the neocortex is AMPA (AMPAR). AMPARs fast synaptic transmission and their functionality depends on subunit composition. In primary visual cortex (area V1), density composition differ among cortical layers cell types. The expressed by different types inhibitory interneurons, which are crucial for network function, have not yet been characterized systematically. We investigated...
Abstract Fragments of mature tRNAs have long been considered as mere degradation products without physiological function. However, recent reports show that tRNA fragments (tRFs) play prominent roles in diverse cellular processes across a wide spectrum species. Contrasting the situation other small RNA pathways mechanisms behind these effects appear more diverse, complex and are generally less well understood. In addition, surprisingly little is known about expression profiles tRFs different...