A5017337262- Acute Myeloid Leukemia Research
- Eicosanoids and Hypertension Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- Folate and B Vitamins Research
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Drug Transport and Resistance Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Immune Response and Inflammation
- Inflammation biomarkers and pathways
- Erythrocyte Function and Pathophysiology
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- S100 Proteins and Annexins
- CAR-T cell therapy research
- RNA and protein synthesis mechanisms
- interferon and immune responses
- Chronic Myeloid Leukemia Treatments
Albert Einstein College of Medicine
2016-2024
Montefiore Medical Center
2019-2024
Montefiore Einstein Comprehensive Cancer Center
2024
Cancer Institute (WIA)
2022
Indian Institute of Science Bangalore
2014-2018
Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating formation of cancer fibroblasts (CAFs) are not well elucidated. An epigenomic analysis patient-derived and de-novo generated CAFs demonstrated widespread loss cytosine methylation that was overexpression various inflammatory transcripts including CXCR4. Co-culture neoplastic cells led to increased invasiveness abrogated by inhibition Metabolite tracing revealed lactate...
Mutations in the SF3B1 splicing factor are commonly seen myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), yet specific oncogenic pathways activated by mis-splicing have not been fully elucidated. Inflammatory immune shown to play roles pathogenesis of MDS, though exact mechanisms their activation mutant cases well understood.RNA-seq data from samples was analyzed functional interleukin-1 receptor-associated kinase 4 (IRAK4) isoforms were determined. Efficacy IRAK4 inhibition...
Significance This study demonstrates that underexpression of succinate dehydrogenase (SDH) subunits resulting in accumulation oncogenic is a common, adverse, epigenetic modulating feature clear cell renal carcinoma (ccRCC), during pathogenesis and progression. The sheds light on the mechanisms down-regulation SDH ccRCC deciphers consequent effects. It shows functional deficiency common (∼80% all kidney cancers), not just limited to 0.05 0.5% cancers with germline mutations.
While therapies targeting CD19 by antibodies, CAR-T cells and T cell engagers have improved the response rates in B-cell malignancies; emergence of resistant populations with low expression can lead to relapsed disease. We developed an vitro model adaptive resistance facilitated chronic exposure leukemia a CD19-immunotoxin. Single-cell (sc) RNAseq showed increase transcriptionally distinct CD19low cells. Mass cytometry demonstrated that CD22 was also decreased these ATAC-seq chromatin...
<div>AbstractPurpose:<p>Even though smoking is associated with lung cancer, the exact molecular pathways that link carcinogens inflammation and oncogenic transformation are not well elucidated. Two major in cigarette smoke, nicotine-derived nitrosamine ketone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), benzo(α)pyrene (BaP), have been tested models mimic inhaled exposure for prolonged periods of time.</p>Experimental Design:<p>Mouse were used intratracheal...
<p>Supplementary Figure S6. Downregulated phosphorylations after IRAK4 inhibitor treatment.</p>
<p>Supplementary Figure S5. Annotated MS/MS spectrum of the phosphopeptide MYH9 modified with serine 1943 phosphorylation. Red and blue lines indicate matches between observed expected fragment masses (red is b series, while y series). Fragments annotated as “-Phos” that phosphorylation fragmented out peptide leaving a diagnostic mass -96 Da.</p>
<p>Supplementary Figure S1. Uncropped Western Blots for 4C data presented in the manuscript. Also see Data Availability Statement.</p>
<p>Supplementary Figure S3. Exposure to carcinogens leads carcinogenesis in murine lungs: Representative histological examples of mouse lung observed during the study assess effect smoking carcinogens.</p>
<p>Supplementary Figure S2. Uncropped Western Blots for 6A data presented in the manuscript. Also see Data Availability Statement.</p>
<p>Supplementary Figure S4. Immunofluorescence using CD68 Cy5 on mouse lung tissues harvested after 18 months of intratracheal treatment. Magenta stain represent antibody and blue nuclear counterstain DAPI. Left, representative image for PBS administration. Right, mice administered NB (NNK BaP).</p>
<p>Supplementary Figure S6. Downregulated phosphorylations after IRAK4 inhibitor treatment.</p>
<p>Supplementary Figure S3. Exposure to carcinogens leads carcinogenesis in murine lungs: Representative histological examples of mouse lung observed during the study assess effect smoking carcinogens.</p>
<p>Supplementary Figure S1. Uncropped Western Blots for 4C data presented in the manuscript. Also see Data Availability Statement.</p>