A5072717217- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Parallel Computing and Optimization Techniques
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Embedded Systems Design Techniques
- Vitamin C and Antioxidants Research
- Acute Lymphoblastic Leukemia research
- Distributed and Parallel Computing Systems
- Cancer-related gene regulation
- CAR-T cell therapy research
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Advanced Data Storage Technologies
- Economic and Financial Impacts of Cancer
- Renal Diseases and Glomerulopathies
- Immunotherapy and Immune Responses
- Folate and B Vitamins Research
- Melanoma and MAPK Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Livestock Management and Performance Improvement
Northwestern University
1998-2024
Albert Einstein College of Medicine
2012-2021
Montefiore Medical Center
2014-2020
Research Network (United States)
2020
Mayo Clinic in Arizona
2016-2020
Cerebral Palsy Research Network
2020
AraVasc (United States)
2020
University of Portsmouth
2020
Mayo Clinic
2016-2018
Mayo Clinic in Florida
2017
Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically centered on docetaxel-based chemotherapy. We previously reported that elevated miR-375 levels were significantly associated with poor overall survival of mCRPC patients. In this study, we evaluated if induced chemo-resistance to docetaxel through regulating target genes drug resistance. first compared expression level between tissues normal using data from The Cancer Genome Atlas (TCGA). To...
Cancer cell metabolism leads to a uniquely acidic microenvironment in solid tumors, but exploiting the labile extracellular pH differences between cancer and normal tissues for clinical use has been challenging. Here we describe translation of ONM-100, nanoparticle-based fluorescent imaging agent. This is comprised an ultra-pH sensitive amphiphilic polymer, conjugated with indocyanine green, which rapidly irreversibly dissociates fluoresce tumor due mechanism nanoscale macromolecular...
Major efforts are underway to identify agents that can potentiate effects of immune checkpoint inhibition. Here, we show ascorbic acid (AA) treatment caused genomewide demethylation and enhanced expression endogenous retroviral elements in lymphoma cells. AA also increased 5-hydroxymethylcytosine (5hmC) levels CD8+ T cells their cytotoxic activity a coculture system. High-dose synergized with anti-PD1 therapy syngeneic mouse model, resulting marked inhibition tumor growth compared either...
The Ten Eleven Translocation (TET) enzymes have been found to be mutated in both diffuse large B-cell (DLBCL) and peripheral T-cell (PTCL) lymphomas resulting DNA hypermethylation. Recent studies embryonal stem cells showed that ascorbic acid (AA) is a cofactor for TET with binding site at the catalytic domain, enhances activity. We hypothesized AA could potentially enhance activity lymphoma cause demethylation, reactivate expression of tumor suppressor genes chemosensitivity. demonstrate...
Although clear cell renal carcinoma (ccRCC) has been shown to result in widespread aberrant cytosine methylation and loss of 5-hydroxymethylcytosine (5hmC), the prognostic impact therapeutic targeting this epigenetic aberrancy not fully explored. Analysis 576 primary ccRCC samples demonstrated that 5hmC was strongly associated with aggressive clinicopathologic features an independent adverse factor. Loss also predicted reduced progression-free survival after resection nonmetastatic disease....
Although the combination of nivolumab plus ipilimumab has unquestionable benefit over monotherapy in advanced melanoma, currently no summative analyses have compared with for cancers other than melanoma.To examine whether addition to standard-dose safely improves clinical outcomes patients melanoma.Electronic databases (PubMed, EBSCO Information Services, Embase, and Cochrane Library) were systematically searched studies vs alone treatment melanoma published from database inception October...
Significance This study demonstrates that underexpression of succinate dehydrogenase (SDH) subunits resulting in accumulation oncogenic is a common, adverse, epigenetic modulating feature clear cell renal carcinoma (ccRCC), during pathogenesis and progression. The sheds light on the mechanisms down-regulation SDH ccRCC deciphers consequent effects. It shows functional deficiency common (∼80% all kidney cancers), not just limited to 0.05 0.5% cancers with germline mutations.
Recently, high-level languages such as MATLAB have become popular in prototyping algorithms domains signal and image processing. Many of these applications whose subtasks diverse execution requirements, often employ distributed, heterogeneous, reconfigurable systems. These systems consist an interconnected set heterogeneous processing resources that provide a variety architectural capabilities. The objective the MATCH (MATLAB Compiler for Heterogeneous Computing Systems) compiler project at...
Even though recent studies have shown that genetic changes at enhancers can influence carcinogenesis, most methylomic focused on promoters. We used renal cell carcinoma (RCC), an incurable malignancy associated with mutations in epigenetic regulators, as a model to study genome-wide patterns of DNA methylation high resolution.Analysis cytosine status 1.3 million CpGs was determined by the HELP assay RCC and healthy microdissected tubular controls.We observed samples were characterized...
Genetic profiling of urine cell free DNA (cfDNA) has not been evaluated in advanced prostate cancer. We performed whole genome sequencing cfDNAs to identify tumor-associated copy number variations before and after initiating androgen deprivation therapy HSPC stage docetaxel chemotherapy CRPC stage. A log2 ratio-based analysis detected common genomic abnormalities cancer including AR amplification 5/10 patients. Other identified included TMPRSS2-ERG fusion, PTEN gene deletion, NOTCH1 locus...
Clear cell renal carcinoma (CCRCC) is an incurable malignancy in advanced stages and needs newer therapeutic targets. Transcriptomic analysis of CCRCCs matched microdissected tubular controls revealed overexpression NOTCH ligands receptors tumor tissues. Examination the TCGA RNA-seq data set also widespread activation pathway a large cohort CCRCC samples. Samples with were clinically distinct associated better overall survival. Parallel DNA methylation copy number demonstrated that both...
Esophageal adenocarcinoma (EAC) is one of the fastest growing malignancies in US and needs newer therapeutic diagnostic strategies. Chronic inflammation plays a role pathogenesis EAC contributes to dysplastic conversion normal esophageal epithelium Barrett's esophagus frank adenocarcinoma. Chemokines play important roles mediating recent evidence implicates these ligands their receptors development spread various tumors. We demonstrated that chemokines IL8, CXCL1 CXCL3 are significantly...