A5100552115- Prostate Cancer Treatment and Research
- Wood and Agarwood Research
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Microtubule and mitosis dynamics
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Analysis
- Cancer-related gene regulation
- PARP inhibition in cancer therapy
- Protist diversity and phylogeny
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Plant biochemistry and biosynthesis
- Biological Stains and Phytochemicals
- Microbial Metabolism and Applications
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
- Identification and Quantification in Food
- Cancer Research and Treatments
- Pediatric health and respiratory diseases
First Affiliated Hospital of Zhengzhou University
2011-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Xi'an Jiaotong University
2023-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2023-2024
Jining Medical University
2024
People's Liberation Army 411 Hospital
2022-2023
Yangzhou University
2023
Yunnan University
2022
East China Normal University
2022
Southern Medical University
2010-2021
Agarwood is the fragrant resin-infused wood derived from wounded trees of Aquilaria species. It a valuable non-timber forest product used in fragrances and as medicine. Reforestation for combination with artificial agarwood-inducing methods serves way to supply agarwood conserve wild stock. However, existing produce poor-quality at low yield. Our study evaluated novel technique producing cultivated trees, called whole-tree (Agar-Wit). Ten different inducers were comparison Agar-Wit three...
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited understanding of intricate mechanisms underlying I/R hinders development effective therapeutic interventions. Wnt signaling pathway exhibits extensive crosstalk with various other pathways, forming a network system pathways involved in injury. This review article elucidates signaling, as well complex interplay between and including Notch,...
Abstract Background Agarwood is an expensive resinous heartwood derived from Aquilaria plants that widely used in traditional medicines, incense and perfume. Only wounded trees can produce agarwood, the huge demand for agarwood products has led all spp. being endangered listed Appendix II of CITES ( http://www.cites.org ). The major components are sesquiterpenes phenylethyl chromones. Owing to a lack genomic information, molecular basis wound-induced biosynthesis formation remains unknown....
Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically centered on docetaxel-based chemotherapy. We previously reported that elevated miR-375 levels were significantly associated with poor overall survival of mCRPC patients. In this study, we evaluated if induced chemo-resistance to docetaxel through regulating target genes drug resistance. first compared expression level between tissues normal using data from The Cancer Genome Atlas (TCGA). To...
CRISPR/Cas9-mediated genome editing has the potential to delete PD-L1 both on cell surface and inside cell, thereby inhibiting tumor growth migration overcoming immunosuppression. ZG16, with its lectin structure, can reduce expression surface. However, direct comparison of two approaches in Pancreatic ductal adenocarcinoma (PDAC) cells not yet been investigated. In this study, we established Panc-1 line: one knockout another ZG16 overexpression. Both methods promoted polarization...
Dalbergia odorifera is widely used to treat cardiovascular diseases. Our research group found that volatile oil has a good anti-myocardial ischemic effect, and its main pharmacodynamic components are trans-nerolol oxides. However, the exact mechanisms underlying this effect have not yet been elucidated. This study aimed explore potential myocardial protective effects of molecular mechanisms. Molecular docking was predict visualize possible mechanism anti-apoptotic protection by...
The purpose of this study was to identify the role interferon regulatory factor 7 (IRF7) in bone metastasis prostate cancer. Herein we demonstrated lower expression IRF7 metastases Overexpression cancer cells had a marked effect on inhibiting but not tumor growth xenograft nude mice. While vitro, upregulation little malignant phenotype including proliferation, apoptosis, migration, and invasion. However, overexpressing significantly enhanced activity NK cells, which resulted cytolysis target...
Zymogen granule protein 16 (ZG16) is one of the most significantly down-regulated genes in colorectal cancer (CRC) tissues. This study aimed to further evaluate its expression changes and investigate association with molecular clinicopathological characteristics CRC. We applied quantitative RT-PCR determine difference between tumor matched normal tissues from 23 CRC patients. To validate down-regulation tissues, we performed immunohistochemistry (IHC) analysis 40 paraffin-embedded...
The immunosuppressive tumor microenvironment plays an essential role in the treatment of head and neck squamous cell carcinoma (HNSC). Compared to traditional chemoradiotherapy, immune checkpoint inhibitors (ICIs) have become increasingly important HNSC therapy. Prior studies linked efficacy ICIs PD-L1, microsatellite instability (MSI), HPV infection, mutation burden (TMB), lymphocyte infiltration patients with HNSC, but further verification is needed. Additional predictors are needed...
As widely recognized, agarwood formation in Aquilaria trees is induced by external wounding. Because usually harbors specific microbes, the function of microbes has been debated for almost a century. In this study, two wounding methods, burning-chisel-drilling method (BCD) and whole-tree agarwood-inducing (Agar-Wit), were used under non-contamination environmental microorganisms. After pyrosequencing small rRNA subunits wounds BCD Agar-Wit, no substantial variation was observed either fungal...
Rationale: Chemoresistance frequently occurs in patients with small cell lung cancer (SCLC) and leads to a dismal prognosis.However, the mechanisms underlying this process remain largely unclear. Methods:The effects of chromodomain Y-like (CDYL) on chemoresistance SCLC were determined using Western blotting, immunohistochemistry, counting kit-8 assays, flow cytometry, tumorigenicity experiments, investigated mRNA sequencing, chromatin immunoprecipitation-qPCR, electrophoretic mobility shift...
N-acetylglucosaminyltransferase V (Gnt-V) has been linked to the migration of various human cancers. Recently we have found that inhibition Gnt-V increases radiosensitivity cancer cells. However, mechanisms by which mediates and migration, especially in small cell lung (SCLC) remain unknown. In our study, two SCLC lines (H1688 H146) were used investigate whether modulated cells through epithelial-mesenchymal transition (EMT). The results showed expression correlated with N stage patients...
Dalbergia odorifera, a critically endangered tree species, produces heartwood containing vast variety of flavonoids. This heartwood, also known as Chinese rosewood, has high economic and medicinal value, but its formation takes several decades. In this study, we showed that discolored wood induced by pruning displays similar color, structure, flavonoids content to those natural suggesting wounding is an efficient method for inducing flavonoid production in D. odorifera. Transcriptome...
CRC is a heterogeneous disease due to global molecular alterations, including mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H). Immunotherapy has achieved durable responses in subset of patients with dMMR-MSI-H metastatic CRC. It been showed that Loss ZG16 highly associated colorectal cancer. However, whether modulates tumor immunity cancer unclear. In this study, we demonstrated the expression distant metastasis lymphatic invasive Besides, negatively correlated...