Xiaohong Zhao

ORCID: 0000-0001-7268-2504
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About
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Research Areas
  • Constructed Wetlands for Wastewater Treatment
  • Phosphorus and nutrient management
  • Wastewater Treatment and Nitrogen Removal
  • Prion Diseases and Protein Misfolding
  • Cellular transport and secretion
  • Natural product bioactivities and synthesis
  • MicroRNA in disease regulation
  • Wound Healing and Treatments
  • X-ray Diffraction in Crystallography
  • Estrogen and related hormone effects
  • Neurological diseases and metabolism
  • Cancer-related molecular mechanisms research
  • Crystallization and Solubility Studies
  • Mesenchymal stem cell research
  • Trace Elements in Health
  • Nutrition and Health in Aging
  • Frailty in Older Adults
  • Pancreatic function and diabetes
  • RNA Research and Splicing
  • Air Quality and Health Impacts
  • Enzyme Structure and Function
  • Microbial Fuel Cells and Bioremediation
  • Endoplasmic Reticulum Stress and Disease
  • Bioactive Compounds and Antitumor Agents
  • Cardiovascular Health and Disease Prevention

Tsinghua University
2011-2025

Chang'an University
2014-2025

Center for Life Sciences
2025

Powerchina Huadong Engineering Corporation (China)
2025

Zhejiang University
2010-2024

Southwest Hospital
2020-2024

Army Medical University
2020-2024

Zhejiang Taizhou Hospital
2023-2024

Wenzhou Medical University
2023-2024

Hangzhou Normal University
2024

Bioadhesives reduce operation time and surgical complications. However, in the presence of blood, adhesion strength is often compromised. Inspired by blood clotting activity snake venom, we report a visible light-induced blood-resistant hemostatic adhesive (HAD) containing gelatin methacryloyl reptilase, which hemocoagulase (HC) extracted from Bothrops atrox HAD leads to activation aggregation platelets efficiently transforms fibrinogen into fibrin achieve rapid hemostasis seal tissue. Blood...

10.1126/sciadv.abf9635 article EN cc-by-nc Science Advances 2021-07-14

Diabetes is a prevalent chronic disease that traditionally requires severe reliance on medication for treatment. Oral and exogenous insulin can only temporarily maintain blood glucose levels do not cure the disease. Most patients need life-long injections of insulin. In recent years, advances in islet transplantation have significantly advanced treatment diabetes, allowing to discontinue avoid complications.Long-term follow-up results from reports suggest they provide significant therapeutic...

10.3389/fimmu.2024.1391504 article EN cc-by Frontiers in Immunology 2024-06-03

A new development on treatment wetland technology for the purpose of achieving high rate nitrogen removal from strength wastewater has been made in this study. The laboratory scale alum sludge-based intermittent aeration constructed (AlS-IACW) was integrated with predenitrification, aeration, and step-feeding strategies. Results obtained 280 days operation have demonstrated extraordinary performance mean total (TN) efficiency 90% under N loading (NLR) 46.7 g m–2 d–1. This a substantial...

10.1021/es204105h article EN Environmental Science & Technology 2012-03-16

During clathrin-mediated endocytosis, clathrin-coated pits invaginate to form vesicles (CVs). Since are planar structures, whereas CVs spherical, there must be a structural rearrangement of clathrin as invagination occurs. This could occur through simple addition triskelions the edges growing with very little exchange occurring between in and free cytosol, or it large scale bound clathrin. In present study, we investigated this question by studying both vitro vivo. We found that baskets do...

10.1083/jcb.200104085 article EN The Journal of Cell Biology 2001-10-15

Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but signatures varied between different populations. Squamous cell carcinoma (SCC) is one major subtype of urgently needs to aid patient management. Here, we undertook the first comprehensive investigation on in Chinese SCC patients.MicroRNA expression was measured cancerous and noncancerous tissue pairs strictly collected from patients (stages I-III), who had not been treated with...

10.1158/1078-0432.ccr-11-0419 article EN Clinical Cancer Research 2011-09-04

Evidence for the participation of opioid neuropeptides in immunoregulatory activities, especially cellular adherence and migration, has been obtained representatives two phyla invertebrates, mollusc Mytilus edulis insect Leucophaea maderae. The injection a synthetic analog [Met]enkephalin [( D-Ala2,Met5]enkephalinamide, DAMA; 10(-6) M) had stimulatory, naloxone-reversible effect on directed migration immunocompetent hemocytes. Incubation hemolymph presence exogenous or endogenous material...

10.1073/pnas.86.2.626 article EN Proceedings of the National Academy of Sciences 1989-01-01

microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and play important roles in tumor initiation progression. Recently, we examined global miRNA profile of esophageal squamous cell carcinoma (ESCC) demonstrated that miR-92a was highly expressed tissues. In this study, found up-regulation significantly correlated with status lymph node metastasis TNM stage 107 ESCC patients. Moreover, associated poor survival patients might be used as an independent prognostic...

10.1074/jbc.m110.165654 article EN cc-by Journal of Biological Chemistry 2010-12-10

Frailty associated with aging increases the risk of falls, disability, and death. We investigated gender-associated factors for frailty.Data 3,079 geriatric subjects were retrieved from National Health Nutrition Examination Survey (NHANES) 2007-2010 database. After excluding 1,126 missing data on frailty, medical history survival, 1,953 patients analyzed. Main endpoints frailty prevalence, mortality rates causes death.Frailty prevalence was 5.4% in males, 8.8% females. Significant males...

10.7717/peerj.4326 article EN cc-by PeerJ 2018-02-28

Abstract Achieving hemostasis in penetrating and irregular wounds is challenging because the factor cannot arrive at bleeding site, substantial will wash away blood clot. Since inherently gradual nature of clot formation takes time, a physical barrier needed before formation. Herein, an ultra‐light shape memory hemostatic aerogel consisting oxidized bacterial cellulose (OBC) platelet extracellular vesicles (pVEs) reported. The OBC‐pVEs provides for site by self‐expansion, absorbing liquid...

10.1002/adhm.202304523 article EN cc-by Advanced Healthcare Materials 2024-02-12

Auxilin is a brain-specific DnaJ homolog that required for Hsc70 to dissociate clathrin from bovine brain clathrin-coated vesicles. However, also involved in uncoating vesicles formed at the plasma membrane of non-neuronal cells suggesting an auxilin may be these cells. One candidate cyclin G-associated kinase (GAK), 150-kDa protein expressed ubiquitously various tissues. GAK has C-terminal domain with high sequence similarity auxilin; like this consists three subdomains, N-terminal...

10.1074/jbc.275.2.1365 article EN cc-by Journal of Biological Chemistry 2000-01-01

Cyclin E is reported to be an important cell cycle regulator, and its dysregulation implicated in tumorigenesis including esophageal squamous carcinoma (ESCC). MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level play roles tumor initiation progression. However, regulation of cyclin by miRNAs still unclear ESCC. In present study, we found that overexpression miR-29c inhibited targeting 3′ untranslated region messenger RNA ESCC cells. Moreover, induced G1/G0 arrest...

10.1093/carcin/bgr078 article EN Carcinogenesis 2011-05-05
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