A5102745489- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Forensic and Genetic Research
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Molecular Biology Techniques and Applications
- CAR-T cell therapy research
- Age of Information Optimization
- Melanoma and MAPK Pathways
- Mitochondrial Function and Pathology
- Network Security and Intrusion Detection
- Atherosclerosis and Cardiovascular Diseases
- Polymer Surface Interaction Studies
- IoT and Edge/Fog Computing
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Adipose Tissue and Metabolism
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Telomeres, Telomerase, and Senescence
Shanghai Jiao Tong University
2014-2025
Shanghai First People's Hospital
2024-2025
Center for Life Sciences
2023-2025
Tsinghua University
2022-2025
Peking University
2025
Peking University Third Hospital
2025
Shanghai Jinyuan Senior High School
2024
University of California, Davis
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Anhui Medical University
2024
Abstract Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25% one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial fatty acid oxidation (FAO) enzymes (CPT1A, CPT2 and ACAD9) immune checkpoint CD47 is dominant in recurrent GBM patients poor prognosis. A glycolysis-to-FAO metabolic rewiring associated anti-phagocytosis radioresistant cells regrown radiation syngeneic mice. Inhibition FAO by CPT1 inhibitor etomoxir or...
In cancer, persistent antigens drive CD8+ T cell differentiation into exhausted progenitor (Texprog) and terminally (Texterm) cells. However, how the extrinsic intrinsic regulatory mechanisms cooperate during this process still remains not well understood. Here, we found that STAT3 signaling plays essential roles in promoting intratumor Texterm development by enhancing their effector functions survival, which results better tumor control. microenvironments, is predominantly activated IL-10...
Tumor cells, including cancer stem cells (CSCs) resistant to radio- and chemotherapy, must enhance metabolism meet the extra energy demands repair survive such genotoxic conditions. However, stress-induced adaptive metabolic alterations, especially in that radiotherapy, remain unresolved. In this study, we found CPT1 (Carnitine palmitoyl transferase I) CPT2 II), a pair of rate-limiting enzymes for mitochondrial fatty acid transportation, play critical role increasing oxidation (FAO) required...
Highlights•Radioresistant cancer cells reprogram metabolic flux toward glutamine anabolism•GS promotes cellular nucleotide synthesis for efficient DNA repair•High expression of GS facilitates growth under radiation stress•GS is transcriptionally regulated by STAT5SummaryRadiation resistance a critical problem in radiotherapy cancer. Radiation kills tumor mainly through causing damage. Thus, efficiency damage repair one the most important factors that limits efficacy. Glutamine...
Abstract Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, immunosuppressive factors induced radiation on tumor cells remain to identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast (BC) and RT-treated mouse syngeneic BC. Co-expression both receptors more frequently detected recurrent BC patients poor prognosis. CD47 preferentially HER2-expressing cells, blocking or reduces...
Abstract Paclitaxel is clinically used as a first-line chemotherapeutic regimen for several cancer types, including head and neck cancers. However, acquired drug resistance results in the failure of therapy, metastasis relapse. The efflux mediated by ATP-binding cassette (ABC) transporters survival signals activated forkhead box (FOX) molecules are critical development paclitaxel resistance. Whether FOX promote through remains unknown. In this study, we developed types paclitaxel-resistant...
Overcoming CD8+ T cell exhaustion is critical in cancer immunotherapy. Recently, an intratumor stem/progenitor-like (Tprog cell) population that mediates the persistence of antitumor responses has been defined, which can further develop into a terminally differentiated (Tterm subpopulation with potent cytotoxic functions. Tprog cells are main responders to immune checkpoint blockade therapies, yet how extrinsic signals via transcription factors control generation and tumors unclear. Here, we...
Abstract Background Metastasis accounts for the majority of deaths among patients with colorectal cancer (CRC). Here, regulatory role tumour‐associated macrophages (TAMs) in CRC metastasis was explored. Methods Immunohistochemical (IHC) analysis TAM biomarker CD163 conducted to evaluate infiltration CRC. Transwell assays and an ectopic liver model were established metastatic ability tumour cells. RNA sequencing (RNA‐seq) liquid chromatography‒mass spectrometry (LC‒MS) applied identify...
Although nontumor components play an essential role in colon cancer (CC) progression, the intercellular communication between CC cells and adjacent colonic epithelial (CECs) remains poorly understood. Here, we show that intact mitochondrial genome (mitochondrial DNA, mtDNA) is enriched serum extracellular vesicles (EVs) from patients positively correlated with tumor stage. Intriguingly, circular mtDNA transferred via cell-derived EVs (EV-mtDNA) enhances respiration reactive oxygen species...
Ionizing radiation (IR) is a conventional cancer therapeutic, to which cells develop radioresistance with exposure. The residual after treatment also have increased metastatic potential. mechanisms by and gain potential are still unknown. In this study acute IR exposure induced cell senescence apoptosis, but long-term exposure, exhibited radioresistance. proliferation of radioresistant was retarded, most were arrested in G0/G1 phase. simultaneously showed resistance further IR-induced...
T cell activation is accompanied by extensive changes in epigenome. However, the high-ordered chromatin organization underpinning CD8+ not fully known. Here, we show three-dimensional genome during activation, associated with gene transcription. We that T-cell-specific deletion of Trim28 mice disrupts autocrine IL-2 production and leads to impaired vitro vivo. Mechanistically, TRIM28 binds regulatory regions genes formation chromosomal loops activation. At loop anchor regions,...
Seasonal coronaviruses, similar to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), only cause symptoms in a small fraction of infected individuals. However, the host factors that determine variable responses infection remain unclear. Here, we use seasonal human OC43 (HCoV-OC43) as an asymptomatic model triggers both innate and adaptive immune mice. Interestingly, sensing pathways well cells are not essential protection against HCoV-OC43. Instead, alveolar macrophage (AMΦ)...
Radiotherapy (RT) is the major modality for control of glioblastoma multiforme (GBM), most aggressive brain tumor in adults with poor prognosis and low patient survival rate. To improve RT efficacy on GBM, mechanism causing adaptive radioresistance which leads to failure lethal progression needs be further elucidated. Here, we conducted a comparative analysis RT-treated recurrent tumors versus primary counterparts GBM patients, orthotopic xenografts untreated radioresistant cells wild type...
Periostin (POSTN) secreted by intrahepatic cholangiocarcinoma stem cells (ICSCs) serves important roles in promoting tumor progression. The present study aimed to investigate POSTN-recruited tumor-associated macrophages (TAMs) (ICC). A total of 50 cases were used the distribution ICSCs and TAMs ICC. HCCC-9810 sorted cluster differentiation (CD)44, expression POSTN CD44+ (cancer cells) CD44- (non-cancer cells), medium evaluated western blot analysis. THP-1 detect effects on recruiting vitro....
Edge intelligence is an emerging paradigm for real-time training and inference at the wireless edge, thus enabling mission-critical applications. Accordingly, base stations (BSs) edge servers (ESs) need to be densely deployed, leading huge deployment operation costs, in particular energy costs. In this article, we propose a new framework called Mobility-Enhanced inTelligence (MEET), which exploits sensing, communication, computing, self-powering capabilities of intelligent connected vehicles...
Radiation therapy elicits profound alterations in gene expression tumor cells. This study aims to determine the dynamic changes of immunity-associated genes nasopharyngeal carcinoma (NPC) cells upon radiation therapy.The was performed using NPC patient-derived xenograft tumors, cell lines, CCR4+ CD8 T sorted from peripheral blood mononuclear healthy volunteers, and TCGA-derived bulk RNA-seq or single-cell (scRNA-seq) data sets. Patient-derived tumors lines were irradiated collected for RNA...